期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 87, 期 19, 页码 13300-13307出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c00893
关键词
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资金
- National Natural Science Foundation of China [21971224, 22071222, 22171249]
- Natural Science Foundation of Henan Province [202300410375]
A metal-free and base-free cyclization reaction was developed for the synthesis of diverse polyheterocyclic-fused quinoline-2-thiones. This protocol offers the advantages of using a green solvent, no requirement for a metal and base, short reaction time consumption, and facile isolation via simple filtration. Furthermore, it demonstrates outstanding synthetic scalability.
A metal-free and base-free cyclization reaction of ortho-heteroaryl anilines with isothiocyanatobenzene for the synthesis of diverse polyheterocyclic-fused quinoline-2-thiones was developed in PEG-200. This protocol features green solvent, lack of requirement for a metal and base, short reaction time consumption, and facile isolation via simple filtration. Furthermore, this protocol is easy to scale up which demonstrates outstanding synthetic scalability.
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