Low vitamin D is a marker for poor health and increased risk for disease: But causality is still unclear in most cases

Article Medicine, General & Internal

Real-world evidence for the effectiveness of vitamin D supplementation in reduction of total and cause-specific mortality

Sha Sha et al.

Summary: A study on the UK Biobank cohort found that the use of vitamin D supplements is associated with lower all-cause mortality and reduced mortality from cancer, cardiovascular disease, and respiratory disease.

JOURNAL OF INTERNAL MEDICINE (2023)

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Article Immunology

Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells

Daniel Chauss et al.

Summary: Research suggests that Vitamin D plays a crucial role in regulating the transcriptional response of T cells, leading to the transition from pro-inflammatory to suppressive cells. In patients with severe COVID-19, disruptions in Vitamin D signaling may be responsible for dysregulation of the immune system, resulting in increased inflammation.

NATURE IMMUNOLOGY (2022)

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Review Medicine, General & Internal

Vitamin D, respiratory infections, and chronic disease: Review of meta-analyses and randomized clinical trials

Davaasambuu Ganmaa et al.

Summary: Current evidence from RCTs and meta-analyses of RCTs is inconsistent regarding the effects of vitamin D supplementation on respiratory infections and chronic diseases. Individuals most likely to benefit are those with baseline VDD or with selected high-risk conditions.

JOURNAL OF INTERNAL MEDICINE (2022)

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Article Neurosciences

Role of Neural Stem Cells and Vitamin D Receptor (VDR)-Mediated Cellular Signaling in the Mitigation of Neurological Diseases

Chinnappa A. Uthaiah et al.

Summary: Specific stem cell-based therapies and supplementing vitamin D have shown efficacy in enhancing neurogenesis and treating neurological disorders. Further research is needed to explore the implications of vitamin D receptor mutations on disease pathophysiology and response to drug treatment.

MOLECULAR NEUROBIOLOGY (2022)

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Review Nutrition & Dietetics

Vitamin D and Its Target Genes

Carsten Carlberg

Summary: The vitamin D metabolite 1 alpha,25-dihydroxyvitamin D-3 acts as a ligand for the transcription factor vitamin D receptor (VDR), and regulates the expression of target genes through chromatin changes. VDR binds to genomic DNA and interacts with partner proteins.

NUTRIENTS (2022)

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Review Nutrition & Dietetics

Predictive value of 25-hydroxyvitamin D level in patients with coronary artery disease: A meta-analysis

Hailing Zhang et al.

Summary: This meta-analysis suggests that low blood 25-hydroxyvitamin D level may be an independent predictor of cardiovascular or all-cause mortality and major adverse cardiovascular events in patients with coronary artery disease (CAD). Baseline 25-hydroxyvitamin D level may provide useful information for CAD patients.

FRONTIERS IN NUTRITION (2022)

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Review Nutrition & Dietetics

Comparing the Evidence from Observational Studies and Randomized Controlled Trials for Nonskeletal Health Effects of Vitamin D

William B. Grant et al.

Summary: Observational studies and randomized controlled trials (RCTs) show discrepancies in the effects of vitamin D on health outcomes. Careful interpretation is needed due to biases and confounding in observational studies, as well as limitations in RCT designs. Before further RCTs are considered, Hill's criteria and results from observational studies can be used to examine the relevance of vitamin D for health outcomes.

NUTRIENTS (2022)

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Article Endocrinology & Metabolism

Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

David A. Jolliffe et al.

Summary: Vitamin D supplementation was found to be safe and reduce the risk of acute respiratory infections, especially when administered in daily doses of 400-1000 IU for up to 12 months and to participants aged 1.00-15.99 years. However, the relevance of these findings to COVID-19 is uncertain and further investigation is needed.

LANCET DIABETES & ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism

Vitamin D and Immune Regulation: Antibacterial, Antiviral, Anti-Inflammatory

Emma L. Bishop et al.

Summary: Vitamin D plays a crucial role in regulating immune function by modulating immune cell activity, stimulating antimicrobial protein expression, and reducing intracellular iron levels to combat infections. Additionally, it can suppress inflammatory T cells and induce immunomodulatory responses.

JBMR PLUS (2021)

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Article Medicine, General & Internal