期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 44, 期 5, 页码 1055-1060出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0300060516655243
关键词
Liquid culture; solid culture; mycobacteria; tuberculosis; BACTEC MGIT 960; Lowenstein-Jenson
Objective A retrospective study comparing the diagnostic performance of the BACTEC MGIT 960 system (M960 system; BD Worldwide, Franklin Lakes, NJ, USA) with Lowenstein-Jensen (L-J) culture to detect mycobacteria in sputum specimens from patients with suspected pulmonary tuberculosis (TB). Methods Sputum samples were analysed for the presence of acid-fast bacilli (AFB). Samples were inoculated into the M960 system and L-J culture. Positive cultures were examined for the presence of AFB. Results The M960 method detected significantly more positive samples than L-J culture (818/1676 [48.8%] vs 692/1676 [41.3%]). Using L-J culture as reference, the sensitivity, specificity, positive predictive and negative predictive values of the M960 system were 91.0%, 76.1%, 77.0% and 92.2%, respectively. The time-to-detection of mycobacteria was 11.785.16 days for M960 and 24.17 +/- 8.73 days for L-J. Conclusions The M960 system had better diagnostic capability than L-J culture. Clinical value may be maximized by combining results from both methods.
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