期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1113/JP282298
关键词
-
资金
- National Institute of Aging R01 [AG048262]
Ageing is associated with reductions in skeletal muscle size and function, especially in fibres expressing fast myosin heavy chain isoforms. Lifelong aerobic exercise training is insufficient to prevent decrements in fast fibre contractile function. Further research is needed to investigate the effectiveness of other strategies, such as resistance training, to preserve fast fibre size and function with ageing. Integrating single fibre contractile mechanics with other important parameters is necessary to fully understand the ageing skeletal muscle phenotype.
Ageing is accompanied by decrements in the size and function of skeletal muscle that compromise independence and quality of life in older adults. Developing therapeutic strategies to ameliorate these changes is critical but requires an in-depth mechanistic understanding of the underlying physiology. Over the past 25 years, studies on the contractile mechanics of isolated human muscle fibres have been instrumental in facilitating our understanding of the cellular mechanisms contributing to age-related skeletal muscle dysfunction. The purpose of this review is to characterize the changes that occur in single muscle fibre size and contractile function with ageing and identify key areas for future research. Surprisingly, most studies observe that the size and contractile function of fibres expressing slow myosin heavy chain (MHC) I are well-preserved with ageing. In contrast, there are profound age-related decrements in the size and contractile function of the fibres expressing the MHC II isoforms. Notably, lifelong aerobic exercise training is unable to prevent most of the decrements in fast fibre contractile function, which have been implicated as a primary mechanism for the age-related loss in whole-muscle power output. These findings reveal a critical need to investigate the effectiveness of other nutritional, pharmaceutical or exercise strategies, such as lifelong resistance training, to preserve fast fibre size and function with ageing. Moreover, integrating single fibre contractile mechanics with the molecular profile and other parameters important to contractile function (e.g. phosphorylation of regulatory proteins, innervation status, mitochondria' function, fibre economy) is necessary to comprehensively understand the ageing skeletal muscle phenotype.
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