Heteroatom-Assisted Regio- and Stereoselective Palladium- Catalyzed Carboxylation of 9-Allyl Adenine

Strategy for the synthesis of acyclic nucleoside analogs of biological relevance via highly regio-and stereoselective C-H functionalization employing heteroatom-assisted palladium catalyzed carboxylation of 9-allyl adenine is disclosed. Substrate scope with different carboxylic acids was performed giving decent to good yields of the desired products. The method also allowed for the synthesis of deuterated analogs.

Automated summary

A strategy for synthesizing acyclic nucleoside analogs of biological relevance through highly regio- and stereoselective C-H functionalization using heteroatom-assisted palladium catalysis of 9-allyl adenine is disclosed. The method allows for the use of different carboxylic acids in the substrate scope, resulting in decent to good yields of the desired products. The method also permits the synthesis of deuterated analogs.