4.7 Article

The proteome of clear cell ovarian carcinoma

期刊

JOURNAL OF PATHOLOGY
卷 258, 期 4, 页码 325-338

出版社

WILEY
DOI: 10.1002/path.6006

关键词

clear cell ovarian carcinoma; proteomics; epithelial ovarian carcinoma; high-grade serous ovarian carcinoma; endometrioid ovarian carcinoma; immunohistochemistry

资金

  1. Canadian Cancer Society (Impact grant) [705647]
  2. Canadian Institutes of Health Research [154290]
  3. VGH and UBC Hospital Foundation
  4. BC Cancer Foundation
  5. Terry Fox Research Institute and Ovarian Cancer Canada
  6. Vanier Canada graduate scholarship
  7. UBC-BCCA MD/PhD studentship
  8. Dr. Chew Wei Memorial Professorship in Gynecologic Oncology
  9. Canada Research Chairs program (Research Chair in Molecular and Genomic Pathology)

向作者/读者索取更多资源

Clear cell ovarian carcinoma (CCOC) has distinct proteomic differences compared with other subtypes of epithelial ovarian carcinoma, and potentially significant proteomic subgroups within CCOC, suggesting the possibility of stratified treatment for this cancer.
Clear cell ovarian carcinoma (CCOC) is the second most common subtype of epithelial ovarian carcinoma. Late-stage CCOC is not responsive to gold-standard chemotherapy and results in suboptimal outcomes for patients. In-depth molecular insight is urgently needed to stratify the disease and drive therapeutic development. We conducted global proteomics for 192 cases of CCOC and compared these with other epithelial ovarian carcinoma subtypes. Our results showed distinct proteomic differences in CCOC compared with other epithelial ovarian cancer subtypes including alterations in lipid and purine metabolism pathways. Furthermore, we report potential clinically significant proteomic subgroups within CCOC, suggesting the biologic plausibility of stratified treatment for this cancer. Taken together, our results provide a comprehensive understanding of the CCOC proteomic landscape to facilitate future understanding and research of this disease. (c) 2022 The Pathological Society of Great Britain and Ireland.

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