期刊
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 153, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2022.103679
关键词
Recurrent pregnancy loss; ANXA5; M2; ANXA5 haplotype
资金
- Shanghai Committee of Science and Technology Committee [17411967800]
This review summarizes the research progress on the correlation between SNPs in ANXA5 and RPL, revealing that certain SNPs in the promoter region of ANXA5 may be associated with the occurrence of RPL.
The incidence of recurrent pregnancy loss (RPL) in fertile women ranges from 1% to 5%, of which about 50% of them are due to unknown causes. The possible pathogenesis of RPL is an urgent problem to be solved in the clinical. Mutations or polymorphisms of certain genes in the coagulation mechanism are associated with sus-ceptibility to thrombotic diseases and are one of the main reasons for the occurrence of RPL. Among them, the ANXA5 gene was newly studied and some single nucleotide polymorphisms (SNPs) in the promoter region of ANXA5 have been reported to be associated with RPL in multiple races. In this review, we summarized the research progress on the correlation between the SNPs in ANXA5 and RPL, hoping to provide some valuable guidance for the future studies.
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