期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 88, 期 12, 页码 7755-7763出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c01369
关键词
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资金
- Ministry of Education (MOE) of Singapore
- National University of Singapore
- National Natural Science Foundation of China
- [A-0004103-00-00]
- [A-0008372-00-00]
- [22001203]
A novel cobalt/zinc bimetallic catalysis system was developed for the efficient and enantioselective synthesis of tertiary propargylic alcohols. The system utilized commercially available catalysts and achieved high yields and good enantioselectivities.
We present herein a novel cobalt/zinc bimetallic catalysis system for the realization of an efficient and enantioselective alkynylation of isatins and alpha-ketoesters using terminal alkynes. By using a simple procedure with all commercially available catalysts, including cobalt bromide, a chiral bisphosphine ligand, and zinc triflate, a range of synthetically useful tertiary propargylic alcohols are accessed with high yields and good enantioselectivities. Control reactions showed that this catalytic system proceeds through activation of the terminal alkyne by zinc triflate and a base, transmetalation from zinc to cobalt, and then the enantio-determining alkynylation of ketones.
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