期刊
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
卷 73, 期 -, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.jtemb.2022.127023
关键词
Curcumin; Zinc; Protective and therapeutic; Chronic diseases; Antioxidant; Inflammation
Curcumin, a polyphenolic compound isolated from turmeric rhizome, has various protective and therapeutic effects. To enhance its pharmacological activities, complexes of curcumin with metals such as zinc have been synthesized. Zinc-curcumin complexes display enhanced antioxidant, anti-inflammatory, anticancer, antimicrobial and antidiabetic properties, and also show hepatoprotective, gastroprotective, neuroprotective, cardioprotective and osteogenesis efficacy.
Curcumin, a polyphenolic compound isolated from turmeric rhizome, displays antioxidant, anti-inflammatory, anticancer, anti-microbial, antiviral, antidiabetic, neuroprotective, immune boosting and other chemo-preventive and therapeutic properties. However, the efficacy of curcumin is confined due to its aqueous insol-ubility, instability, low intestinal absorption, poor bioavailability, and systemic elimination. Therefore, to overcome these issues and enhance pharmacological activities of curcumin, a complex of curcumin with metals such as zinc have been synthesized. Curcumin acts as a ligand and forms a stable complex with zinc. In this review, the improved protective, and therapeutic activities of zinc-curcumin complexes are discussed. Zinc-curcumin conjugates have exhibited enhanced antioxidant, anti-inflammatory, anticancer, antimicrobial and antidiabetic properties. Zinc-curcumin complexes have also displayed hepatoprotective, gastroprotective, neu-roprotective, cardioprotective and osteogenesis efficacy. These protective and therapeutic efficacies of zinc-curcumin conjugates were associated with modulation of multiple molecular mechanisms including decreased inflammatory cytokines, increased antioxidant enzymes, quenched free radicals, decreased blood glucose levels, decreased insulin resistance, induced apoptosis markers, and restored function of tumor suppressor protein p53 in cancer cells. Overall, applications of zinc-curcumin complex could be a new approach against various diseases and could also be helpful in improvement of health.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据