Sub-pixel energy-weighting techniques for metallic contaminant highlighting in a pharmaceutical hard capsule using a Timepix3 CdZnTe hybrid pixel detector

The presented work describes the capabilities of a state-of-the-art spectroscopic photon-counting hybrid pixel detector for use in non-destructive testing, as a contaminant detector with potential uses in the food and pharmaceutical industries. A pharmaceutical hard capsule containing vitamin powder, contaminated with Steel (ST) and Tungsten (W) was prepared under controlled conditions. Both contaminants are distinguished from the powder by combining sub-pixel imaging with spectroscopic imaging analysis, made possible by the use of a 2 mm CdZnTe sensor coupled to a Timepix3 ASIC, operated in Time-over-Threshold and Time-of-Arrival mode. The subpixelization technique achieves a spatial resolution of 18.3 mu m, with a maximum photon flux of 2.5 x 10(6 )photons/s. cm(2). For the spectral analysis technique implemented, each energy bin image is energy-weighted, with weights optimally defined by considering the bin contrast and noise behavior, and combined to form an integrated-spectrum enhanced image with increased contaminant visibility. Contrast-to-Noise Ratio (CNR) for each contaminant type was used for performance assessment of the approach. A CNR increase of 106% above the reference unweighted-spectrum image was achieved for the ST contaminant, while the denser W contaminant showed a CNR increase of 80%. This means that the presented spectroscopic imaging technique is feasible for implementation in material visibility enhancement.

Automated summary

This work presents the capabilities of a state-of-the-art spectroscopic photon-counting hybrid pixel detector for non-destructive testing, particularly for contaminant detection in the food and pharmaceutical industries. By combining sub-pixel imaging with spectroscopic imaging analysis, different substances can be distinguished and contaminant visibility can be enhanced. The results demonstrate the feasibility of this technique for material visibility enhancement.