期刊
JOURNAL OF NATURAL PRODUCTS
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.2c00682
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资金
- National Research Foundation of Korea (NRF) [2021M3H9A103743912]
- KRIBB Research Initiative Program - Ministry of Science ICT (MSIT) [KGM5292221, KGM1222211]
- Basic Science Research Program of the Ministry of Education of the Republic of Korea [2021R1I1A204970412]
In this study, a new secondary metabolite, ulleungdolin, was isolated from the co-culture of an actinomycete and a fungus. Ulleundolin exhibited antimigration effect on breast cancer cells.
A new secondary metabolite, ulleungdolin (1), was isolated from the co-culture of an actinomycete, Streptomyces sp. 13F051, and a fungus, Leohumicola minima 15S071. Based on the NMR, UV, and MS data, it was deduced that the planar structure of 1 comprised an isoindolinone (IsoID) with an octanoic acid, a tripeptide, and a sugar. The tripeptide has the unprecedented amino acids norcoronamic acid, 3-hydroxy-glutamine, and 4-hydroxy-phenylglycine and is linked by a C-N bond with IsoID. The absolute configurations were determined by chemical derivatization, extensive spectro-scopic methods, and electronic circular dichroism calculations and supported by bioinformatic analyses. Bioactivity evaluation studies indicated that 1 had an antimigration effect on MDA-MB-231 breast cancer cells.
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