期刊
JOURNAL OF INFECTIOUS DISEASES
卷 227, 期 9, 页码 1088-1096出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiac428
关键词
human immunodeficiency virus; HIV; HIV-2; HPV; clearance; human papillomavirus; women
In Senegalese women, HIV-positive women had a lower likelihood of clearing incident HPV infections compared to HIV-negative women, while HIV-2-infected or dually infected women were more likely to clear incident HPV infections than HIV-1-infected women.
In Senegalese women, incident HPV infections in HIV-positive women were less likely to clear than those in HIV-negative women and HIV-2-infected or dually infected women were more likely to clear incident HPV infections than HIV-1-infected women. Background Persistent infection with high-risk human papillomavirus (HPV) is associated with development of invasive cervical cancer. Methods Longitudinal data was collected from 174 Senegalese women. We employed marginal Cox proportional hazards models to examine the effect of human immunodeficiency virus (HIV) status (HIV positive vs HIV negative) and HIV type (HIV-1 vs HIV-2 vs dual HIV-1/HIV-2) on clearance of type-specific HPV infection. Analyses were stratified by incident versus prevalent HPV infection. Results Incident HPV infections in HIV-positive women were less likely to clear than those in HIV-negative women (adjusted hazard ratio [HR] = 0.60; 95% confidence interval [CI], .38-.94). Among HIV-positive women, HIV-2-infected women and HIV-1/2 dually infected women were more likely to clear HPV incident infections than HIV-1-infected women (HR = 1.66; 95% CI, .95-2.92 and HR = 2.17; 95% CI, 1.12-4.22, respectively). Incident HPV infections in HIV-positive women with CD4 cell count <= 500 cells/mu L were less likely to clear than those in HIV-positive women with CD4 cell count >500 cells/mu L (HR = 0.65; 95% CI, .42-1.01). No significant associations were observed for prevalent HPV infections. Conclusions HIV infection reduced the likelihood of clearance of incident HPV infection. Furthermore, among HIV-positive women, low CD4 cell count and dual HIV infection were each associated with reduced likelihood of clearance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据