Sodium butyrate modulates blood pressure and gut microbiota in maternal tryptophan-free diet-induced hypertension rat offspring

Article Nutrition & Dietetics

The Gut Microbiota Activates AhR Through the Tryptophan Metabolite Kyn to Mediate Renal Cell Carcinoma Metastasis

Guoyu Dai et al.

Summary: The tryptophan metabolite Kyn can activate AhR and promote cell migration and invasion in RCC. The gut microbiota of RCC patients is disordered, with an increased proportion of Kyn.

FRONTIERS IN NUTRITION (2021)

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Article Plant Sciences

Endogenous indole-3-acetamide levels contribute to the crosstalk between auxin and abscisic acid, and trigger plant stress responses in Arabidopsis

Marta-Marina Perez-Alonso et al.

Summary: AMI1 plays a crucial role in plant growth by helping plants adapt to abiotic stresses through balancing auxin. Functional impairment of AMI1 leads to increased susceptibility to stress, with mutant plants showing slightly repressed growth but enhanced ABA accumulation, suggesting a role for AMI1 in the crosstalk between auxin and ABA.

JOURNAL OF EXPERIMENTAL BOTANY (2021)

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Article Biochemistry & Molecular Biology

Altered Gut Microbiota and Its Metabolites in Hypertension of Developmental Origins: Exploring Differences between Fructose and Antibiotics Exposure

Chien-Ning Hsu et al.

Summary: The study found that high-fructose diet and minocycline treatment, both individually and combined, resulted in elevated blood pressure in adult male offspring, with no synergistic effect between the two. Different groups showed distinct enterotypes. Minocycline treatment increased the F/B ratio but decreased the abundance of genera Lactobacillus, Ruminococcus, and Odoribacter. Additionally, minocycline treatment led to lower levels of plasma acetic acid and butyric acid.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Targeting the Renin-Angiotensin-Aldosterone System to Prevent Hypertension and Kidney Disease of Developmental Origins

Chien-Ning Hsu et al.

Summary: The renin-angiotensin-aldosterone system (RAAS) is involved in hypertension and kidney disease, with early insults potentially leading to renal programming and adult onset of these conditions. Interventions targeting RAAS may reverse programming processes and prevent the occurrence of diseases, highlighting the importance of understanding and clinical translation of RAAS in renal programming.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Maternal resveratrol therapy protected adult rat offspring against hypertension programmed by combined exposures to asymmetric dimethylarginine and trimethylamine-N-oxide

Chien-Ning Hsu et al.

Summary: Resveratrol has been shown to protect adult offspring from hypertension programmed by prenatal exposure to ADMA and TMAO, potentially through regulation of gut microbiota, fecal butyrate levels, modulation of the renin-angiotensin system, and the nitric oxide pathway.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

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Review Nutrition & Dietetics

Cardiovascular Diseases of Developmental Origins: Preventive Aspects of Gut Microbiota-Targeted Therapy

Chien-Ning Hsu et al.

Summary: Research has shown a link between early gut microbiota and cardiovascular diseases, leading to targeted therapies such as probiotics, prebiotics, and postbiotics. Reprogramming interventions targeting the gut microbiota have shown promise in preventing cardiovascular diseases. Further studies will be needed to fully implement these findings into practice.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences