期刊
CARBOHYDRATE POLYMERS
卷 115, 期 -, 页码 139-145出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.08.085
关键词
Pectin; Pectin derivative; Biopolymers; Antitumor property; Caco-2 cells; Vero cells
资金
- CNPq
- CNPq [Proc. 400702/2012-6, 308337/2013-1, Proc. 851/09]
New pectin derivative (Pec-MA) was obtained in specific reaction conditions. The presence of maleoyl groups in Pec-MA structure was confirmed by H-1 NMR and FTIR spectroscopy. The substitution degree of Pec-MA (DS = 24%) was determined by H-1 NMR. The properties of Pec-MA were investigated through WAXS, TGA/DTG, SEM and zeta potential techniques. The Pec-MA presented amorphous characteristics and higher-thermal stability compared to raw pectin (Pec). In addition, considerable morphological differences between Pec-MA and Pec were observed by SEM. The cytotoxic effect on the Caco-2 cells showed that the Pec-MA significantly inhibited the growth of colon cancer cells whereas the Pec-MA does not show any cytotoxic effect on the VERO healthy cells. This result opens new perspectives for the manufacture of biomaterials based on Pec with anti-tumor properties. (C) 2014 Elsevier Ltd. All rights reserved.
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