期刊
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
卷 121, 期 -, 页码 207-219出版社
JOURNAL MATER SCI TECHNOL
DOI: 10.1016/j.jmst.2021.12.054
关键词
Dopamine-hyaluronic acid-based cryogels; Antioxidant; Photothermal antibacterial; Wound healing; Hemostasis
资金
- National Natural Science Foundation of China [51973172]
- Natural Science Foundation of Shaanxi Province [2020JC-03, 2019TD-020]
- State Key Laboratory for Mechanical Behavior of Materials
- Fundamental Research Funds for the Central Universities
- Fundamental Research Funds for the World-Class Universities (Disciplines)
- Characteristic Development Guidance Funds for the Central Universities
- Opening Project of Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2019LHM-KFKT008]
This study developed a cryogel dressing with excellent antibacterial properties and water absorption ability. The cryogels demonstrated stable mechanical properties, antioxidant performance, and photothermal antibacterial ability. They showed great potential in preventing wound infections and treating infected wounds.
Cryogel dressings with good absorption ability and photothermal antibacterial properties for preventing wound infections and treating infected wounds have attracted widespread attention. In this work, a series of cryogels with macroporous structure, antioxidant and photothermal properties were prepared based on adipic dihydrazide modified hyaluronic acid (HA-ADH), and dopamine (DA). The antioxidant properties, hemostatic properties, near infrared (NIR) assisted photothermal antibacterial ability provided by polydopamine, recyclable compression mechanical properties, and cytocompatibility were tested. The results demonstrated that the HA-ADH/DA cryogels have stable mechanical properties, great antibacterial properties against E. coli (EC) and methicillin-resistant S. aureus (MRSA). The high swelling ratio due to the high water retention of HA equipped the cryogels with the capability of absorbing exuded blood and excessive tissue fluid in the infected full-thickness skin defect model of mouse. The cryogels demonstrated good cytocompatibility and antioxidant performance through cell tests and 1, 1-diphenyl2-methylbenzohydrazino (DPPH) scavenging efficiency test. The cryogels showed enhanced blood-clotting index (BCI) and better hemostatic ability in the mouse liver trauma model and the rat deep non compressible liver defect model compared with gauze and gelatin sponge. Furthermore, compared with commercial TegadermTM dressing in vivo , the HA-ADH/DA cryogels could greatly promote infected skin wound healing in a full-thickness infected skin defect wound model. In summary, the macroporous HAADH/DA cryogels with good antioxidant, high swelling ratio, photothermal antibacterial property, and biocompatibility are a promising hemostatic material and wound healing dressing. (C) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
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