Neuronal activity patterns in microcircuits of the cerebellar cortical C3 zone during reaching

The cerebellum is the largest sensorimotor structure in the brain. A fundamental organizational feature of its cortex is its division into a series of rostrocaudally elongated zones. These are defined by their inputs from specific parts of the inferior olive and Purkinje cell output to specific cerebellar and vestibular nuclei. However, little is known about how patterns of neuronal activity in zones, and their microcircuit subdivisions, microzones, are related to behaviour in awake animals. In the present study, we investigated the organization of microzones within the C3 zone and their activity during a skilled forelimb reaching task in cats. Neurons in different microzones of the C3 zone, functionally determined by receptive field characteristics, differed in their patterns of activity during movement. Groups of Purkinje cells belonging to different receptive field classes, and therefore belonging to different microzones, were found to collectively encode different aspects of the reach controlled by the C3 zone. Our results support the hypothesis that the cerebellar C3 zone is organized and operates within a microzonal frame of reference, with a specific relationship between the sensory input to each microzone and its motor output.

Automated summary

In this study, the organization and activity of microzones within the C3 zone during a skilled forelimb reaching task in cats were investigated. The results showed that neurons in different microzones exhibited different patterns of activity during movement, and groups of Purkinje cells belonging to different microzones collectively encoded different aspects of the reach controlled by the C3 zone. These findings suggest that the cerebellar C3 zone operates within a microzonal frame of reference.