期刊
CARBOHYDRATE POLYMERS
卷 118, 期 -, 页码 209-217出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.10.076
关键词
Liposome; Carboxymethyl dextran; Controlled release; Magnetic resonance imaging; Doxorubicin
资金
- National Natural Science Foundation of China [21374133, 21276285, 21104096]
- Hunan Provincial Natural Science Foundation of China [12JJ4014]
The aim of this work was to construct carboxymethyl dextran (CMD)-coated magnetoliposomes (MLs), another stealth MLs alternative to PEGylated MLs, for theranostic application. Particularly, the on-demand release of CMD-MLs under low-frequency alternating magnetic field (LF-AMF) was studied. We found that as-prepared MLs exhibited good stability and high drug loading ability for doxorubicin (DOX). Cytotoxicity assay against human neuroblastoma SH-SY5Y cells showed that the DOX-loaded CMD-MLs were less toxic than free DOX due to the sustained release of DOX. However, the release of DOX-loaded CMD-MLs was enhanced by low-frequency alternating magnetic field without hyperthermia generation. The MLs also acted as an efficient T-2-weighted contrast agent during in vitro MRI measurements. The above results provide useful information on in vivo diagnostic/therapeutic efficacy of DOX-loaded CMD-MLs for some cancers, such as brain cancers. (C) 2014 Elsevier Ltd. All rights reserved.
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