The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy

Correction Chemistry, Multidisciplinary

Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle (vol 43, pg 194, 2022)

Li-wen Ren et al.

ACTA PHARMACOLOGICA SINICA (2023)

Article Oncology

miR-142a-3p Enhances FlaA N/C Protection Against Radiation-Mediated Intestinal Injury by Modulating the IRAK1/NF-kB Signaling Pathway

Teng Liu et al.

Summary: In this study, it was found that recombinant protein FlaA N/C inhibits radiation-induced pyroptosis in intestinal cells by regulating miR-142a-3p and the IRAK1/NF-kB signaling pathway.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

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Review Pharmacology & Pharmacy

Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers

Meiyan Li et al.

Summary: This article reviews the anti-pancreatic cancer effects of natural products derived from herbal medicines via inducing apoptosis and summarizes the related potential signal pathways, providing a foundation for the research and development of new natural products against pancreatic cancer.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Oncology

Progress in the Treatment of HIV-Associated Lymphoma When Combined With the Antiretroviral Therapies

Chaoyu Wang et al.

Summary: With the widespread use of cART, the life expectancy of HIV-infected individuals has greatly improved, but HIV infection and HIV-associated cancers remain the most common causes of death in this population. AIDS-related lymphoma is the most common HIV-associated cancer, with diffuse large B-cell lymphoma and Burkitt's lymphoma being the most common subtypes.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma

Yang Gao et al.

Summary: YKL-5-124, a novel covalent inhibitor with greater selectivity for CDK7 in neuroblastoma cells, shows synergistic cytotoxicity with BRD4 inhibitor JQ1 and improves the therapeutic efficacy of JQ1 in neuroblastoma treatment.

FRONTIERS IN ONCOLOGY (2022)

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Review Oncology

Neoadjuvant Treatment for Resectable and Borderline Resectable Pancreatic Cancer: Chemotherapy or Chemoradiotherapy?

Eva Versteijne et al.

Summary: There is a global shift towards a neoadjuvant approach for patients with resectable or borderline resectable pancreatic cancer. Randomized studies show that neoadjuvant chemotherapy or chemoradiotherapy improves overall survival. However, more effective chemotherapy regimens, such as FOLFIRINOX and Gemcitabine/Nab-paclitaxel, should be investigated in combination with radiotherapy to further improve outcomes.

FRONTIERS IN ONCOLOGY (2022)

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Review Cell Biology

Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis

Lin Lin et al.

Summary: Atherosclerosis is a chronic inflammatory disorder characterized by plaque buildup in arteries, with vascular cell injury playing a key role. Dysregulation of autophagy, pyroptosis, and ferroptosis are closely related to atherosclerosis development and plaque stability, highlighting potential pharmacological strategies for addressing atherogenesis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Oncology

Alternative RNA splicing defects in pediatric cancers: new insights in tumorigenesis and potential therapeutic vulnerabilities

A. S. Venkataramany et al.

Summary: Alternative splicing plays a critical role in the formation and growth of pediatric cancers. This review highlights the various splice variants and affected genes in different types of cancers. Understanding the mechanisms of disease-inducing splicing events can contribute to the development of novel therapeutics.

ANNALS OF ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

The role of m6A modification in pediatric cancer

Yongping Chen et al.

Summary: With the development of RNA modification research, the significance of N6-methyladenosine (m6A) in tumors cannot be overlooked. m6A plays a role in promoting tumor stem cell self-renewal and tumor cell proliferation, affecting post-transcriptional gene expression and altering biological function. This study focuses on the involvement of m6A modification in pediatric cancers and summarizes the relationships between m6A factors and various types of pediatric cancers.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2022)

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Article Biochemistry & Molecular Biology

Iridium(III) complexes entrapped in liposomes trigger mitochondria-mediated apoptosis and GSDME-mediated pyroptosis

Huiwen Zhang et al.

Summary: The report studied the synthesis and characterization of a series of iridium (III) complexes as well as their cytotoxicity against cancer cells in vitro, showing that these complexes need to be trapped in liposomes to exhibit higher anticancer activity. Among them, Ir1Lipo showed the most significant inhibitory effect on cancer cell growth.

JOURNAL OF INORGANIC BIOCHEMISTRY (2022)

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Editorial Material Multidisciplinary Sciences

Copper-induced cell death Excess copper causes mitochondrial protein aggregation and triggers a distinct form of cell death

Martha A. Kahison et al.

SCIENCE (2022)

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Article Multidisciplinary Sciences

Copper induces cell death by targeting lipoylated TCA cycle proteins

Peter Tsvetkov et al.

Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.

SCIENCE (2022)

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Review Pharmacology & Pharmacy

Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions

Leilei Fu et al.

Summary: Drug repurposing refers to the use of a drug for treating diseases other than its original indication. Repurposing non-oncology drugs has become an attractive approach in improving cancer therapy, with potential cost and time advantages. This review focuses on summarizing the therapeutic potential of non-oncology drugs in human cancers and discussing their novel targets and signaling pathways.

ACTA PHARMACEUTICA SINICA B (2022)

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Review Oncology

High-Grade Glioma Treatment Response Monitoring Biomarkers: A Position Statement on the Evidence Supporting the Use of Advanced MRI Techniques in the Clinic, and the Latest Bench-to-Bedside Developments. Part 2: Spectroscopy, Chemical Exchange Saturation, Multiparametric Imaging, and Radiomics

Thomas C. Booth et al.

Summary: This study summarized the evidence for the use of advanced MRI techniques as monitoring biomarkers in the clinic and discussed different imaging modalities and methods. The results showed that MRI techniques have great potential in treatment response assessment, but further research and standardization are needed.

FRONTIERS IN ONCOLOGY (2022)

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Review Cell Biology

Activation mechanisms of inflammasomes by bacterial toxins

Weidong Jing et al.

Summary: Inflammasomes are cytosolic innate immune complexes that assemble in mammalian cells in response to microbial components and endogenous danger signals. Bacterial toxins are a major family of inflammasome activators.

CELLULAR MICROBIOLOGY (2021)

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Article Medicine, Research & Experimental

MCC950 attenuates doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis

Lei Zhang et al.

Summary: In this study, MCC950 was found to significantly improve myocardial function, inhibit inflammation and myocardial fibrosis, and attenuate cardiomyocyte pyroptosis in mice treated with DOX. Mechanistically, MCC950 inhibited the cleavage of NLRP3, ASC, Caspase-1, IL-18, IL-1 beta, and GSDMD induced by DOX in vivo. Overall, MCC950 has the potential to attenuate DOX-induced myocardial injury by inhibiting NLRP3-mediated pyroptosis in vivo and in vitro.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Pathology

Diagnostic and Prognostic Significance of Dysregulated Expression of Circular RNAs in Osteosarcoma

Chenghao Zhang et al.

Summary: This meta-analysis revealed that aberrantly expressed circRNAs are closely associated with clinicopathological parameters, diagnostic, and prognostic values in osteosarcoma. Overexpression of oncogenic circRNAs was linked to poor prognosis, while upregulation of tumor-suppressor circRNAs was correlated with better survival outcomes.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2021)

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Article Biochemistry & Molecular Biology

The LPS induced pyroptosis exacerbates BMPR2 signaling deficiency to potentiate SLE-PAH

Yanjiang Xing et al.

Summary: This study identified BMP receptor deficiency and increased proinflammatory factors in SLE-PAH patients, suggesting their combined contribution to PAH development in SLE. Pyroptotic factors were elevated in the lungs of SLE-PH mice, and the BMPR2 signaling upregulator showed anti-pyroptotic effects in SLE-PH mice and PAECs.

FASEB JOURNAL (2021)

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Article Oncology

P4HA1 regulates human colorectal cancer cells through HIF1α-mediated Wnt signaling

Qiang Zhang et al.

Summary: Colorectal cancer (CRC) is commonly associated with high mortality rates and an aberrant Wnt signaling pathway. This study found that increased expression of prolyl 4-hydroxylase subunit alpha 1 (P4HA1) in CRC tissues and cell lines stabilized hypoxia inducible factor-1 alpha (HIF1 alpha), leading to cell proliferation and tumorigenesis. Silencing P4HA1 decreased cell proliferation, cell cycle arrest, tumorsphere formation, and increased susceptibility to chemotherapy, showing the potential of P4HA1 as a biomarker and therapeutic target for CRC.

ONCOLOGY LETTERS (2021)

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Article Biochemistry & Molecular Biology

Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections

Min Zheng et al.

Summary: The study demonstrates that caspase-6 (CASP6) contributes to the activation of the CASP11-NLRP3 inflammasome in response to gram-negative bacterial infections. Further research is needed to fully understand the specific mechanisms involved.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Oncology

Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?

Zhibin Zhang et al.

Summary: The research highlights the role of gasdermin-mediated inflammatory death in promoting antitumor immunity and converting immune cell killing to inflammatory pyroptosis. This may enhance the effectiveness of immunotherapy but also increase therapy-related toxicity, requiring further study to understand its regulation and potential therapeutic applications.

CANCER IMMUNOLOGY RESEARCH (2021)

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Article Pharmacology & Pharmacy

Sesamin promotes apoptosis and pyroptosis via autophagy to enhance antitumour effects on murine T-cell lymphoma

Ziyu Meng et al.

Summary: Sesamin, a lignan compound in plants, has pharmacological effects such as inhibiting tumor cell proliferation and promoting apoptosis and pyroptosis. Through inducing autophagy, sesamin enhances the antitumor effects on murine T-cell lymphoma.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)

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Review Cell Biology

Programmed cell death in spinal cord injury pathogenesis and therapy

Zhongju Shi et al.

Summary: Spinal cord injury (SCI) leads to functional deterioration due to cell death processes, including programmed cell death (PCD) like apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis, and paraptosis. PCD is an active cell death mediated by gene expression events, crucial for eliminating unnecessary and damaged cells and serves as a defense mechanism. Understanding the roles of PCD can enhance our knowledge of pathophysiological processes and improve functional recovery after SCI.

CELL PROLIFERATION (2021)

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Article Multidisciplinary Sciences

Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11

Zilin Li et al.

Summary: This study identified a novel post-translational modification, ADP riboxanation, mediated by the Shigella effector OspC3, which inactivates the LPS sensing pathway of caspase-4 and caspase-11 and prevents pyroptosis. ADP riboxanation modification on Arg314 and Arg310 in caspase-4 and caspase-11 inhibits their activity, leading to evasion of host defense against Shigella infection. This bacterial virulence mechanism highlights the importance of ADP riboxanation in preventing LPS-induced pyroptosis.

NATURE (2021)

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Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Channelling inflammation: gasdermins in physiology and disease

Xing Liu et al.

Summary: Gasdermins have been identified as mediators of inflammatory cell death known as pyroptosis, forming cell membrane pores upon activation to release pro-inflammatory cytokines. They play important roles in autoimmune and inflammatory diseases, infectious diseases, deafness, and cancer, with potential for novel therapeutic avenues.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Virology

Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages

Hannah S. Eisfeld et al.

Summary: It has been found in the study that viral glycoproteins can strongly activate the inflammasome, leading to cell rupture and the release of inflammatory factors. Experimental evidence confirms that viral glycoproteins can act as innate immune triggers, revealing key mechanisms of viral pathogenesis.

VIRUSES-BASEL (2021)

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Article Multidisciplinary Sciences

Strategies to package recombinant Adeno-Associated Virus expressing the N-terminal gasdermin domain for tumor treatment

Yuan Lu et al.

Summary: Researchers have developed two strategies to package recombinant adeno-associated virus expressing GSDM(NT) efficiently into tumor cells, inducing pyroptosis and robust immune responses in preclinical cancer models.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis

Jeannine Diesch et al.

Summary: Azacitidine (AZA) treatment is used for patients with myelodysplasias that cannot undergo bone marrow transplantation; however, AZA treatment is only partially effective. The authors demonstrate synergy of AZA with compounds inhibiting the chromatin regulators CBP and p300, which is mediated by the RNA-dependent functions of AZA affecting protein translation.

NATURE COMMUNICATIONS (2021)

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Editorial Material Immunology

Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm

Jinghe Zhang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Review Pharmacology & Pharmacy

Update and New Insights on Future Cancer Drug Candidates From Plant-Based Alkaloids

Mounir Tilaoui et al.

Summary: Cancer is a complex disease that can develop resistance to conventional drugs, leading to tumor relapse. Plant-based alkaloids have been researched as potential anticancer agents, showing promising results in cancer treatment within the past few years.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Chemistry, Multidisciplinary

Microenvironment-Responsive Prodrug-Induced Pyroptosis Boosts Cancer Immunotherapy

Yao Xiao et al.

Summary: The absence of tumor antigens poses a challenge in ICB therapy, but inducing tumor-specific pyroptosis while reducing injury in normal tissues is urgently needed. A ROS/GSH dual-responsive nano-prodrug called MCPP with high PTX and P18 loading is designed to selectively induce pyroptosis in tumor cells. Chemo-photodynamic therapy and controlled-release PTX synergistically induce pyroptosis, releasing DAMPs and enhancing ICB efficiency, suggesting a smart strategy to trigger pyroptosis and augment ICB efficiency.

ADVANCED SCIENCE (2021)

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Review Immunology

Apoptosis, Autophagy, NETosis, Necroptosis, and Pyroptosis Mediated Programmed Cell Death as Targets for Innovative Therapy in Rheumatoid Arthritis

Jianan Zhao et al.

Summary: Rheumatoid arthritis is a chronic inflammatory joint disease characterized by chronic synovial inflammation and degeneration of bones and joints. Despite the variety of treatment options available, some patients still have a poor prognosis due to the complex mechanism of the disease. Programmed cell death has been identified as one of the essential pathological mechanisms of RA, contributing to its development through dysregulation in various cell types.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

PANoptosis: A New Insight Into Oral Infectious Diseases

Weiyi Jiang et al.

Summary: The dysbiosis of the oral microbiome leads to oral infectious diseases, and the study of cell death pathways has revealed the important role of PANoptosis in infectious diseases, autoimmunity, and cancer.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Genetics & Heredity

A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma

Yiming Zhang et al.

Summary: In this study, a prognostic model based on pyroptosis-related genes was constructed to predict the outcome of osteosarcoma patients. Key genes affecting the prognosis of osteosarcoma patients were identified, forming a signature that independently predicts survival and metastasis risk.

FRONTIERS IN GENETICS (2021)

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Article Oncology

Prognostic Value of a Pyroptosis-Related Long Noncoding RNA Signature Associated with Osteosarcoma Microenvironment

Xinxin Bu et al.

Summary: The research identified potential biomarkers associated with osteosarcoma prognosis and confirmed their effectiveness in predicting patient outcomes. By analyzing RNA data and clinical information, researchers found that high-risk lncRNAs performed well in predicting survival rates for osteosarcoma.

JOURNAL OF ONCOLOGY (2021)

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Review Oncology

MTHFR Polymorphism Is Associated With Severe Methotrexate-Induced Toxicity in Osteosarcoma Treatment

Wenchao Zhang et al.

Summary: The MTHFR rs1801133 polymorphism is significantly associated with severe liver toxicity induced by high-dose MTX treatment in the Asian population, as well as predisposing patients with this polymorphism to MTX-related mucositis.

FRONTIERS IN ONCOLOGY (2021)

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Review Oncology

Pyroptosis: a new paradigm of cell death for fighting against cancer

Yixin Tan et al.

Summary: Pyroptosis is an inflammatory form of cell death with tumor suppressive function and the ability to evoke anti-tumor immune responses. Cancer therapies induce pyroptosis, enhancing anti-tumor immunity, but also leading to side effects on normal cells.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Multidisciplinary Sciences

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao et al.

Summary: The study reveals the mechanism of ferroptosis induced by inhibiting GPX4 in cancer cells, as well as the potential pathways to enhance or inhibit ferroptosis by intervening in relevant metabolic pathways. Therapeutic strategies targeting different levels of GPX4 expression could be a promising new approach for cancer treatment.

NATURE (2021)

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Review Oncology

Early-phenotype CAR-T cells for the treatment of pediatric cancers

D. Meyran et al.

Summary: CAR-T therapy shows promise for treating childhood cancers, especially when maintained in an early phenotypic stage. Early CAR-T cells have shown superior persistence, proliferation, and antitumor effects, particularly relevant for pediatric patients.

ANNALS OF ONCOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

TRIM25 Rescues Against Doxorubicin-Induced Pyroptosis Through Promoting NLRP1 Ubiquitination

Xiaxia Wang et al.

Summary: This study demonstrates that TRIM25 exerts cardioprotective effects by promoting the ubiquitination of NLRP1 in DOX-induced cardiomyocyte pyroptosis, offering a novel therapeutic strategy for DOX-induced cardiotoxicity.

CARDIOVASCULAR TOXICOLOGY (2021)

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Article Oncology

Exosomes derived from hypoxic bone marrow mesenchymal stem cells rescue OGD-induced injury in neural cells by suppressing NLRP3 inflammasome-mediated pyroptosis

Xiuwen Kang et al.

Summary: Exosomes derived from bone marrow mesenchymal stromal cells have been shown to have significant neuroprotective effects against NLRP3 inflammasome-mediated pyroptosis in cerebral ischemic diseases. Hypoxic exosomes demonstrate more pronounced protective effects compared to normoxic exosomes, indicating their potential for clinical use in treating cerebral ischemia and hypoxia injuries.

EXPERIMENTAL CELL RESEARCH (2021)

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Review Oncology

Caspase-8: A key protein of cross-talk signal way in PANoptosis in cancer

Mingxia Jiang et al.

Summary: Caspase-8 is a key player in cancer, involved in multiple programmed cell death modes and closely associated with tumor growth, invasion, therapeutic resistance, etc.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Article Endocrinology & Metabolism

The role of regulated necrosis in endocrine diseases

Wulf Tonnus et al.

Summary: Research on basic cell death has shown that most pathophysiologically significant cell death is necrotic in nature, while regulated necrosis can take different forms such as necroptosis, pyroptosis, and ferroptosis. Necrosis leads to an immune response by releasing damage-associated molecular patterns, and thus the consequences of regulated necrosis in the endocrine environment are specific.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Review Gastroenterology & Hepatology

Cell death in pancreatic cancer: from pathogenesis to therapy

Xin Chen et al.

Summary: Pancreatic cancer is a devastating gastrointestinal cancer with late diagnosis, limited treatment success and poor prognosis, primarily composed of pancreatic ductal adenocarcinoma (PDAC). The occurrence and progression of PDAC are influenced by various factors, and the exact impact of cell death on PDAC is not yet well described.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Medicine, Research & Experimental

BMP-2 alleviates heart failure with type 2 diabetes mellitus and doxorubicin-induced AC16 cell injury by inhibiting NLRP3 inflammasome-mediated pyroptosis

Jia-Mei Zhang et al.

Summary: The study revealed that BMP-2 affects the expression of ANP and BNP in diabetes-associated cardiomyopathy, and exerts cardioprotective effects by reducing NLRP3 inflammasome activation and cell pyroptosis. The results suggest that BMP-2 may serve as a novel therapeutic target for the treatment of diabetic heart conditions.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Review Pharmacology & Pharmacy

Comparison Between Decitabine and Azacitidine for Patients With Acute Myeloid Leukemia and Higher-Risk Myelodysplastic Syndrome: A Systematic Review and Network Meta-Analysis

Jiale Ma et al.

Summary: A systematic review and network meta-analysis compared the efficacy and safety of DAC and AZA in AML and HR-MDS patients. Both DAC and AZA showed better overall response rate and longer overall survival compared to CCR, but DAC demonstrated higher efficacy in achieving complete remission rate compared to AZA.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways

Yaqiu Wang et al.

Summary: Pyroptosis, apoptosis and necroptosis are well-defined programmed cell death pathways, with growing evidence showing extensive crosstalk among them. PANoptosis, regulated by the PANoptosome complex, combines features of pyroptosis, apoptosis, and/or necroptosis. This new concept is critically involved in various diseases and may inform the development of new therapeutics.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemistry & Molecular Biology

Cisplatin Induces Pyroptosis via Activation of MEG3/NLRP3/caspase-1/GSDMD Pathway in Triple-Negative Breast Cancer

Honglin Yan et al.

Summary: The study revealed that cisplatin induces pyroptosis in triple-negative breast cancer cells through activation of the MEG3/NLRP3/caspase-1/GSDMD pathway, leading to its anti-tumor effects. This finding may contribute to the development of new therapeutic strategies for TNBC.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Oncology

Gasdermin E-mediated programmed cell death: An unpaved path to tumor suppression

Yueyuan Wang et al.

Summary: GSDME, an effector of secondary necrosis, has been identified as a tumor suppressor in cancer tissues. It interacts with multiple pathways of cell death, including apoptosis and autophagy, demonstrating potential anti-cancer activity.

JOURNAL OF CANCER (2021)

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Editorial Material Biotechnology & Applied Microbiology

Alkaliptosis: a new weapon for cancer therapy

Jiao Liu et al.

CANCER GENE THERAPY (2020)

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Article Cell Biology

Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo

Qiuyue Ding et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Review Medicine, Research & Experimental

Pyroptosis: A new frontier in cancer

Yuan Fang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Pathology

What's new in bone forming tumours of the skeleton?

Natasja Franceschini et al.

VIRCHOWS ARCHIV (2020)

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Article Oncology

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

Dan A. Erkes et al.

CANCER DISCOVERY (2020)

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Article Immunology

Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

Yuying Liu et al.

SCIENCE IMMUNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

CD147 Expression Is Associated with Tumor Proliferation in Bladder Cancer via GSDMD

Junming Peng et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Review Cell Biology

Emerging landscape of circular RNAs as biomarkers and pivotal regulators in osteosarcoma

Chao Tu et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Multidisciplinary Sciences

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Zhiwei Zhou et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

Kai S. Beckwith et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhibin Zhang et al.

NATURE (2020)

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Article Multidisciplinary Sciences

A bioorthogonal system reveals antitumour immune function of pyroptosis

Qinyang Wang et al.

NATURE (2020)

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Review Oncology

Targeting apoptosis in cancer therapy

Benedito A. Carneiro et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Review Cell Biology

The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression

Chao Tu et al.

CELL PROLIFERATION (2020)

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Review Immunology

The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)

Min Zheng et al.

IMMUNOLOGICAL REVIEWS (2020)

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Review Dermatology

Evaluation of the Use of Capecitabine for the Treatment and Prevention of Actinic Keratoses, Squamous Cell Carcinoma, and Basal Cell Carcinoma: A Systematic Review

David M. Schauder et al.

JAMA DERMATOLOGY (2020)

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Review Oncology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Oncology

Immune checkpoint inhibition for pediatric patients with recurrent/refractory CNS tumors: a single institution experience

Chantel Cacciotti et al.

JOURNAL OF NEURO-ONCOLOGY (2020)

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Review Oncology

Combining Systemic Therapy With Radiation: Head and Neck Cancer Treatments in an Era of Targeted Agents and Immunotherapy

Harish N. Vasudevan et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

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Article Biochemistry & Molecular Biology

CARD8 inflammasome activation triggers pyroptosis in human T cells

Andreas Linder et al.

EMBO JOURNAL (2020)

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Article Multidisciplinary Sciences

Lymph protects metastasizing melanoma cells from ferroptosis

Jessalyn M. Ubellacker et al.

NATURE (2020)

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Editorial Material Cell Biology

PD-L1 controls cancer pyroptosis

Maria Teresa Blasco et al.

NATURE CELL BIOLOGY (2020)

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Article Cell Biology

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

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Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

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Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

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Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells

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APOPTOSIS (2014)

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HKH40A downregulates GRP78/BiP expression in cancer cells

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Magnesium Sulfate Increases Intracellular Magnesium Reducing Inflammatory Cytokine Release in Neonates

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Nivolumab plus Ipilimumab in Advanced Melanoma

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AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer

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Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

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The IκB kinase (IKK) and NF-κB:: key elements of proinflammatory signalling

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