A review: Structure-activity relationship and antibacterial activities of Quinoline based hybrids

The drug resistance problem is most acute in the case of bacteria. There is always a need to develop novel antibacterial drugs with better mechanisms of action. Most of the quinoline-based antibiotics developed are potential antibacterial drug candidates. This review represents quinoline-based hybrids with antibacterial activity and their structure-activity relationship (SAR), which provide further insight into the improvement of quinoline-based antibiotics especially against multidrug-resistant bacterial strains. (C) 2022 Elsevier B.V. All rights reserved.

Automated summary

This review summarizes quinoline-based hybrids with antibacterial activity and their structure-activity relationship (SAR), providing insights into the improvement of quinoline-based antibiotics, especially against multidrug-resistant bacterial strains.