期刊
JOURNAL OF NEURAL ENGINEERING
卷 19, 期 5, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1741-2552/ac8e32
关键词
computational modeling; retinal electric field distribution; trans-corneal electrical stimulation; ERG-Jet electrode; DTL-Plus electrode; lateralization
资金
- National Natural Science Foundation of China [62073221, 62103269, 61971280, 61671300]
- China Postdoctoral Science Foundation [2019M661509]
- Med-X Research Fund of Shanghai Jiao Tong University [YG2022QN077]
- National Key R&D Program of China [2021YFD1400102]
In this study, the researchers constructed a realistic finite element human head model to investigate the effect of different electrode configurations and stimulation parameters on the electric field distribution on the retina. They found that re-designing the TcES electrode settings and stimulus parameters could modulate the electric field distribution, and further adjusting the lateralization of the retina observation surface (ROS).
Objective. Trans-corneal electrical stimulation (TcES) produces therapeutic effects on many ophthalmic diseases non-invasively. Existing clinical TcES devices use largely variable design of electrode distribution and stimulation parameters. Better understanding of how electrode configuration paradigms and stimulation parameters influence the electric field distribution on the retina, will be beneficial to the design of next-generation TcES devices. Approach. In this study, we constructed a realistic finite element human head model with fine eyeball structure. Commonly used DTL-Plus and ERG-Jet electrodes were simulated. We then conducted in silico investigations of retina observation surface (ROS) electric field distributions induced by different return electrode configuration paradigms and different stimulus intensities. Main results. Our results suggested that the ROS electric field distribution could be modulated by re-designing TcES electrode settings and stimulus parameters. Under far return location paradigms, either DTL-Plus or ERG-Jet approach could induce almost identical ROS electric field distribution regardless where the far return was located. However, compared with the ERG-Jet mode, DTL-Plus stimulation induced stronger nasal lateralization. In contrast, ERG-Jet stimulation induced relatively stronger temporal lateralization. The ROS lateralization can be further tweaked by changing the DTL-Plus electrode length. Significance. These results may contribute to the understanding of the characteristics of DTL-Plus and ERG-Jet electrodes based electric field distribution on the retina, providing practical implications for the therapeutic application of TcES.
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