期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 144, 期 44, 页码 20196-20200出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.2c08694
关键词
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资金
- National Natural Science Foundation of China
- PKU-Baidu Fund
- [21925101]
- [21572008]
- [2019BD015]
We have achieved the first total synthesis of (-)-principinol C, which is a natural product with an intriguing and complex 5/7/6/5 tetracyclic skeleton and eight contiguous stereocenters. The key step in assembling the 5/7/6/5 tetracyclic skeleton was the intramolecular Pauson-Khand reaction. This synthetic route represents the first application of intramolecular Pauson-Khand reaction of enyne to construct the 7,5-bicyclic ring system in natural product synthesis.
We have achieved the first total synthesis of (-)-principinol C, which possesses an intriguing and complex 5/7/6/5 tetracyclic skeleton with eight contiguous stereocenters. The 5/7/6/5 tetracyclic skeleton of principinol C was assembled using an intramolecular Pauson-Khand reaction as the key step. This synthetic route represents the first application of the intramolecular Pauson-Khand reaction of enyne to construct the 7,5-bicyclic ring system in natural product synthesis.
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