期刊
JOURNAL OF NEUROENDOCRINOLOGY
卷 34, 期 10, 页码 -出版社
WILEY
DOI: 10.1111/jne.13201
关键词
fertility; kisspeptin; neurokinin B; reproduction
资金
- MRC Clinical Research Training Fellowship [MR/T006242/1]
- NIHR Imperial Biomedical Research Centre
- NIHR Senior Investigator Award
This review focuses on the latest research on reproductive neuropeptides kisspeptin and neurokinin B, highlighting their potential applications in managing reproductive disorders.
The reproductive neuropeptide kisspeptin has emerged as the master regulator of mammalian reproduction due to its key roles in the initiation of puberty and the control of fertility. Alongside the tachykinin neurokinin B and the endogenous opioid dynorphin, these peptides are central to the hormonal control of reproduction. Building on the expanding body of experimental animal models, interest has flourished with human studies revealing that kisspeptin administration stimulates physiological reproductive hormone secretion in both healthy men and women, as well as patients with common reproductive disorders. In addition, emerging therapeutic roles based on neurokinin B for the management of menopausal flushing, endometriosis and uterine fibroids are increasingly recognised. In this review, we focus on kisspeptin and neurokinin B and their potential application as novel clinical strategies for the management of reproductive disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据