期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 219, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jpba.2022.114950
关键词
NMR; GC -MS; FT-IR; Drug detection; Harm reduction
资金
- Natural Sciences and Engineering Research Council of Canada [396154510]
- Fonds de Recherche du queuebec-Nature et Technologie [206375]
In this study, three in-situ techniques, GC-MS, H-1 NMR, and FT-IR spectroscopy, were used to qualitatively analyze 318 drug samples. The majority of samples consisted of a single component, with cocaine being the most prevalent. Some samples were found to be adulterated cocaine, consisting of two or more components.
Rapid analysis of surrendered or seized drug samples provides important intelligence for health (e.g. treatment or harm reduction), and custodial services. Herein, three in-situ techniques, GC-MS, H-1 NMR and FT-IR spectroscopy, with searchable libraries, are used to analyse 318 samples qualitatively, using technique specific library -based searches, obtained over the period 24th - 29th August 2019. 259 samples were identified as consisting of a single component, of which cocaine was the most prevalent (n = 158). Median match scores for all three techniques were >= 0.84 and showed agreement except for metformin (n = 1), oxandrolone (identified as vitamin K by IR (n = 4)), diazepam (identified as zolpidem by FT-IR (n = 2)) and 2-Br-4,5-DMPEA (n = 1), a structural isomer of 2C-B identified as a polymer of cellulose (cardboard) by FT-IR. 51 samples were found to consist of two or more components, of which 49 were adulterated cocaine samples (45 binary and 4 tertiary samples). GC-MS identified all components present in the 49 adulterated cocaine samples, whereas IR identified only cocaine in 88 % of cases (adulterant only = 12 %). The breakdown for 1H NMR spectroscopy was all components identified (51 %), cocaine only (33 %), adulterant only (10 %), cocaine and one adulterant (tertiary mixtures only, 6 %).
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