An H2S-Regulated Artificial Nanochannel Fabricated by a Supramolecular Coordination Strategy

Hydrogen sulfide (H2S), as the third gasotransmitter, has an important impact on physiological and pathological activities. Herein, we fabricated an artificial nanochannel with a conductance value of 2.01 nS via a supramolecular coordination strategy. Benefiting from the unique H2S-mediated covalent reaction, the nanochannel biosensor could change from ON to OFF states with the addition of H2S. Furthermore, this nanochannel directed the ion transport, showing a high rectification ratio as well as gating ratio. Subsequently, theoretical simulations were conducted to help to reveal the possible mechanism of the functionalized nanochannel. This study can provide insights for better understanding the process of H2S-regulated biological channels and fabricating gas gated nanofluids.

Automated summary

In this study, an artificial nanochannel with a conductance value of 2.01 nS was successfully fabricated using a supramolecular coordination strategy. Utilizing the unique H2S-mediated covalent reaction, the nanochannel biosensor was able to switch from ON to OFF states upon the addition of H2S. Furthermore, the nanochannel exhibited high rectification ratio and gating ratio, directing ion transport. Theoretical simulations were conducted to provide insights into the possible mechanism of the functionalized nanochannel.