Photoredox-Catalyzed Acyl Lactonization of Alkenes with Aldehydes: Synthesis of Acyl Lactones

An acyl lactonization of alkenes with aldehydes under visible-light photoredox catalysis is described. With the protocol, a broad scope of alkenoic acids and aldehydes could be compatible and good functional group tolerance is obtained. A series of acyl lactones are obtained with isolated yields ranging from 50-95%. Mechanistic studies revealed that the transformation should proceed via a radical chain process.

Automated summary

An acyl lactonization of alkenes with aldehydes under visible-light photoredox catalysis was described, showing broad scope and good functional group tolerance with isolated yields ranging from 50-95%. Mechanistic studies revealed that the transformation proceeds via a radical chain process.