4.7 Review

Current and future treatment of amyloid diseases

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AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2011)

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Article Cell Biology

Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

Mamoun M. Alhamadsheh et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Article Biochemistry & Molecular Biology

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P. T. Sattianayagam et al.

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Article Biochemistry & Molecular Biology

Suppression of choroid plexus transthyretin levels by antisense oligonucleotide treatment

Merrill D. Benson et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2010)

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

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Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

Stephen Connelly et al.

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JOURNAL OF ALZHEIMERS DISEASE (2010)

Article Gastroenterology & Hepatology

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Article Clinical Neurology

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Isabel Conceicao et al.

MUSCLE & NERVE (2010)

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Sungwook Choi et al.

NATURE CHEMICAL BIOLOGY (2010)

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Juris J. Liepnieks et al.

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Barbas Do Amaral et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2009)

Review Biochemistry & Molecular Biology

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Evan T. Powers et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

Review Clinical Neurology

Amyloid imaging in aging and dementia: Testing the amyloid hypothesis in vivo

G. D. Rabinovici et al.

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Article Biochemistry & Molecular Biology

Anti-Amyloid Activity of the C-Terminal Domain of proSP-C against Amyloid β-Peptide and Medin

Charlotte Nerelius et al.

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Article Biochemistry & Molecular Biology

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

Ehud Cohen et al.

Article Biochemistry & Molecular Biology

Preventing Amyloid Formation by Catching Unfolded Transmembrane Segments

H. Johansson et al.

JOURNAL OF MOLECULAR BIOLOGY (2009)

Editorial Material Clinical Neurology

HIGHLY SELECTIVE LEPTOMENINGEAL AMYLOIDOSIS WITH TRANSTHYRETIN VARIANT ALA25THR

K. Hagiwara et al.

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Article Biochemistry & Molecular Biology

Heterogeneity of penetrance in familial amyloid polyneuropathy, ATTR Val30Met, in the Swedish population

Urban Hellman et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2008)

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A new Thr49Pro transthyretin gene mutation associated with leptomeningeal amyloidosis

Kazuma Nakagawa et al.

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William E. Balch et al.

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Review Cell Biology

Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide

Christian Haass et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Clinical Neurology

A novel amyloidogenic transthyretin variant, Gly53Ala, associated with intermittent headaches and ataxia

C. Douglass et al.

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Review Clinical Neurology

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Verena H. Finder et al.

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Article Biochemistry & Molecular Biology

Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis

Yoshiki Sekijima et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2006)

Article Surgery

Iatrogenic amyloid neuropathy in a Japanese patient after sequential liver transplantation

T. Goto et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2006)

Article Biochemistry & Molecular Biology

Cell based screening of inhibitors of transthyretin aggregation

Natalia Reixach et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Multidisciplinary Sciences

Opposing activities protect against age-onset proteotoxicity

Ehud Cohen et al.

SCIENCE (2006)

Article Multidisciplinary Sciences

Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis

NS Green et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Letter Medicine, General & Internal

Transmission of systemic transthyretin amyloidosis by means of domino liver transplantation

AJ Stangou et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Chemistry, Multidisciplinary

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: Kinetic stabilization of the native state

HM Petrassi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Article Chemistry, Multidisciplinary

Kinetic stabilization of an oligomeric protein by a single ligand binding event

RL Wiseman et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Article Endocrinology & Metabolism

Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in β-cells

L Marzban et al.

ENDOCRINOLOGY (2005)

Article Chemistry, Medicinal

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation

SM Johnson et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Review Biochemistry & Molecular Biology

Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective

RE Tanzi et al.

Article Chemistry, Medicinal

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

H Razavi et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Article Multidisciplinary Sciences

Recognition of transmembrane helices by the endoplasmic reticulum translocon

T Hessa et al.

NATURE (2005)

Article Biochemistry & Molecular Biology

Seeding specificity in amyloid growth induced by heterologous fibrils

B O'Nuallain et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture

N Reixach et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Cell Biology

Roles of molecular chaperones in protein misfolding diseases

JM Barral et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2004)

Article Chemistry, Medicinal

Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis

SL Adamski-Werner et al.

JOURNAL OF MEDICINAL CHEMISTRY (2004)

Article Neurosciences

Synaptic targeting by Alzheimer's-related amyloid β oligomers

PN Lacor et al.

JOURNAL OF NEUROSCIENCE (2004)

Article Biochemistry & Molecular Biology

Transthyretin aggregation under partially denaturing conditions is a downhill polymerization

AR Hurshman et al.

BIOCHEMISTRY (2004)

Review Multidisciplinary Sciences

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CM Dobson

NATURE (2003)

Review Multidisciplinary Sciences

Folding proteins in fatal ways

DJ Selkoe

NATURE (2003)

Article Chemistry, Multidisciplinary

Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization

NS Green et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

Article Multidisciplinary Sciences

Prevention of transthyretin amyloid disease by changing protein misfolding energetics

P Hammarström et al.

SCIENCE (2003)

Article Chemistry, Multidisciplinary

Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation, and mechanism of action

H Razavi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)

Article Multidisciplinary Sciences

A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR

AT Petkova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Sequence-dependent denaturation energetics:: A major determinant in amyloid disease diversity

P Hammarström et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Multidisciplinary Sciences

Neurodegenerative disease - Amyloid pores from pathogenic mutations

HA Lashuel et al.

NATURE (2002)

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BRICHOS:: a conserved domain in proteins associated with dementia, respiratory distress and cancer

L Sánchez-Pulido et al.

TRENDS IN BIOCHEMICAL SCIENCES (2002)

Review Biochemistry & Molecular Biology

Biogenesis and metabolism of Alzheimer's disease Aβ amyloid peptides

G Evin et al.

PEPTIDES (2002)

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Trans-suppression of misfolding in an amyloid disease

P Hammarström et al.

SCIENCE (2001)

Article Biochemistry & Molecular Biology

An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured

X Jiang et al.

BIOCHEMISTRY (2001)

Review Biochemistry & Molecular Biology

Transthyretin: a review from a structural perspective

JA Hamilton et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2001)

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Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma

HE Purkey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Prediction of amyloid fibril-forming proteins

Y Kallberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

A comparative analysis of 23 structures of the amyloidogenic protein transthyretin

A Hörnberg et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)

Article Chemistry, Multidisciplinary

Structure-based design of N-phenyl phenoxazine transthyretin amyloid fibril inhibitors

HM Petrassi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)