Synthesis, XRD, Hirshfeld surface analysis, DFT studies, cytotoxicity and anticancer activity of di(m-chlorobenzyl) (dichloro) (4, 7-diphenyl-1,10-phenanthroline) tin (IV) complex

The complex di(m-chlorobenzyl) (dichloro) (4, 7-diphenyl-1,10-phenanthroline) tin (IV) complex ( B2) was synthesized and characterized by FT-IR, FT-Raman, H-1 NMR, C-13 NMR, 119Sn NMR, and XRD. The above-synthesized complex compared with the theoretical method using Gaussian software at DFT/B3LYP/Lanl2DZ. Wavefunctiona based properties like ELF and LOL helped to identify the electron distributions. X-ray study confirmed that compound crystallizes in monoclinic space group with P2(1)/c,. The crystal structure of the B2 shows a regular octahedral geometry.Hydrogen bond formation is observed through chlorine anion via C -H-Cl. The complex showed excellent cytotoxicity and anticancer activity against Vero and Hela cell line when compared to the standard drug cisplatin.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

The complex di(m-chlorobenzyl)(dichloro)(4,7-diphenyl-1,10-phenanthroline) tin(IV) complex (B2) was synthesized and characterized. The structure of B2 was determined to be regular octahedral geometry through X-ray study. The complex exhibited excellent cytotoxicity and anticancer activity against Vero and Hela cell lines.