期刊
ADVANCED FUNCTIONAL MATERIALS
卷 25, 期 9, 页码 1451-1462出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201402338
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资金
- National Natural Science Foundation for Distinguished Young Scholars [81225011]
- State Key Program of National Natural Science of China [81230036]
- National Natural Science Foundation of China [81371580, 81201186]
- China Postdoctoral Science Foundation [2013M530014]
Polypyrrole nanoparticles conjugating gadolinium chelates were successfully fabricated for dual-modal magnetic resonance imaging (MRI) and photoacoustic imaging guided photothermal therapy of cancer, from a mixture of pyrrole and pyrrole-1-propanoic acid through a facile one-step aqueous dispersion polymerization, followed by covalent attachment of gadolinium chelate, using polyethylene glycol as a linker. The obtained PEGylated polypyrrole nanoparticles conjugating gadolinium chelates (Gd-PEG-PPy NPs), sized around around 70 nm, exhibited a high T-1 relaxivity coefficient of 10.61 L mM(-1) s(-1), more than twice as high as that of the relating free Gd3+ complex (4.2 L mM(-1) s(-1)). After 24 h intravenous injection of Gd-PEG-PPy NPs, the tumor sites exhibited obvious enhancement in both T-1-weighted MRI intensity and photoacoustic signal compared with that before injection, indicating the efficient accumulation of Gd-PEG-PPy NPs due to the introduction of the PEG layer onto the particle surface. In addition, tumor growth could be effectively inhibited after treatment with Gd-PEG-PPy NPs in combination with near-infrared laser irradiation. The passive targeting and high MRI/photoacoustic contrast capability of Gd-PEG-PPy NPs are quite favorable for precise cancer diagnosing and locating the tumor site to guide the external laser irradiation for photothermal ablation of tumors without damaging the surrounding healthy tissues. Therefore, Gd-PEG-PPy NPs may assist in better monitoring the therapeutic process, and contribute to developing more effective personalized medicine,showing great potential for cancer diagnosis and therapy.
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