Enhanced photo-hypoxia-activated combination therapy traced by AIE photosensitizer and targeted by hyaluronic acid: Disulphide bond interference of detoxification barrier

Review Oncology

Novel molecules as the emerging trends in cancer treatment: an update

Priyanka Sekar et al.

Summary: This review presents various bioactive compounds from plants, marine organisms, and microorganisms with potential anticancer effects, which specifically target cancer cells while leaving normal cells unharmed.

MEDICAL ONCOLOGY (2022)

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Article Engineering, Biomedical

A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors

Jianquan Guo et al.

Summary: Nanoparticle-based chemophotothermal therapy is a promising treatment for multidrug resistant tumors. In this study, a drug nanococktail called DIR825@histone was developed for interventional nucleus-targeted CPT. It showed efficient tumor penetration, good photothermal performance, and thermal-triggered drug release. This strategy holds great promise for treating multidrug resistant tumors and can reduce skin injury by promoting the sufficient delivery of laser energy inside the tumor.

BIOACTIVE MATERIALS (2022)

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Review Chemistry, Medicinal

Chemical molecular-based approach to overcome multidrug resistance in cancer by targeting P-glycoprotein (P-gp)

Hang Zhang et al.

Summary: This review highlights the recent achievements in drug design and mechanism studies of newly synthetic P-gp inhibitors in the past 5 years, which will help overcome multidrug resistance in cancer chemotherapy.

MEDICINAL RESEARCH REVIEWS (2021)

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Article Engineering, Biomedical

NO-releasing polypeptide nanocomposites reverse cancer multidrug resistance via triple therapies

Yue Ding et al.

Summary: A NIR/pH dual-sensitive charge-reversal polypeptide nanocomposite was developed for co-delivering a nitric oxide donor and doxorubicin, providing an effective strategy for overcoming multidrug resistance.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Construction of Hyaluronic Acid-Covered Hierarchically Porous MIL-nanoMOF for Loading and Controlled Release of Doxorubicin

Yi-Ran Yao et al.

Summary: The porous nano-sized metal-organic framework, with proper surface modification, enhances drug loading capability and introduces biocompatibility, biodegradability, and targeting functions in nano-drug delivery systems. The obtained nanoMOF nanoparticle is stable in physiological fluids and can effectively load chemotherapeutic drugs for controlled release in tumor tissues.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

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Article Oncology

Antitumor effects of curcumin in pediatric rhabdomyosarcoma in combination with chemotherapy and phototherapy in vitro

Christine Sorg et al.

Summary: The study found that curcumin effectively inhibited the proliferation and migration of pediatric RMS cells in vitro, increased cell apoptosis, and enhanced the efficacy of drug therapy.

INTERNATIONAL JOURNAL OF ONCOLOGY (2021)

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Article Nanoscience & Nanotechnology

Optimized Combination of Photodynamic Therapy and Chemotherapy Using Gelatin Nanoparticles Containing Tirapazamine and Pheophorbide a

Donghyun Lee et al.

Summary: This study developed nanoparticles containing Pba and TPZ for combination therapy, successfully suppressing tumor growth in vivo through the synergetic effects and efficient drug delivery. The results suggest that in vitro screening based on CI values, mechanism studies, and real-time in vivo imaging are promising strategies for developing optimized combination therapy nanoparticles.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Medicine, Research & Experimental

Overcoming multidrug resistance by intracellular drug release and inhibiting p-glycoprotein efflux in breast cancer

Jing Mao et al.

Summary: The KSV micelles can enhance cellular uptake and anticancer effect of the drug, while reducing the toxicity of doxorubicin.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Oncology

An aptamer-based drug delivery agent (CD133-apt-Dox) selectively and effectively kills liver cancer stem-like cells

Gang Zhou et al.

Summary: Targeting liver cancer stem-like cells using a specific aptamer against CD133 loaded with an anticancer drug showed significant therapeutic potential in treating liver cancer, demonstrating effective suppression of tumor growth in both in vitro and in vivo studies.

CANCER LETTERS (2021)

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Article Engineering, Environmental

Nanoreactor of butterfly effect inciting a triple interlocked combination of starvation/chemo/metal ion therapy by remodeling tumor microenvironment

Zining Hao et al.

Summary: This study designed a biodegradable nanoreactor with an interlocking butterfly effect to enhance therapeutic effects by reconstructing the tumor microenvironment. The nanoreactor can trigger a triplet chain reaction in tumor cells, achieving accurate and effective tumor cell ablation.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Dual-targeted 5-aminolevulinic acid derivatives with glutathione depletion function for enhanced photodynamic therapy

Ke Li et al.

Summary: The study introduces three multifunctional ALA derivates with dual-targeting and GSH depletion characteristics to enhance the therapeutic effect of ALA-based PDT. In vitro experiments demonstrate that these compounds increase tumor cell sensitivity to ROS and enhance phototoxicity. Compound 2 shows higher in vivo efficiency in PpIX production compared to ALA-OMe, suggesting the potential of using dual-targeting and GSH depletion strategy to improve tumor-specificity and anti-tumor efficiency of ALA-based PDT.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

A nano vector with photothermally enhanced drug release and retention to overcome cancer multidrug resistance

Chendong Ji et al.

Summary: Development of a Cu2-xSe-based photothermal vector for delivering triphenylphosphine-modified doxorubicin to mitochondria shows promising results in overcoming cancer multidrug resistance. The photothermal effect of the vector enhances drug release and cellular retention, leading to effective mitochondria targeting and powerful therapeutic ability against MDR tumors.

NANO TODAY (2021)

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Article Engineering, Biomedical

Tumor Microenvironment Triggered Cascade-Activation Nanoplatform for Synergistic and Precise Treatment of Hepatocellular Carcinoma

Fuli Xin et al.

Summary: The study utilizes the A-NPLap/TPZ nanoplatform as a novel approach for the synergistic therapy of HCC, inducing tumor cell apoptosis and inhibiting tumor growth by releasing beta-Lap and TPZ through targeting effect.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy

Xiaotong Cheng et al.

Summary: Overexpression of glutathione in cancer cells leads to resistance to anticancer therapies, making GSH depletion a potential target for cancer treatments. By combining with mainstream cancer therapies, GSH-depleting agents can enhance cancer cells responses to cell death stimuli.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Cancer-Cell-Activated in situ Synthesis of Mitochondria-Targeting AIE Photosensitizer for Precise Photodynamic Therapy

Yuanbo Wang et al.

Summary: This study presents a cancer-cell-activated photosensitizer synthesis strategy to selectively synthesize efficient PS with mitochondria-targeting capability for potent cancer-cell-specific ablation under light irradiation, ensuring high specificity and safety for post-treatment.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Ferrocene-containing polymersome nanoreactors for synergistically amplified tumor-specific chemodynamic therapy

Yuheng Wang et al.

Summary: By loading GOD and TPZ in responsive polymersome nanoreactors, tumor acidic microenvironment can trigger the release of TPZ prodrugs, leading to the conversion of oxygen and glucose into H2O2 under the catalysis of ferrocene and subsequent generation of (OH)• radicals. This synergistic effect efficiently kills tumor cells and suppresses tumor growth, demonstrating the potential of ferrocene-containing responsive polymersome nanoreactors as a potent nano-platform for amplified CDT.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Light-Activated Hypoxia-Sensitive Covalent Organic Framework for Tandem-Responsive Drug Delivery

Lei Ge et al.

Summary: COFs have been synthesized with hypoxia-responsive azo bonds containing photosensitizers and hypoxia-activated drugs for drug delivery. Upon exposure to hypoxic conditions and NIR light, the COF structure is disrupted, leading to drug release and activation of the hypoxia-activated drug, resulting in effective cancer cell killing and tumor growth inhibition.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Doxorubicin-Loaded MnO2@Zeolitic Imidazolate Framework-8 Nanoparticles as a Chemophotothermal System for Lung Cancer Therapy

Cheng Tan et al.

Summary: The study introduced Doxorubicin-loaded MnO2@zeolitic imidazolate framework-8 (DOX/MnO2@ZIF-8) nanoparticles for lung cancer treatment. Results showed that the nanoparticles had excellent photothermal conversion effect both in vitro and in vivo, and could effectively release drugs to inhibit the cell viability of lung cancer cells.

ACS OMEGA (2021)

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Article Biophysics

Hyaluronic acid coating on the surface of curcumin-loaded ZIF-8 nanoparticles for improved breast cancer therapy: An in vitro and in vivo study

Shaoxuan Yu et al.

Summary: The study successfully synthesized Cur-loaded and HA-coated ZIF-8 nanoparticles, which showed better stability and anticancer activities in breast cancer therapy, with a greater inhibitory effect on breast cancer and potential as an effective agent.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Pharmacology & Pharmacy

Enzyme/GSH dual-responsive biodegradable nanohybrid for spatiotemporally specific photodynamic and hypoxia-augmented therapy against tumors

Di Cheng et al.

Summary: A multitherapy modality integrating PDT, hypoxia-activated chemotherapy, and a nanocarrier was developed to address the issue of tumor hypoxia. The nanohybrid showed a tendency to accumulate and be retained in tumors, resulting in a high tumor inhibition rate.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Physical

Redox-responsive hyaluronic acid-based nanoparticles for targeted photodynamic therapy/chemotherapy against breast cancer

Rujuan Wang et al.

Summary: Hyaluronic acid combined with cystamine to form nanoparticles showed improved uptake and drug release in tumor cells, indicating great potential for enhancing cancer treatment outcomes.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Chemistry, Inorganic & Nuclear

MnO2 decorated ZIF-8@GOx for synergistic chemodynamic and starvation therapy of cancer

Jie Wang et al.

Summary: The study developed a nanoplatform by decorating MnO2 nanodots, which showed impressive performance in killing cancer cells by combining chemodynamic and cell starvation therapy. This method utilizes oxidative stress therapy and starvation therapy on tumor cells, providing a new prospect for cancer treatment.

JOURNAL OF SOLID STATE CHEMISTRY (2021)

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Article Materials Science, Biomaterials

Novel semiconducting nano-agents incorporating tirapazamine for imaging guided synergistic cancer hypoxia activated photo-chemotherapy

Guorong Zhang et al.

Summary: ITTC NPs, a novel type of nanoparticles, demonstrate excellent synergistic tumor ablation through photothermal therapy, photodynamic therapy and hypoxia-activated chemotherapy with great passive targeting ability to the tumor site.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Materials Science, Biomaterials

Encapsulating an acid-activatable phthalocyanine-doxorubicin conjugate and the hypoxia-sensitive tirapazamine in polymeric micelles for multimodal cancer therapy

Xuejiao Guo et al.

Summary: ZnPc and Dox were conjugated and encapsulated into polymeric micelles, showing excellent stability and cytotoxicity against HT29 cells.

BIOMATERIALS SCIENCE (2021)

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Review Medicine, Research & Experimental

Multifunctional nanoplatforms co-delivering combinatorial dual-drug for eliminating cancer multidrug resistance

Xiao Wei et al.

Summary: The primary cause of chemotherapy failure is cancer multidrug resistance (MDR), leading to recurrence and metastasis of cancer. Dual-therapeutic combination using multifunctional nanoplatforms is gaining attention for overcoming resistant cancers. Smart co-delivery nanocarriers can improve drug properties, enhance therapeutic efficacy, and even overcome drug resistance.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

Combination of long-acting TRAIL and tumor cell-targeted photodynamic therapy as a novel strategy to overcome chemotherapeutic multidrug resistance and TRAIL resistance of colorectal cancer

Tianshan She et al.

Summary: Chemotherapeutic multidrug resistance (MDR) and TRAIL resistance are common in colorectal cancer (CRC) cells. Combination therapy of long-acting TRAIL and tumor-cell targeted photodynamic therapy (PDT) shows promising results in combating CRC with both types of resistance.

THERANOSTICS (2021)

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Article Chemistry, Applied