期刊
JOURNAL OF SUPERCRITICAL FLUIDS
卷 188, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.supflu.2022.105678
关键词
Calcium carbonate; Supercritical carbon dioxide; Microfluidics; Polymer; Polydimethyl siloxane; Vaterite
资金
- Region Pays de Loire (France)
By utilizing a continuous microfluidic method, monodisperse porous vaterite microparticles can be produced effectively. The study revealed that the size and dispersity of the CaCO3 particles are not affected by pressure but can be decreased by increasing flow rate or adding polymers.
Vaterite, a polymorphic form of precipitated calcium carbonate, is an interesting material for various applications such as formulation of drug delivery systems due to its nanoporous structure. One of the carbonation processes to obtain nanostructured microspheres of vaterite consists in mixing an aqueous calcium phase with a supercritical CO2 phase, resulting in a heterogeneous dispersion. In this study, a continuous microfluidic method has been evaluated to produce monodisperse porous vaterite microparticles. A high-pressure microfluidic set-up has been developed, revealing that the dimensions and the dispersity of the CaCO3 particles are not affected by pressure but can be decreased by increasing the flow rate of the scCO(2) and aqueous phases or addition of polymers in the aqueous phase. These observations were shown not to be related to the degree of dispersion of each phase within the microfluidic channel but to the interaction of the polymer with the CaCO3 particles and to the depressurization step at the end of the channel.
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