☆ 4.4 Article

Distinct Molecular Mechanisms Characterizing Pathogenesis of SARS-CoV-2

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target

Gergely Rona et al.

Summary: A novel NSP14-NSP10 inhibitor, sofalcone, was found to enhance the efficacy of remdesivir and exhibit inhibitory activity against various coronaviruses in vitro. This provides proof-of-concept for the NSP14 complex as a therapeutic target.

CELL DEATH AND DIFFERENTIATION (2022)

添加到收藏夹

Article Respiratory System

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

Konstantinos Evangelou et al.

Summary: This study found that SARS-CoV-2 infection in severe COVID-19 patients leads to cellular senescence and a proinflammatory phenotype in AT2 cells. In vitro experiments showed that SARS-CoV-2 infection induces cell senescence and inflammation. Infected senescent cells may contribute to SARS-CoV-2 mutagenesis mediated by APOBEC enzymes.

EUROPEAN RESPIRATORY JOURNAL (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Activation of the SARS-CoV-2 NSP14 3′-5′ exoribonuclease by NSP10 and response to antiviral inhibitors

Amanda A. Riccio et al.

Summary: Understanding the core replication complex of SARS-CoV-2 is crucial for the development of antiviral therapeutics. The researchers developed a simple protocol for the expression and purification of NSP10 and NSP14, and successfully assembled a purified NSP10/14 complex. They found that NSP10 enhances the activity and stability of NSP14. The study also investigated the effects of two small molecules on NSP10/14 activity.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

添加到收藏夹

Review Immunology

Proteolytic activation of SARS-CoV-2 spike protein

Makoto Takeda

Summary: This review discusses the crucial role of S protein cleavage in coronavirus infection, particularly focusing on SARS-CoV-2. The complexity of the cleavage activation mechanism of the S protein is highlighted, with different cleavage sites and motifs involved. Variants of concern with enhanced infectivity have emerged during the ongoing pandemic, demonstrating the significant impact of changes in S protein cleavability on viral infectivity and virulence.

MICROBIOLOGY AND IMMUNOLOGY (2022)

添加到收藏夹

Review Cell Biology

Mechanisms of SARS-CoV-2 entry into cells

Cody B. Jackson et al.

Summary: The entry of SARS-CoV-2 into host cells is facilitated by the interaction between the viral spike protein and ACE2, leading to virus-cell membrane fusion, which has been extensively studied at the structural and cellular levels worldwide. This understanding has paved the way for the development of effective vaccines in response to the COVID-19 pandemic, caused by the infection with SARS-CoV-2.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN

Nicholas H. Moeller et al.

Summary: This study reveals the structure of the ExoN protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which plays a crucial role in the accurate replication of the virus's RNA genome. The structure demonstrates how ExoN binds to its cofactor nsp10 and interacts with RNA substrates. The findings have implications for the development of antiviral drugs and strategies to mitigate the virulence of coronaviruses.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

添加到收藏夹

Article Virology

Identifying Inhibitors of-1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses

Sneha Munshi et al.

Summary: Recurrent outbreaks of novel zoonotic coronavirus diseases in recent years have emphasized the importance of developing therapeutics with broad-spectrum activity against coronaviruses. Researchers explored whether small-molecule inhibitors of -1 programmed ribosomal frameshifting in SARS-CoV-2 also inhibited this process in a range of bat coronaviruses. The results showed that some drugs had strong activity against a broad spectrum of coronaviruses, establishing frameshift signals as a viable target for developing pan-coronaviral therapeutics.

VIRUSES-BASEL (2022)

添加到收藏夹

Article Microbiology

SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment

Chao Shang et al.

Summary: Mitochondria are closely involved in SARS-CoV-2 replication, and mitochondrial homeostasis is disrupted by the virus. The virus can inhibit autophagy as an anti-autophagy strategy, while mitochondria initiate mitophagy for quality control and virus clearance.

FRONTIERS IN MICROBIOLOGY (2022)

添加到收藏夹

Article Immunology

Reinfection With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Patients Undergoing Serial Laboratory Testing

Adnan Qureshi et al.

Summary: Reinfection with SARS-CoV-2 is rare but has been associated with mortality. The severity of reinfection appears to be milder, with fewer cases of severe illness compared to primary infection. Risk factors for reinfection include asthma and nicotine dependence/tobacco use.

CLINICAL INFECTIOUS DISEASES (2022)

添加到收藏夹

Review Microbiology

SARS-CoV-2: Receptor and Co-receptor Tropism Probability

Narges Eslami et al.

Summary: This article investigates the mechanisms of SARS-CoV-2 entry into cells, including the roles of receptors, co-receptors, and other molecular factors. Understanding the pathogenesis of COVID-19 can help prevent and treat the disease, especially in vulnerable individuals.

CURRENT MICROBIOLOGY (2022)

添加到收藏夹

Article Immunology

Laboratory Diagnosis for SARS-CoV-2 Infection

Bianca B. Christensen et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mechanisms of Antiviral Immune Evasion of SARS-CoV-2

Daniel Beyer et al.

Summary: This article summarizes the mechanisms by which SARS-CoV-2 antagonizes interferon production and signaling to establish productive infection. Understanding host-pathogen interactions is critical for managing COVID-19.

JOURNAL OF MOLECULAR BIOLOGY (2022)

添加到收藏夹

Letter Medicine, General & Internal

SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses

Maaike C. Swets et al.

LANCET (2022)

添加到收藏夹

Letter Biochemistry & Molecular Biology

Studying severe long COVID to understand post-infectious disorders beyond COVID-19

Petter Brodin et al.

NATURE MEDICINE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity

Anna Czarna et al.

Summary: During RNA replication, Nsp14 plays a crucial role in error correction and protection of viral RNA. The modulatory role of the protein co-factor Nsp10 and the essential control mechanism have been revealed through structural analysis.

STRUCTURE (2022)

添加到收藏夹

Review Virology

Mutations and Evolution of the SARS-CoV-2 Spike Protein

Nicholas Magazine et al.

Summary: This review summarizes the potential mechanisms by which common mutations on the spike protein in SARS-CoV-2 variants enhance the overall fitness of the virus. Understanding how these mutations alter viral functions can help predict the effects of future mutations and assist the scientific community in addressing viral evolution.

VIRUSES-BASEL (2022)

添加到收藏夹

Article Immunology

SARS-CoV-2 reinfection and COVID-19 severity

Nhu Ngoc Nguyen et al.

Summary: The reinfection rate of SARS-CoV-2 is low, and the severity of the first and second episodes of infection is similar. The severity of the second episode of COVID-19 is not higher than that of the first infection, even for patients with antibodies.

EMERGING MICROBES & INFECTIONS (2022)

添加到收藏夹

Article Cell Biology

Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies

Miao-Miao Zhao et al.

Summary: This study identifies two previously unidentified Cathepsin L (CTSL) cleavage sites in the spike protein of SARS-CoV-2. CTSL cleavage promotes the adoption of a specific conformation by the spike protein, facilitating receptor binding and membrane fusion. Inhibitors targeting CTSL not only block viral infection in cells, but also reduce live virus infection in lung tissues. CTSL-specific inhibitors show promising effects in preventing live virus infection in animal models. Inhibition of CTSL cleavage could be a potential strategy for developing mutation-resistant therapies.

CELL DISCOVERY (2022)

添加到收藏夹

Review Virology

HIV/SARS-CoV-2 coinfection: A global perspective

Osman N. Kanwugu et al.

Summary: This review provides an overview of SARS-CoV-2 infection in PLWH, discussing whether HIV-infected individuals are at increased risk of COVID-19 and severe disease, as well as exploring the potential protective effects of antiretroviral therapy or HIV-related immunosuppression.

JOURNAL OF MEDICAL VIROLOGY (2021)

添加到收藏夹

Review Immunology

An enlightening role for cytokine storm in coronavirus infection

Zhongyi Zhao et al.

Summary: Infections by the novel coronavirus may result in cytokine storm, leading to multi-organ dysfunction and increased mortality.

CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Outcomes of Coronavirus Disease 2019 (COVID-19) Related Hospitalization Among People With Human Immunodeficiency Virus (HIV) in the ISARIC World Health Organization (WHO) Clinical Characterization Protocol (UK): A Prospective Observational Study

Anna Maria Geretti et al.

Summary: This study compared the characteristics and outcomes of COVID-19 patients with and without HIV in the UK, finding that HIV-positive individuals had a higher risk of mortality, especially in those under 60 years old. Despite similar cumulative day-28 mortality rates, HIV-positive status was associated with increased mortality after adjusting for age and other variables.

CLINICAL INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Immunology

Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient

Ji Hoon Baang et al.

Summary: This case illustrates challenges in managing immunocompromised hosts with chronic COVID-19, who may act as persistent shedders and sources of transmission. The patient's lack of seroconversion and prolonged course highlight the importance of humoral immunity in resolving viral infections.

JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling

Fei Li et al.

Summary: The study found that SARS-CoV-2 infection induces autophagy and apoptosis in cells by upregulating intracellular reactive oxygen species (ROS) levels, inhibiting the PI3K/AKT/mTOR pathway, and ultimately triggering inflammatory responses and cell apoptosis. These findings are crucial for understanding the pathogenic inflammation mechanism induced by SARS-CoV-2 infection and developing anti-inflammatory therapies for COVID-19 patients.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis

Armin Bayati et al.

Summary: SARS-CoV-2 uses spike glycoprotein for initial interaction with cell surface and undergoes clathrin-mediated endocytosis, transferring viral RNA to cell cytosol. Knockdown of clathrin heavy chain reduces viral infectivity, highlighting the importance of clathrin-mediated endocytosis in virus infectivity.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

添加到收藏夹

Article Virology

The G614 pandemic SARS-CoV-2 variant is not more pathogenic than the original D614 form in adult Syrian hamsters

Charles B. Stauft et al.

Summary: By infecting hamsters with two variants of SARS-CoV-2, this study found that there was no significant difference in pathogenicity between the naturally circulating D614 and G614 variants.

VIROLOGY (2021)

添加到收藏夹

Article Virology

SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-beta Production

Keli Chen et al.

Summary: The nucleocapsid (N) protein of SARS-CoV-2 plays a crucial role in inhibiting interferon beta production by interacting with the key component RIG-I in the RNA recognition pathway, potentially affecting the host's immune response.

VIRUSES-BASEL (2021)

添加到收藏夹

Article Microbiology

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

Tianling Ou et al.

Summary: Chloroquine and hydroxychloroquine have been shown to inhibit viral infection by targeting different pathways through which the SARS-CoV-2 spike protein is activated. SARS-CoV-2 relies more on the TMPRSS2 pathway for entry, while the presence of a furin-cleavage site in its spike protein further complicates the treatment with hydroxychloroquine alone. Combining hydroxychloroquine with a TMPRSS2 inhibitor may provide a more effective strategy to block SARS-CoV-2 infection.

PLOS PATHOGENS (2021)

添加到收藏夹

Review Immunology

Nucleic Acid-Sensing Pathways During SARS-CoV-2 Infection: Expectations versus Reality

Bushra Mdkhana et al.

Summary: The COVID-19 pandemic has had a significant impact on millions of people and economies worldwide, leading to active research on its pathobiology and the search for effective therapeutics.

JOURNAL OF INFLAMMATION RESEARCH (2021)

添加到收藏夹

Correction Biochemistry & Molecular Biology

Syncytia formation by SARS-CoV-2-infected cells (vol 39, e106267, 2020)

Julian Buchrieser et al.

EMBO JOURNAL (2021)

添加到收藏夹

Editorial Material Public, Environmental & Occupational Health

Quantifying the transmission advantage associated with N501Y substitution of SARS-CoV-2 in the UK: an early data-driven analysis

Shi Zhao et al.

Summary: The N501Y mutation in the UK is rapidly becoming prevalent and poses a major challenge for COVID-19 control. Studies show that this mutation increases the infectivity of the virus by 52%, highlighting the need for increased vigilance and control measures.

JOURNAL OF TRAVEL MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP

Katerina Naydenova et al.

Summary: The structure of the RNA polymerase inhibitor favipiravir bound to the SARS-CoV-2 RNA-dependent RNA polymerase has been determined, revealing its binding mode at the catalytic site. The inhibitor is weakly incorporated into the RNA primer strand, leading to suppression of RNA replication in the presence of natural nucleotides.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England

Nicholas G. Davies et al.

Summary: A new variant of SARS-CoV-2 has emerged in England, with a higher reproduction number and potential for large resurgences of COVID-19 cases. Without stringent control measures, it is projected that COVID-19 hospitalizations and deaths in England for the first 6 months of 2021 will exceed those in 2020. The variant has spread globally and exhibited similar transmission increases in Denmark, Switzerland, and the United States.

SCIENCE (2021)

添加到收藏夹

Article Microbiology

Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication

Bo Gao et al.

Summary: Coronaviruses use the endoribonuclease nsp15 to interfere with the formation of anti-viral stress granules (SGs), reducing viral dsRNA accumulation and antagonizing PKR activation, thereby ensuring productive virus replication. Nsp15s from various coronaviruses interfere with SGs formation, possibly by targeting essential SGs assembly factors, indicating a conserved mechanism among coronaviruses to counteract host antiviral responses. This study highlights the role of nsp15 in suppressing the integral stress response and crosstalk with anti-innate immune response.

PLOS PATHOGENS (2021)

添加到收藏夹

Review Microbiology

Innate Immunity Evasion Strategies of Highly Pathogenic Coronaviruses: SARS-CoV, MERS-CoV, and SARS-CoV-2

Jin-Yan Li et al.

Summary: The article reviews recent studies on the interference and infection process of highly pathogenic human coronaviruses (HP-hCoVs) in cells. HP-hCoVs employ various strategies to suppress immune responses, which is important for understanding the viral pathogenesis and developing antiviral therapies.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

Matthew McCallum et al.

Summary: The study identifies 41 human monoclonal antibodies that recognize the N-terminal domain of the SARS-CoV-2 spike protein and exhibit strong neutralizing activity. These antibodies inhibit cell-to-cell fusion, activate effector functions, and protect animals from virus challenge, highlighting the importance of NTD-specific neutralizing antibodies for protective immunity and vaccine development. Several SARS-CoV-2 variants with mutations in the NTD supersite suggest ongoing selective pressure on the virus.

CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant

Xianding Deng et al.

Summary: A new SARS-CoV-2 variant named B.1.427/B.1.429 was identified in California, with increased transmissibility and carrying three mutations in spike protein, including L452R substitution. The variant emerged in May 2020 and became predominant in sequenced cases from September 2020 to January 2021. In vivo viral shedding was increased and antibody neutralization decreased, calling for further investigation.

CELL (2021)

添加到收藏夹

Article Cell Biology

SARS-CoV-2 infection induces beta cell transdifferentiation

Xuming Tang et al.

Summary: Recent clinical data suggest a correlation between COVID-19 and diabetes. This study found SARS-CoV-2 viral antigen in pancreatic beta cells, leading to the possibility of cell transdifferentiation. Infection with SARS-CoV-2 can cause changes in cell fate, providing new insights into the pathomechanisms of COVID-19.

CELL METABOLISM (2021)

添加到收藏夹

Article Infectious Diseases

Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study

Dan Frampton et al.

Summary: This study describes the emergence of the B.1.1.7 variant of concern, its virological characteristics, and clinical severity in patients. Increased viral load was found in B.1.1.7 infection, but no association with severe disease was identified in the hospitalized cohort.

LANCET INFECTIOUS DISEASES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

Nuno R. Faria et al.

Summary: A new variant of concern, P.1, with 17 mutations including three spike protein mutations associated with increased binding to human ACE2 receptors, emerged in Manaus, Brazil between November 2020 and January 2021. Molecular analysis suggests P.1 may be 1.7- to 2.4-fold more transmissible and that previous infection may provide 54 to 79% protection against P.1 infection compared to other lineages. Enhanced global genomic surveillance of such variants is crucial for pandemic response.

SCIENCE (2021)

添加到收藏夹

Article Virology

The ORF8 protein of SARS-CoV-2 induced endoplasmic reticulum stress and mediated immune evasion by antagonizing production of interferon beta

Farooq Rashid et al.

Summary: The orf8 protein of SARS-CoV-2 induces ER stress by activating ATF6 and IRE1 pathways, inhibits PERK pathway, and acts as an interferon antagonist to suppress IFN beta production, which is not influenced by the genotypes of orf8L and orf8S.

VIRUS RESEARCH (2021)

添加到收藏夹

Article Virology

The Impact on Infectivity and Neutralization Efficiency of SARS-CoV-2 Lineage B.1.351 Pseudovirus

Yeong Jun Kim et al.

Summary: A new variant of SARS-CoV-2 B.1.351 lineage is of global concern for its potential increase in transmissibility and resistance to neutralizing antibodies. This study found that the B.1.351 lineage variant showed significantly increased infectivity and enhanced cell-cell fusion compared to the Wuhan strains, particularly with the K417N and E484K mutations. In terms of antibody efficacy, Imdevimab was more effective in neutralizing the B.1.351 lineage pseudoviruses containing specific mutations, compared to Casirivimab.

VIRUSES-BASEL (2021)

添加到收藏夹

Review Virology

NSP16 2′-O-MTase in Coronavirus Pathogenesis: Possible Prevention and Treatments Strategies

Li-Jen Chang et al.

Summary: This review summarizes recent life-threatening viruses and the crucial role of NSP16 protein in the coronavirus family, including its structure, function, and evasion of host immune response.

VIRUSES-BASEL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions

Xiaopan Gao et al.

Summary: Orf9b, a unique accessory protein of SARS-CoV-2 and SARS-CoV, interacts with TOM70 to potentially interfere with immunity and suppress interferon responses by inhibiting the Hsp90/TOM70 interaction. The specific mechanisms of these interactions shed light on the pathogenesis of these coronaviruses.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Cell Biology

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

Manuel Hayn et al.

Summary: SARS-CoV-2 proteins synergize to counteract innate immune responses, but they are vulnerable to type II and III interferons. Experimental results show potent inhibition of SARS-CoV-2 infection by interferon-gamma and lambda 1, highlighting potential for effective antiviral approaches.

CELL REPORTS (2021)

添加到收藏夹

Article Medicine, General & Internal

Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study

Barnaby E. Young et al.

Summary: The study found that different SARS-CoV-2 clades are associated with varying rates of hypoxia development and transmission, with L/V clade infections showing more pronounced systemic inflammation and G clade infections having higher viral loads but not increased transmissibility.

EBIOMEDICINE (2021)

添加到收藏夹

Letter Cell Biology

SARS-CoV-2 cell tropism and multiorgan infection

Jia Liu et al.

CELL DISCOVERY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The SARS-CoV-2 Programmed-1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography

Christina Roman et al.

Summary: The PFSE of SARS-CoV-2, a structured RNA conserved in all coronaviruses, promotes ribosomal frameshifting during translation, leading to production of longer polyproteins. Drugs and sequence alterations that affect the stability of PFSE disrupt the proper stoichiometry of nonstructural proteins, compromising viral replication. The high-resolution structure of PFSE provides a new conformation for mechanistic investigations and structure-based drug design.

ACS CHEMICAL BIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation

Lucy G. Thorne et al.

Summary: SARS-CoV-2 infection leads to broad-spectrum immunopathological diseases, exacerbated by inflammatory co-morbidities. Research shows that the virus replicates rapidly in lung epithelial cells and triggers a robust innate immune response, affecting macrophage activation through inflammatory mediators produced during infection. Further exacerbation of the local inflammatory environment occurs when macrophages or epithelial cells are primed with exogenous inflammatory stimuli.

EMBO JOURNAL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

Lilian Cristina Russo et al.

Summary: Research shows that the function of the SARS-CoV-2 Nsp3 macrodomain is to hydrolyze the end product of the IFN signaling pathway rather than to suppress the IFN response, from the perspective of the IFN response and ADP-ribosylation.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

添加到收藏夹

Article Virology

SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells

Keith Meyer et al.

Summary: Increased mortality in COVID-19 cases is often associated with microvascular complications. The spike protein of SARS-CoV-2 can induce cellular senescence and inflammatory responses in human epithelial cells, leading to enhanced leukocyte adhesion. Various inhibitors have shown potential in reversing the senescence effects and reducing inflammatory responses.

JOURNAL OF VIROLOGY (2021)

添加到收藏夹

Review Microbiology

SARS-CoV-2 variants, spike mutations and immune escape

William T. Harvey et al.

Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome

Kaiming Zhang et al.

Summary: A 6.9 angstrom resolution cryo-EM structure of the SARS-CoV-2 frameshift stimulation element (FSE) was successfully demonstrated in this study, guiding the development of antisense oligonucleotides that impair virus replication. The FSE, crucial for balanced expression of viral proteins, is becoming a key target for drug discovery campaigns against COVID-19.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Restriction of SARS-CoV-2 replication by targeting programmed-1 ribosomal frameshifting

Yu Sun et al.

Summary: The study found that merafloxacin can inhibit -1 PRF activity of SARS-CoV-2 and is similarly effective on other betacoronaviruses.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

Nunziata Maio et al.

Summary: Research has shown that the catalytic subunit nsp12 of the SARS-CoV-2 RdRp complex ligates two iron-sulfur metal cofactors which are essential for viral replication and interaction with the viral helicase. Oxidation of these clusters by TEMPOL inhibits RdRp activity and blocks SARS-CoV-2 replication in cell culture, indicating that these iron-sulfur clusters could be targeted for therapy of COVID-19.

SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity

Sophie M-C Gobeil et al.

Summary: SARS-CoV-2 variants with multiple spike mutations have increased transmission and resistance to antibodies. Research showed that these variants have enhanced receptor binding and a preference for receptor binding domain up states. Different variants exhibit different mechanisms for resistance to neutralizing antibodies, which helps explain their transmission and resistance.

SCIENCE (2021)

添加到收藏夹

Article Virology

A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses

Dae-Gyun Ahn et al.

Summary: Recent outbreaks of zoonotic coronaviruses, such as MERS-CoV and SARS-CoV-2, have caused significant casualties and economic shock. A novel compound, KCB261770, has been identified to effectively inhibit MERS-CoV frameshifting, showing potential as a drug candidate for interfering with pan-coronavirus frameshifting.

VIRUSES-BASEL (2021)

添加到收藏夹

Article Cell Biology

SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication

Zhou-Qin Zheng et al.

Summary: The SARS-CoV-2 nucleocapsid protein impairs stress granule formation induced by viral RNA, promoting viral replication. Deficiency of PKR or G3BP1 disrupts antiviral stress granule formation and enhances SARS-CoV-2 replication.

CELL DISCOVERY (2021)

添加到收藏夹

Article Microbiology

TLR3 and TLR7 RNA Sensor Activation during SARS-CoV-2 Infection

Daria Bortolotti et al.

Summary: (3) Our study demonstrated that both TLR3 and TLR7 play a role in regulating innate immunity during lung SARS-CoV-2 infection. Activation of TLRs led to the production of pro-inflammatory cytokines and interferons, indicating their potential as targets for early-stage infection control.

MICROORGANISMS (2021)

添加到收藏夹

Review Cell Biology

Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications

Ioannis P. Trougakos et al.

Summary: The article discusses the two-phase nature of COVID-19, highlighting the characteristics of increased virus transmission and uncontrolled inflammatory immune responses which can lead to severe complications. The focus is on approaches to suppress viral infection rates, activate adaptive immune responses, and mitigate tissue damage and cytokine storms associated with COVID-19.

JOURNAL OF BIOMEDICAL SCIENCE (2021)

添加到收藏夹

Review Infectious Diseases

SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis

Muge Cevik et al.

Summary: This study aimed to characterize the viral load dynamics, duration of viral shedding, and viable virus shedding of SARS-CoV-2 in various body fluids. The findings suggest that while SARS-CoV-2 RNA shedding can be prolonged in respiratory and stool samples, the duration of viable virus shedding is relatively short-lived.

LANCET MICROBE (2021)

添加到收藏夹

Editorial Material Gastroenterology & Hepatology

Evidence for Gastrointestinal Infection of SARS-CoV-2

Fei Xiao et al.

GASTROENTEROLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan et al.

SCIENCE (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

Canrong Wu et al.

ACTA PHARMACEUTICA SINICA B (2020)

添加到收藏夹

Review Microbiology

Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks

Hossam M. Ashour et al.

PATHOGENS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

添加到收藏夹

Review Microbiology

Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19

Annsea Park et al.

CELL HOST & MICROBE (2020)

添加到收藏夹

Article Cell Biology

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

Lihua Zhu et al.

CELL METABOLISM (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Wanchao Yin et al.

SCIENCE (2020)

添加到收藏夹

Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

Markus Hoffmann et al.

MOLECULAR CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of replicating SARS-CoV-2 polymerase

Hauke S. Hillen et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structural basis of receptor recognition by SARS-CoV-2

Jian Shang et al.

NATURE (2020)

添加到收藏夹

Article Medicine, General & Internal

Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility

M. M. Arons et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

Qianqian Li et al.

CELL (2020)

添加到收藏夹

Editorial Material Immunology

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Yujie Ren et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

添加到收藏夹

Review Critical Care Medicine

Acute kidney injury in critically ill patients with COVID-19

Paul Gabarre et al.

INTENSIVE CARE MEDICINE (2020)

添加到收藏夹

Article Infectious Diseases

Persistence of intestinal SARS-CoV-2 infection in patients with COVID-19 leads to re-admission after pneumonia resolved

Xiaorong Wang et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural and functional conservation of the programmed-1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)

Jamie A. Kelly et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

添加到收藏夹

Review Cell Biology

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts

Jin Wang et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

The protein expression profile of ACE2 in human tissues

Feria Hikmet et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

Leonid Yurkovetskiy et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Donghyuk Shin et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

A molecular pore spans the double membrane of the coronavirus replication organelle

Georg Wolff et al.

SCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structural basis of RNA cap modification by SARS-CoV-2

Thiruselvam Viswanathan et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

Na Zhu et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Virology

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2

Natacha S. Ogando et al.

JOURNAL OF VIROLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

Lisa Miorin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Cell Biology

Evasion of Type I Interferon by SARS-CoV-2

Hongjie Xia et al.

CELL REPORTS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

Hafeez S. Haniff et al.

ACS CENTRAL SCIENCE (2020)

添加到收藏夹

Letter Medicine, General & Internal

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

Bina Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

Steffen Klein et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Medicine, General & Internal

A Clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways

Ramon Lorenzo-Redondo et al.

EBIOMEDICINE (2020)

添加到收藏夹

Review Medicine, General & Internal

Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2

Francesca Salamanna et al.

FRONTIERS IN MEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy

Anna Wacker et al.

NUCLEIC ACIDS RESEARCH (2020)

添加到收藏夹

Article Cell Biology

Patient-derived SARS-CoV-2 mutations impact viral replication dynamics and infectivity in vitro and with clinical implications in vivo

Hangping Yao et al.

CELL DISCOVERY (2020)

添加到收藏夹

Article Medicine, General & Internal

Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology

Rossana Bussani et al.

EBIOMEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Proteins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19

Francis K. Yoshimoto

PROTEIN JOURNAL (2020)

添加到收藏夹

Article Respiratory System

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

Konstantinos Evangelou et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

添加到收藏夹

Letter Immunology

Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient

Jing Sun et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Article Immunology

Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells

Sunhee Lee et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Review Virology

Coronavirus envelope protein: current knowledge

Dewald Schoeman et al.

VIROLOGY JOURNAL (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

Robert N. Kirchdoerfer et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Infectious Diseases

Replicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection

Wan Beom Park et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Virus-Receptor Interactions: The Key to Cellular Invasion

Melissa S. Maginnis

JOURNAL OF MOLECULAR BIOLOGY (2018)

添加到收藏夹

Article Virology

Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells

Jean Kaoru Millet et al.

VIROLOGY (2018)

添加到收藏夹

Article Immunology

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and type II IFN Responses

Agata Michalska et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Virology

Inhibition of Stress Granule Formation by Middle East Respiratory Syndrome Coronavirus 4a Accessory Protein Facilitates Viral Translation, Leading to Efficient Virus Replication

Keisuke Nakagawa et al.

JOURNAL OF VIROLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Transcriptional and chromatin regulation in interferon and innate antiviral gene expression

Nancy Au-Yeung et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2018)

添加到收藏夹

Article Virology

Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History

Ying Tao et al.

JOURNAL OF VIROLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular Evolution of Human Coronavirus Genomes

Diego Forni et al.

TRENDS IN MICROBIOLOGY (2017)

添加到收藏夹

Article Microbiology

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

Diede Oudshoorn et al.

MBIO (2017)

添加到收藏夹

Article Virology

Extensive Positive Selection Drives the Evolution of Nonstructural Proteins in Lineage C Betacoronaviruses

Diego Forni et al.

JOURNAL OF VIROLOGY (2016)

添加到收藏夹

Letter Medicine, General & Internal

Viral Load Kinetics of MERS Coronavirus Infection

Myoung-don Oh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

添加到收藏夹

Article Microbiology

High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling

Nerea Irigoyen et al.

PLOS PATHOGENS (2016)

添加到收藏夹

Review Virology

Structure, Function, and Evolution of Coronavirus Spike Proteins

Fang Li

ANNUAL REVIEW OF VIROLOGY, VOL 3 (2016)

添加到收藏夹

Article Virology

Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference

Justin K. Taylor et al.

JOURNAL OF VIROLOGY (2015)

添加到收藏夹

Article Virology

High Secretion of Interferons by Human Plasmacytoid Dendritic Cells upon Recognition of Middle East Respiratory Syndrome Coronavirus

Vivian A. Scheuplein et al.

JOURNAL OF VIROLOGY (2015)

添加到收藏夹

Article Virology

Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme

Xingchuan Huang et al.

JOURNAL OF VIROLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets

Yang Yang et al.

SCIENTIFIC REPORTS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

Mickael Bouvet et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

Xingxing Yang et al.

JOURNAL OF GENERAL VIROLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

Jean Kaoru Millet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Multidisciplinary Sciences

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Lorenzo Subissi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus

Yang Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Virology

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein

Shuai Xia et al.

VIRUS RESEARCH (2014)

添加到收藏夹

Article Microbiology

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis

Jose L. Nieto-Torres et al.

PLOS PATHOGENS (2014)

添加到收藏夹

Article Microbiology

Theory and Empiricism in Virulence Evolution

James J. Bull et al.

PLOS PATHOGENS (2014)

添加到收藏夹

Review Microbiology

Coronavirus infection, ER stress, apoptosis and innate immunity

To S. Fung et al.

FRONTIERS IN MICROBIOLOGY (2014)

添加到收藏夹

Article Virology

Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2

Kazuya Shirato et al.

JOURNAL OF VIROLOGY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26

Guangwen Lu et al.

NATURE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

V. Stalin Raj et al.

NATURE (2013)

添加到收藏夹

Article Virology

Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production

Ewan P. Plant et al.

VIRUSES-BASEL (2013)

添加到收藏夹

Article Microbiology

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles

Megan M. Angelini et al.

MBIO (2013)

添加到收藏夹

Article Microbiology

Efficient Replication of the Novel Human Betacoronavirus EMC on Primary Human Epithelium Highlights Its Zoonotic Potential

Eveline Kindler et al.

MBIO (2013)

添加到收藏夹

Article Virology

Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates

Dae-Gyun Ahn et al.

ARCHIVES OF VIROLOGY (2012)

添加到收藏夹

Article Virology

Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry

Miyuki Kawase et al.

JOURNAL OF VIROLOGY (2012)

添加到收藏夹

Article Medicine, General & Internal

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

Ali Moh Zaki et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity

Koji Onomoto et al.

PLOS ONE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

RNA 3′-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

Mickael Bouvet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

添加到收藏夹

Review Virology

Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein

Sandrine Belouzard et al.

VIRUSES-BASEL (2012)

添加到收藏夹

Article Microbiology

Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies

Juan Reguera et al.

PLOS PATHOGENS (2012)

添加到收藏夹

Article Virology

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

Ana Shulla et al.

JOURNAL OF VIROLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

Masato Akutsu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

添加到收藏夹

Article Microbiology

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and Apoptosis

Marta L. DeDiego et al.

PLOS PATHOGENS (2011)

添加到收藏夹

Article Virology

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

Shutoku Matsuyama et al.

JOURNAL OF VIROLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent

Aartjan J. W. te Velthuis et al.

NUCLEIC ACIDS RESEARCH (2010)

添加到收藏夹

Article Microbiology

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

Lance D. Eckerle et al.

PLOS PATHOGENS (2010)

添加到收藏夹

Article Virology

Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF-κB Signaling

Matthew Frieman et al.

JOURNAL OF VIROLOGY (2009)

添加到收藏夹

Review Microbiology

Coronaviruses post-SARS: update on replication and pathogenesis

Stanley Perlman et al.

NATURE REVIEWS MICROBIOLOGY (2009)

添加到收藏夹

Article Multidisciplinary Sciences

The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor

Rinki Minakshi et al.

PLOS ONE (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

Yu Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

添加到收藏夹

Article Multidisciplinary Sciences

Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

Kailang Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

添加到收藏夹

Article Virology

The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu

Amy J. Andrew et al.

RETROVIROLOGY (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

The role of programmed-1 ribosomal frameshifting in coronavirus propagation

Ewan P. Plant et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2008)

添加到收藏夹

Article Virology

Persistent replication of severe acute respiratory syndrome coronavirus in human tubular kidney cells selects for adaptive mutations in the membrane protein

Filippo Pacciarini et al.

JOURNAL OF VIROLOGY (2008)

添加到收藏夹

Article Virology

Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells

Krishna Narayananj et al.

JOURNAL OF VIROLOGY (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus

Santhana G. Devaraj et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

添加到收藏夹

Article Virology

High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants

Lance D. Eckerle et al.

JOURNAL OF VIROLOGY (2007)

添加到收藏夹

Article Hematology

Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon

Luisa Cervantes-Barragan et al.

BLOOD (2007)

添加到收藏夹

Article Multidisciplinary Sciences

Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation

Wataru Kamitani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mechanisms of establishment of persistent SARS-CoV-infected cells

Tetsuya Mizutani et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

添加到收藏夹

Review Virology

Nidovirales:: Evolving the largest RNA virus genome

AE Gorbalenya et al.

VIRUS RESEARCH (2006)

添加到收藏夹

Article Multidisciplinary Sciences

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

G Simmons et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

添加到收藏夹

Article Biotechnology & Applied Microbiology

The 3a protein of severe acute respiratory syndrome-associated coronavirus induces apoptosis in Vero E6 cells

PTW Law et al.

JOURNAL OF GENERAL VIROLOGY (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal

EP Plant et al.

PLOS BIOLOGY (2005)

添加到收藏夹

Article Multidisciplinary Sciences

Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry

H Hofmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2

WH Li et al.

EMBO JOURNAL (2005)

添加到收藏夹

Article Infectious Diseases

Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase

D Xu et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2005)

添加到收藏夹

Article Virology

Persistent infection of SARS coronavirus in colonic cells in vitro

PKS Chan et al.

JOURNAL OF MEDICAL VIROLOGY (2004)

添加到收藏夹

Article Immunology

Epidemiologic clues to SARS origin in China

RH Xu et al.

EMERGING INFECTIOUS DISEASES (2004)

添加到收藏夹

Article Immunology

Long-term SARS coronavirus excretion from patient cohort, China

W Liu et al.

EMERGING INFECTIOUS DISEASES (2004)

添加到收藏夹

Article Virology

Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E

A Bonavia et al.

JOURNAL OF VIROLOGY (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.