期刊
CARBOHYDRATE POLYMERS
卷 122, 期 -, 页码 69-76出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.12.067
关键词
Wound healing; Collagenolytic activity; Biocompatibility; Cytotoxicity; Cell adhesion; Immobilization
资金
- CNPq [402468/2013-9]
- CAPES
- CNPq
This work presents the development of a new bioactive material for wound therapeutics which may play a dual role of modulate metallo proteinases activity while prevents infection blocking out pathogenic microorganisms and foreign materials. A CGP/PVA film was activated by covalent immobilization of trypsin. Results from biocompatibility test revealed that PDL fibroblasts grown on the surface of CGP/PVA and the high amount of viable cells proved absence of cytotoxicity. Trypsin immobilized onto CGP/PVA film remained 100% active after 28 days stored dried at room temperature. In addition, CGP/PVA-trypsin film could be used for 9 cycles of storage/use without loss of activity. After immobilization, trypsin retained its collagenolytic activity, indicating this material as a promising material for wound dressing applications. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据