期刊
JOURNAL OF NEUROSCIENCE
卷 42, 期 44, 页码 8284-8296出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0416-22.2022
关键词
brain; cortex; early life; c oscillation; neonatal; pain
资金
- Biotechnology and Biological Sciences Research Council [BB/R00823X/1]
- Medical Research Council [MR/L019248/1]
Early life pain experience alters adult pain behavior and hypersensitivity, affecting functional brain connectivity.
Early life pain (ELP) experience alters adult pain behavior and increases injury-induced pain hypersensitivity, but the effect of ELP on adult functional brain connectivity is not known. We have performed continuous local field potential (LFP) recording in the awake adult male rats to test the effect of ELP on functional cortical connectivity related to pain behavior. Primary somatosensory cortex (S1) and medial prefrontal cortex (mPFC) LFPs evoked by mechanical hindpaw stimulation were recorded simultaneously with pain reflex behavior for 10 d after adult incision injury. We show that, after adult injury, sensory evoked S1 LFP 45 and c energy and S1 LFP 45/c frequency coupling are significantly increased in ELP rats compared with controls. Adult injury also induces increases in S1-mPFC functional connectivity, but this is significantly prolonged in ELP rats, lasting 4 d compared with 1 d in controls. Importantly, the increases in LFP energy and connectivity in ELP rats were directly correlated with increased behavioral pain hypersensitivity. Thus, ELP alters adult brain functional connectivity, both within and between cortical areas involved in sensory and affective dimensions of pain. The results reveal altered brain connectivity as a mechanism underlying the effects of ELP on adult pain perception.
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