☆ 4.3 Review

Gut-oriented disease modifying therapy for Parkinson's disease

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2023)

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Review Cell Biology

The Gut-Brain Axis: Two Ways Signaling in Parkinson's Disease

Nitu Dogra et al.

Summary: Parkinson's disease is a chronic and progressive neurological disorder involving the motor system, with its pathogenesis closely related to the gut microbiome and the gut-brain axis, which may influence the disease progression through various mechanisms. Understanding the interaction between the gut-brain axis, gut microbiota, and Parkinson's disease is crucial for the development of novel therapeutic and diagnostic approaches.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2022)

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Article Clinical Neurology

Association of Fecal and Plasma Levels of Short-Chain Fatty Acids With Gut Microbiota and Clinical Severity in Patients With Parkinson Disease

Szu-Ju Chen et al.

Summary: Patients with PD had lower fecal but higher plasma concentrations of SCFAs compared to controls, with specific gut microbiota changes and clinical severity of PD.

NEUROLOGY (2022)

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Article Clinical Neurology

The faecal metabolome and mycobiome in Parkinson's disease

Eduardo De Pablo-Fernandez et al.

Summary: This study evaluated the fecal metabolome and mycobiome in Parkinson's disease (PD) patients and found differences in VOC abundance and fungal composition between PD and control groups, suggesting a potential role of fungal dysbiosis in PD pathogenesis.

PARKINSONISM & RELATED DISORDERS (2022)

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Article Clinical Neurology

Gut microbiome in Parkinson's disease: New insights from meta-analysis

Tzi Shin Toh et al.

Summary: The main factors influencing gut microbiome composition in Parkinson's disease patients include study and geographical differences. The microbiome composition was more similar within the same study compared to different studies. Differences in microbiome composition were significant between Caucasian and non-Caucasian populations, and also between PD patients and controls.

PARKINSONISM & RELATED DISORDERS (2022)

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Article Food Science & Technology

Polymannuronic acid prebiotic plus Lacticaseibacillus rhamnosus GG probiotic as a novel synbiotic promoted their separate neuroprotection Parkinson's disease

Xin Liu et al.

Summary: This study discovered that the combination of polymannuronic acid (PM) and Lacticaseibacillus rhamnosus GG (LGG) provided neuroprotection in a chronic Parkinson's disease (PD) mice model. PM exerted neuroprotection through a short chain fatty acids (SCFAs)-mediated anti-inflammation and anti-apoptosis mechanism, while LGG may improve the expression of striatal glial cell-derived neurotrophic factor (GDNF) and increase the abundance of Clostridiales bacteria. The combination of PM and LGG showed better neuroprotective effects than using PM or LGG alone.

FOOD RESEARCH INTERNATIONAL (2022)

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Article Neurosciences

Alteration of Gut Microbial Metabolites in the Systemic Circulation of Patients with Parkinson's Disease

Szu-Ju Chen et al.

Summary: This study found that PD patients had significantly higher levels of HA, IPA, DCA, and GDCA in plasma, which were positively associated with PD status. Concentrations of these metabolites were not correlated with PD severity, but were associated with the relative abundance of pro-inflammatory gut bacteria.

JOURNAL OF PARKINSONS DISEASE (2022)

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Article Neurosciences

Probiotics synergized with conventional regimen in managing Parkinson's disease

Hairong Sun et al.

Summary: The study found that co-administration of the probiotic Probio-M8 can improve sleep quality, alleviate anxiety, and gastrointestinal symptoms in patients with Parkinson's disease. It also has an impact on the host's gut microbiome, gut microbial metabolic potential, and serum metabolites.

NPJ PARKINSONS DISEASE (2022)

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Review Clinical Neurology

The microbiome-gut-brain axis in Parkinson disease - from basic research to the clinic

Ai Huey Tan et al.

Summary: The close bidirectional link between the brain and the gut in Parkinson disease has led to a paradigm shift in neurology. Gut-related factors play significant roles in the development, progression, and treatment responses of Parkinson disease, and could potentially be targeted for therapeutics. The gut microbiome, in particular, has been highlighted as an important factor. Future directions for the field include further understanding of the gut-brain axis and addressing current knowledge gaps and challenges.

NATURE REVIEWS NEUROLOGY (2022)

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Article Immunology

Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson's disease via gut microbiota-GLP-1 pathway

Jing Sun et al.

Summary: The study suggests that the probiotic Clostridium butyricum (Cb) has neuroprotective effects on Parkinson's disease (PD) by improving abnormal gut microbiota-gut-brain axis. This intervention could potentially reverse motor deficits, dopaminergic neuron loss, synaptic dysfunction, and microglia activation in PD, providing a new insight into treating PD through gut microbiota modulation.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Review Immunology

Neurogenic and anti-inflammatory effects of probiotics in Parkinson's disease: A systematic review of preclinical and clinical evidence

Valentina Leta et al.

Summary: The gut-brain axis plays a potential role in Parkinson's disease (PD), and probiotics have shown beneficial effects on energy metabolism, inflammation, neurodegeneration, and motor/non-motor function in both preclinical and clinical studies. However, further robust research is needed to confirm these outcomes and bridge the gap between preclinical and clinical findings.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Neurosciences

Does Gut Microbiota Influence the Course of Parkinson's Disease? A 3-Year Prospective Exploratory Study in de novo Patients

Roberto Cilia et al.

Summary: The study found an association between abnormal distribution of specific bacterial taxa in de novo PD patients and the progression of motor and non-motor features over a 3-year period. This supports the design of a larger observational studyaiming to define microbiota-specific subgroups suitable for therapeutic targeting.

JOURNAL OF PARKINSONS DISEASE (2021)

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Article Neurosciences

Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in Parkinson's disease

Velma T. E. Aho et al.

Summary: This study found that intestinal inflammatory responses and reductions in fecal SCFAs occur in Parkinson's disease (PD), are related to the microbiota and to disease onset, and are not reflected in plasma inflammatory profiles. Some of these relationships are distinct in PD and are sex-dependent. This study revealed potential alterations in microbiota-host interactions and links between earlier PD onset and intestinal inflammatory responses and reduced SCFA levels.

MOLECULAR NEURODEGENERATION (2021)

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Article Cell Biology

Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson's disease

Dorines Rosario et al.

Summary: Parkinson's disease (PD) is a common progressive neurological disorder that affects motor functions, with gastrointestinal (GI) dysfunction being an early nonmotor symptom. This study used metagenomics and serum metabolomics to investigate the gut microbiome of PD patients. The findings suggest that gut microbial composition and metabolism may play a role in PD pathophysiology.

CELL REPORTS (2021)

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Review Geriatrics & Gerontology

The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis

Ting Shen et al.

Summary: This meta-analysis revealed lower abundance levels of Prevotellaceae, Faecalibacterium, and Lachnospiraceae, and higher abundance levels of Bifidobacteriaceae, Ruminococcaceae, Verrucomicrobiaceae, and Christensenellaceae in patients with PD compared to HCs.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Article Neurosciences

The Gut Mycobiome in Parkinson's Disease

Mihai S. Cirstea et al.

Summary: Using fungal-specific ITS-2 amplicon sequencing, researchers found very low fungal load among Parkinson's disease (PD) patients, with identified genera mainly from dietary or environmental sources. There were no differences in fungal abundance between patients and controls, and no fungal species were associated with motor, cognitive, or gastrointestinal features among patients.

JOURNAL OF PARKINSONS DISEASE (2021)

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Article Neurosciences

Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation

Stefano Romano et al.

Summary: Recent studies have shown significant alterations in the gut microbiome of Parkinson's disease patients compared to healthy individuals, which may result in a pro-inflammatory status and impact the symptoms and pathophysiology of the disease.

NPJ PARKINSONS DISEASE (2021)

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Article Microbiology

Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis

Zhe Zhao et al.

Summary: This study demonstrates that FMT treatment can correct gut microbiota dysbiosis and ameliorate the rotenone-induced PD mouse model, possibly playing a significant role in suppressing inflammation via the LPS-TLR4 signaling pathway in both the gut and the brain. Furthermore, the study proves the involvement of rotenone-induced microbiota dysbiosis in the genesis of PD through the microbiota-gut-brain axis.

MICROBIOME (2021)

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Article Biotechnology & Applied Microbiology

Evaluation of fecal microbiota transplantation in Parkinson's disease patients with constipation

Xiao-yi Kuai et al.

Summary: The study showed that fecal microbiota transplantation (FMT) is effective in improving gastrointestinal dysfunction in Parkinson's disease patients, significantly reducing both motor and non-motor symptoms, regulating the gut microbiota structure, restoring intestinal bacterial overgrowth, and improving constipation symptoms.

MICROBIAL CELL FACTORIES (2021)

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Article Clinical Neurology

Fecal microbiota transplant as a potential treatment for Parkinson's disease-A case series

Arik Segal et al.

Summary: The study found that fecal microbiota transplant may be safe and effective in improving constipation, motor, and non-motor symptoms in Parkinson's disease patients. However, further research is needed to confirm these findings and assess long-term efficacy and safety, including through large scale randomized controlled trials.

CLINICAL NEUROLOGY AND NEUROSURGERY (2021)

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Article Neurosciences

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

Collin Challis et al.

NATURE NEUROSCIENCE (2020)

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Article Neurosciences

The Novel Dual GLP-1/GIP Receptor Agonist DA-CH5 Is Superior to Single GLP-1 Receptor Agonists in the MPTP Model of Parkinson?s Disease

Lingyu Zhang et al.

JOURNAL OF PARKINSONS DISEASE (2020)

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Article Biology

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

Timothy R. Sampson et al.

ELIFE (2020)

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Article Clinical Neurology

Gut Microbiota Altered in Mild Cognitive Impairment Compared With Normal Cognition in Sporadic Parkinson's Disease

Tengzhu Ren et al.

FRONTIERS IN NEUROLOGY (2020)

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Article Microbiology

Fecal microbiota transplantation to maintain remission in Crohn's disease: a pilot randomized controlled study

Harry Sokol et al.

MICROBIOME (2020)

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Article Multidisciplinary Sciences

Developing a new class of engineered live bacterial therapeutics to treat human diseases

Mark R. Charbonneau et al.

NATURE COMMUNICATIONS (2020)

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Article Biotechnology & Applied Microbiology

Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease

Xin Fang et al.

AMB EXPRESS (2020)

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Review Gastroenterology & Hepatology

Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility

Nick J. Spencer et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Immunology

Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson's disease

Jian-Fu Liao et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

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Article Biochemistry & Molecular Biology

Personalized Mapping of Drug Metabolism by the Human Gut Microbiome

Bahar Javdan et al.

CELL (2020)

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Article Neurosciences

Characterizing dysbiosis of gut microbiome in PD: evidence for overabundance of opportunistic pathogens

Zachary D. Wallen et al.

NPJ PARKINSONS DISEASE (2020)

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Article Clinical Neurology

Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study

Jacob Horsager et al.

BRAIN (2020)

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Article Clinical Neurology

Gut metagenomics-derived genes as potential biomarkers of Parkinson's disease

Yiwei Qian et al.

BRAIN (2020)

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Article Clinical Neurology

Meta-Analysisof Gut Dysbiosis in Parkinson's Disease

Hiroshi Nishiwaki et al.

MOVEMENT DISORDERS (2020)

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Review Biochemistry & Molecular Biology

Live biotherapeutic products: the importance of a defined regulatory framework

Magali Cordaillat-Simmons et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

Protective effects of Lactobacillus fermentum U-21 against paraquat-induced oxidative stress in Caenorhabditis elegans and mouse models

Maria Marsova et al.

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2020)

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Article Medicine, General & Internal

Fecal microbiota transplantation therapy for Parkinson's disease A preliminary study

Liu-Jun Xue et al.

MEDICINE (2020)

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Letter Clinical Neurology

The Gut Metabolite Trimethylamine N-Oxide Is Associated With Parkinson's Disease Severity and Progression

Szu-Ju Chen et al.

MOVEMENT DISORDERS (2020)

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Article Gastroenterology & Hepatology

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Kelly S. Swanson et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Multidisciplinary Sciences

Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson's disease: A randomised controlled trial

Azliza Ibrahim et al.

PLOS ONE (2020)

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Article Nutrition & Dietetics

Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

Omid Reza Tamtaji et al.

CLINICAL NUTRITION (2019)

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Separating host and microbiome contributions to drug pharmacokinetics and toxicity

Michael Zimmermann et al.

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Long-Term Safety and Efficacy of Fecal Microbiota Transplant in Active Ulcerative Colitis

Xiao Ding et al.

DRUG SAFETY (2019)

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Review Gastroenterology & Hepatology

The role of short-chain fatty acids in microbiota-gut-brain communication

Boushra Dalile et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Immunology

Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson's disease

Chin-Hsien Lin et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Biochemistry & Molecular Biology

Probiotics mixture increases butyrate, and subsequently rescues the nigral dopaminergic neurons from MPTP and rotenone-induced neurotoxicity

Sunil Srivastav et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2019)

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Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease

Sangjune Kim et al.

NEURON (2019)

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Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism

Vayu Maini Rekdal et al.

SCIENCE (2019)

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Potential of Prebiotic Butyrogenic Fibers in Parkinson's Disease

Thaisa M. Cantu-Jungles et al.

FRONTIERS IN NEUROLOGY (2019)

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In vitro Characterization of Gut Microbiota-Derived Bacterial Strains With Neuroprotective Properties

Suaad Ahmed et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Gastroenterology & Hepatology

Role of TLR4 in the gut-brain axis in Parkinson's disease: a translational study from men to mice

Paula Perez-Pardo et al.

GUT (2019)

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Review Biotechnology & Applied Microbiology

Engineering Microbial Living Therapeutics: The Synthetic Biology Toolbox

Danielle B. Pedrolli et al.

TRENDS IN BIOTECHNOLOGY (2019)

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Article Multidisciplinary Sciences

Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease

Sebastiaan P. van Kessel et al.

NATURE COMMUNICATIONS (2019)

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Effect of Parkinson's disease and related medications on the composition of the fecal bacterial microbiota

Severin Weis et al.

NPJ PARKINSONS DISEASE (2019)

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Review Gastroenterology & Hepatology

Fecal Microbiota Transplantation: An Update on Clinical Practice

Kyeong Ok Kim et al.

CLINICAL ENDOSCOPY (2019)

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Article Immunology

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLRLI/TNF-α signaling pathway

Meng-Fei Sun et al.

BRAIN BEHAVIOR AND IMMUNITY (2018)

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Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

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Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

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Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation

Kristina N-M Daeffler et al.

MOLECULAR SYSTEMS BIOLOGY (2017)

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Article Clinical Neurology

Parkinson's Disease and Parkinson's Disease Medications Have Distinct Signatures of the Gut Microbiome

Erin M. Hill-Burns et al.

MOVEMENT DISORDERS (2017)

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Editorial Material Gastroenterology & Hepatology

Brain-gut-microbiota axis-mood, metabolism and behaviour

Timothy G. Dinan et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

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Review Clinical Neurology

Gut microbiota: Implications in Parkinson's disease

Arun Parashar et al.

PARKINSONISM & RELATED DISORDERS (2017)

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Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naive Parkinson's disease patients

J. R. Bedarf et al.

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Constipation preceding Parkinson's disease: a systematic review and meta-analysis

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JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2016)

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Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

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Andreas J. Baumler et al.

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Probiotics and prebiotic fiber for constipation associated with Parkinson disease: An RCT

Michela Barichella et al.

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Insulin resistance and Parkinson's disease: A new target for disease modification?

D. Athauda et al.

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Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

Mar Gacias et al.

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Nonmotor gastrointestinal disorders in older patients with Parkinson's disease: is there hope?

Doina Georgescu et al.

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Fecal Microbiota Transplantation for Clostridium difficile Infection A Systematic Review

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Gut Microbiota: The Link to Your Second Brain

Vanessa Ridaura et al.

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Daniela Berg et al.

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Gut Microbes and the Brain: Paradigm Shift in Neuroscience

Emeran A. Mayer et al.

JOURNAL OF NEUROSCIENCE (2014)

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Health-related quality of life in early Parkinson's disease: The impact of nonmotor symptoms

Gordon W. Duncan et al.

MOVEMENT DISORDERS (2014)

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Article Gastroenterology & Hepatology

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

Colin Hill et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2014)

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Article Clinical Neurology

Small intestinal bacterial overgrowth in Parkinson's disease

Ai Huey Tan et al.

PARKINSONISM & RELATED DISORDERS (2014)

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Review Clinical Neurology

Parkinson's disease, insulin resistance and novel agents of neuroprotection

Iciar Aviles-Olmos et al.

BRAIN (2013)

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Article Pharmacology & Pharmacy

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Anna R. Carta

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Review Clinical Neurology

100 years of Lewy pathology

Michel Goedert et al.

NATURE REVIEWS NEUROLOGY (2013)

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Article Multidisciplinary Sciences

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

Changyoun Kim et al.

NATURE COMMUNICATIONS (2013)

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Article Multidisciplinary Sciences

Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

Kelvin C. Luk et al.

SCIENCE (2012)

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Article Multidisciplinary Sciences

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

Christopher B. Forsyth et al.

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Article Clinical Neurology

Clinical Progression in Parkinson Disease and the Neurobiology of Axons

Hsiao-Chun Cheng et al.

ANNALS OF NEUROLOGY (2010)

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Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

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Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

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