期刊
JOURNAL OF PROTEOME RESEARCH
卷 21, 期 10, 页码 2356-2366出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jproteome.2c00219
关键词
plasma proteomics; BK virus; S100A8; S100A9; kidney transplantation; allograft function
资金
- Beijing Natural Science Foundation [5202009]
- Beijing Municipal Admin-istration of Hospitals? [QML20210105]
BK virus (BKV) is a common pathogen in post-transplant infections, particularly in kidney transplantation. This study identifies S100A8/A9 as a potential host biomarker for evaluating BKV-associated allograft function impairment in kidney transplantation.
BK virus (BKV) is one of the most common pathogens in post-transplantation infections. For kidney trans-plantation, BKV infection results in the impairment of allograft function and thus increases the risk of allograft loss. However, clinical evaluation of the prognosis of BKV-associated allograft impairment is difficult. In the present study, differential plasma proteins were screened using proteomic methods from ten patients with a transition from BKV-negative to BKV activation. We identified 12 differentially expressed proteins, and S100A8 and S100A9 were the top two upregulated proteins. Data from a cross-sectional study with 66 BKV-negative and 66 BKV-positive recipients of renal transplantation indicated that plasma S100A8/ A9 was upregulated in BKV-infected recipients. Plasma S100A8/ A9 positively correlated with the 1 month creatinine increase (rho = 0.499, P = 0.021) and negatively correlated with the 1 month estimated glomerular filtration rate change (rho = -0.618, P = 0.003) in recipients with BK viremia. Using least absolute shrinkage and selection operator regression models, we found that S100A8/A9 was an independent risk factor for the decrease in allograft function after BKV infection. In conclusion, S100A8/A9 is a potential host biomarker for the clinical evaluation of BKV-associated allograft function impairment in kidney transplantation.
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