Posttranslational control of lipogenesis in the tumor microenvironment

Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutritional, translation and proliferative demands. Altered lipid metabolism is a marker of tumor progression that is frequently observed in aggressive tumors with poor prognosis. Underlying these abnormal metabolic behaviors are posttranslational modifications (PTMs) of lipid metabolism-related enzymes and other factors that can impact their activity and/or subcellular localization. This review focuses on the roles of these PTMs and specifically on how they permit the re-wiring of cancer lipid metabolism, particularly within the context of the tumor microenvironment.

Automated summary

Metabolic reprogramming of cancer cells in the tumor microenvironment is driven by increased nutritional, translational, and proliferative demands. Altered lipid metabolism, a marker of tumor progression, is frequently observed in aggressive tumors with poor prognosis. These alterations are influenced by posttranslational modifications (PTMs) of lipid metabolism-related enzymes and other factors, which impact their activity and localization. This review focuses on the roles of these PTMs and how they contribute to the rewiring of cancer lipid metabolism, particularly in the tumor microenvironment.