Metabolic features of innate lymphoid cells

Article Gastroenterology & Hepatology

Role of Nutrient-sensing Receptor GPRC6A in Regulating Colonic Group 3 Innate Lymphoid Cells and Inflamed Mucosal Healing

Qihang Hou et al.

Summary: This study found that the nutrient-sensing receptor GPRC6A plays an important role in the function of ILC3s in the gut and identified a novel ILC3 receptor signaling pathway that modulates inflamed mucosal healing.

JOURNAL OF CROHNS & COLITIS (2022)

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Article Immunology

The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut

Ewelina Krzywinska et al.

Summary: In this study, the impact of transcription factor HIF-1 alpha on the phenotype of intestinal NKp46(+) innate lymphoid cells and its effects on gut homeostasis were investigated. The results showed that HIF-1 alpha plays a role in shaping the phenotype of ILCs in the gut, affecting the balance between ILC3s and ILC1s and conferring protection against intestinal damage.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

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Article Multidisciplinary Sciences

Trained ILC3 responses promote intestinal defense

Nicolas Serafini et al.

Summary: Group 3 innate lymphoid cells (ILC3s) in the intestine remain activated for months after exposure to Citrobacter rodentium, leading to enhanced immune response and defense capability. These trained ILC3s undergo metabolic changes and exhibit enhanced proliferative capacity and IL-22 production.

SCIENCE (2022)

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Article Endocrinology & Metabolism

PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation

Di Wu et al.

Summary: In this study, the researchers found that a metabolic reconfiguration in colonic lymphoid tissue inducer (LTi) cells regulated by PD-1 signaling modulates inflammatory states in the gut during anti-PD-1 immunotherapy.

NATURE METABOLISM (2022)

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Review Medicine, Research & Experimental

Targeting memory T cell metabolism to improve immunity

Mauro Corrado et al.

Summary: Vaccination activates specific immune cells to provide protection and promote the development of immune memory against specific pathogens. Recent research has made progress in defining the metabolism of memory T cells and discussed the impact of metabolic abnormalities on infections and vaccine efficacy.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Immunology

Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection

Panagiota Mamareli et al.

Summary: This study demonstrates that targeting the enzyme ACC1 can impair intestinal Th1 and Th17 responses by limiting CD4(+) T-cell expansion and infiltration, suggesting ACC1 as a potential target for modulating T-cell-driven intestinal inflammatory responses. However, inhibition of ACC1 also increases susceptibility to infection with C. rodentium and highlights the importance of ACC1-mediated lipogenesis in ROR gamma t(+) ILC function.

MUCOSAL IMMUNOLOGY (2021)

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Article Endocrinology & Metabolism

The role of peroxisome proliferator-activated receptors (PPAR) in immune responses

Anthos Christofides et al.

Summary: PPARs are fatty acid-activated transcription factors that regulate energy metabolism, with three subtypes identified: PPAR alpha, PPAR gamma, and PPAR beta/delta. They play distinct roles in oxidative and adipose tissues, as well as in immune cells, contributing to immune cell differentiation and inflammation.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Article Cell Biology

Coenzyme A fuels T cell anti-tumor immunity

Michael St Paul et al.

Summary: Metabolic programming plays a crucial role in the anti-tumor properties of T cells. By utilizing metabolomics, it was found that pantothenate and its metabolite CoA drive T cell polarization, bioenergetics, and anti-tumor immunity, enhancing the efficacy of anti-tumor therapy. Pre-treatment plasma pantothenic acid levels were positively correlated with the response to anti-PD1 therapy in melanoma patients.

CELL METABOLISM (2021)

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Article Immunology

Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism

J. L. Fachi et al.

Summary: The study shows that a hypoxic environment increases proliferation and activation of intestinal ILC3, a response regulated by HIF-1 alpha. This activation relies on a HIF-1 alpha-dependent transcriptional program and is important for ILC3 functions in both steady state and infectious conditions.

MUCOSAL IMMUNOLOGY (2021)

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Article Immunology

RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus

Ana C. F. Ferreira et al.

Summary: ILC2 cells can develop in the embryonic thymus from shared T cell precursors before the emergence of double-positive T cells, and migrate to mucosal tissues. The expression of ROR alpha in the thymus promotes ILC2 development while repressing T cell development. Notch signaling, BCL11B, and ROR alpha play critical roles in the co-development of T cells and ILC2 cells in the thymus.

NATURE IMMUNOLOGY (2021)

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Review Cell Biology

Manipulating the Metabolism to Improve the Efficacy of CAR T-Cell Immunotherapy

Marsha Pellegrino et al.

Summary: The adoptive transfer of CAR-expressing T cells has shown unprecedented success in treating B-cell malignancies, but its efficacy in other types of cancers is still limited. The metabolic fitness of CAR T cells plays a crucial role in their ability to target and function within solid tumors, with both tumor and T cell metabolism impacting the immune response significantly.

CELLS (2021)

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Article Immunology

ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice

Takahiro Nakajima et al.

Summary: The study reveals that pathogenic CD4(+) T cells in the lungs and skin exhibit high levels of ACC1. ACC1 regulates the inflammatory function of pathogenic CD4(+) T cell population to promote type 2 inflammation in the lungs and skin.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Hematology

Polarized mitochondria as guardians of NK cell fitness

Laura Surace et al.

Summary: This study revealed that different subsets of NK cells exhibit varied responses in mitochondrial dynamics upon activation, highlighting the central role of mitochondrial polarization in regulating NK cell function.

BLOOD ADVANCES (2021)

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Review Medicine, Research & Experimental

Optimization of metabolism to improve efficacy during CAR-T cell manufacturing

Meng Zhang et al.

Summary: CAR-T cell therapy has shown significant efficacy in treating hematological malignancies, but faces challenges in solid tumor therapy. Researchers have been focusing on improving the metabolic adaptability and antitumor activity of CAR-T cells, leading to some breakthroughs in recent years.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Immunology

Dichotomous metabolic networks govern human ILC2 proliferation and function

Laura Surace et al.

Summary: ILC2 metabolism in humans is not well studied, but research shows that ILC2 relies on different metabolic pathways to sustain proliferation and function, with glycolysis and amino acids playing important roles post-activation for IL-13 production.

NATURE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Skin-resident innate lymphoid cells converge on a pathogenic effector state

Piotr Bielecki et al.

Summary: This study reveals that induction of psoriasis in mice by IL-23 or imiquimod leads to a reconfiguration of skin ILCs towards a pathogenic ILC3-like state. Skin ILCs exhibit a range and flexibility in their responses, indicating that immune activities primed in healthy tissues dynamically adapt to provocations and, left unchecked, drive pathological remodelling.

NATURE (2021)

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Article Cell Biology

Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment

Sophie M. Poznanski et al.

Summary: NK cells play a central role in anti-tumor immunity, but their dysfunction in the tumor microenvironment is a major barrier for cancer immunotherapies. Research showed that human NK cell dysfunction in the tumor microenvironment is caused by suppression of glucose metabolism, and activating the antioxidant pathway can restore NK cell function and enhance anti-tumor activity. Additionally, expanded NK cells with metabolic flexibility not only sustained metabolic fitness but also improved tumor killing in response to nutrient deprivation, showing the potential for exploiting metabolic flexibility in cancer immunotherapy.

CELL METABOLISM (2021)

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Review Immunology

Tissue-Specific Molecular Markers and Heterogeneity in Type 2 Innate Lymphoid Cells

Enrique Olguin-Martinez et al.

Summary: Innate lymphoid cells (ILCs) are a newly described subgroup of lymphoid cells, showing heterogeneity similar to different groups of T cells. Different types of ILCs have distinct functions in different tissues and express different markers. Among them, ILC2s respond to stimuli like parasites and regulate immune responses.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+T cells

Ilkka Liikanen et al.

Summary: Adoptive T cell therapies show great promise in cancer treatment, but face challenges. Promoting CD8(+) T cell adaptation to tissue residency can enhance tumor-infiltrating lymphocyte function. Research has found that deleting the HIF negative regulator VHL can induce T cell differentiation into Trm-like TILs, increasing anti-tumor activity.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Multidisciplinary Sciences

PPAR? drives IL-33-dependent ILC2 pro-tumoral functions

Giuseppe Ercolano et al.

Summary: The expression of PPARγ in ILC2s sustains type-2 cytokines secretion and supports their pro-tumorigenic role in preclinical cancer models. Pharmacologic inhibition or genetic deletion of PPARγ in ILC2s significantly impair IL-33-induced Type-2 cytokine production and mitochondrial fitness.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Metabolic changes of Interleukin-12/15/18-stimulated human NK cells

Inigo Terren et al.

Summary: NK cells acquire memory-like properties following stimulation with IL-12, IL-15 and IL-18, and these cytokine-induced memory-like NK cells have shown promising potential in cancer immunotherapy. NK cells modulate their metabolism in response to cytokine-stimulation, with a link between metabolism and cellular functions.

SCIENTIFIC REPORTS (2021)

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Review Pharmacology & Pharmacy

Natural killer (NK) cell-based immunotherapies and the many faces of NK cell memory: A look into how nanoparticles enhance NK cell activity

Idoia Mikelez-Alonso et al.

Summary: NK cells are lymphocytes with potent antitumor and antiviral functions, exhibiting memory-like responses. Various NK cell-based immunotherapies have been developed, with nanotechnology considered as an attractive option to enhance NK cell effector functions.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Biochemistry & Molecular Biology

Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer

Jeremy Goc et al.

Summary: Research shows that ILC3s play a protective role in cancer, and alterations in CRC may lead to dysfunctional adaptive immunity, tumor progression, and immunotherapy resistance.

CELL (2021)

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Article Multidisciplinary Sciences

An engineered IL-2 partial agonist promotes CD8+ T cell stemness

Fei Mo et al.

Summary: Adoptive transfer of antigen-specific T cells is a significant advancement in cancer immunotherapy, and maintaining a stem-cell-like state before transfer is beneficial for therapeutic efficacy.

NATURE (2021)

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Article Immunology

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot et al.

Summary: ILC2s play a critical role in melanoma immunity by producing cytokines that enhance antitumor responses. High infiltration of ILC2s in melanoma is associated with good clinical prognosis, but their antitumor functions may be restricted by programmed cell death protein-1.

NATURE IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis

Laura Ducimetiere et al.

Summary: This study found that innate lymphocyte subpopulations cNKs and trILC1s play nonredundant roles in controlling liver metastasis seeding and outgrowth, respectively, and may contribute to developing therapies involving hepatic innate cells.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Immunology

Metabolic barriers to cancer immunotherapy

Kristin DePeaux et al.

Summary: The tumour microenvironment creates barriers that suppress immune responses, including physical barriers, recruitment of suppressive immune cells, and upregulation of inhibitory ligands on tumour cells. Therapies targeting metabolic restrictions in the tumour microenvironment show promise for combination therapies against various types of cancer.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Cell Biology

Targeting immunometabolism as an anti-inflammatory strategy

Eva M. Palsson-McDermott et al.

CELL RESEARCH (2020)

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Article Multidisciplinary Sciences

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

John Alec Moral et al.

NATURE (2020)

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Article Immunology

Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity

Jing Ni et al.

IMMUNITY (2020)

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Correction Immunology

Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation (vol 52, pg 620, 2020)

Fotios Karagiannis et al.

IMMUNITY (2020)

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Review Multidisciplinary Sciences

A Potential Role for Epigenetically Mediated Trained Immunity in Food Allergy

Samira Imran et al.

ISCIENCE (2020)

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Article Hematology

Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment

Takumi Kobayashi et al.

BLOOD (2020)

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Article Multidisciplinary Sciences

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

Doumet Georges Helou et al.

NATURE COMMUNICATIONS (2020)

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Review Immunology

Metabolism of Natural Killer Cells and Other Innate Lymphoid Cells

Jingjing Cong

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways

Yi-Na Liu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Immunology

Trained immunity as a novel approach against COVID-19 with a focus on Bacillus Calmette-Guerin vaccine: mechanisms, challenges and perspectives

Yahya Sohrabi et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2020)

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Review Immunology

Metabolic coordination of T cell quiescence and activation

Nicole M. Chapman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Natural killer cell metabolism

Takumi Kobayashi et al.

MOLECULAR IMMUNOLOGY (2019)

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Review Immunology

Induction of innate immune memory: the role of cellular metabolism

Jorge Dominguez-Andres et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

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Review Immunology

Innate lymphoid cells: A potential link between microbiota and immune responses against cancer

Santosh K. Panda et al.

SEMINARS IN IMMUNOLOGY (2019)

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Article Cell Biology

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

Xingzhe Ma et al.

CELL METABOLISM (2019)

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Review Cell Biology

ILC3 function as a double-edged sword in inflammatory bowel diseases

Boning Zeng et al.

CELL DEATH & DISEASE (2019)

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Article Immunology

ILC3s integrate glycolysis and mitochondrial production of reactive oxygen species to fulfill activation demands

BLanda Di Luccia et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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Review Immunology

Metabolic adaptations of tissue-resident immune cells

George Caputa et al.

NATURE IMMUNOLOGY (2019)

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Review Immunology

What Defines NK Cell Functional Fate: Phenotype or Metabolism?

Sophie M. Poznanski et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Meeting Abstract Dermatology

PPARγ regulates IL-9 expression in human TH2 cells by promoting glycolysis

L. von Meyenn et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Review Immunology

The Metabolic Requirements of Th2 Cell Differentiation

Julian M. Stark et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

NK Cell Metabolism and TGFβ - Implications for Immunotherapy

Karen Slattery et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Immunology

Human TH9 cells are a subpopulation of PPAR-γ+ TH2 cells

Claire Micosse et al.

SCIENCE IMMUNOLOGY (2019)

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Review Immunology

Immunometabolism and natural killer cell responses

Katie L. O'Brien et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Immunology

E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor

Qian Li et al.

IMMUNITY (2018)

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Article Immunology

Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism

Vanessa Zaiatz-Bittencourt et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Roisin M. Loftus et al.

NATURE COMMUNICATIONS (2018)

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Review Biochemistry & Molecular Biology

Innate Lymphoid Cells: 10 Years On

Eric Vivier et al.

CELL (2018)

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Review Gastroenterology & Hepatology

Immunometabolism: A novel perspective of liver cancer microenvironment and its influence on tumor progression

Qi Zhang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

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Article Oncology

PPAR-Induced Fatty Acid Oxidation in T Cells Increases the Number of Tumor-Reactive CD8+ T Cells and Facilitates Anti-PD-1 Therapy

Partha S. Chowdhury et al.

CANCER IMMUNOLOGY RESEARCH (2018)

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Article Multidisciplinary Sciences

IRE1 alpha-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

Minkyung Song et al.

NATURE (2018)

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Article Immunology

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

Xavier Michelet et al.

NATURE IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

Experimental evolution of a fungal pathogen into a gut symbiont

Gloria Hoi Wan Tso et al.

SCIENCE (2018)

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Review Immunology

Unraveling the Complex Interplay Between T Cell Metabolism and Function

Ramon I. Klein Geltink et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)

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Article Medicine, Research & Experimental

Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect

Martin Felices et al.

JCI INSIGHT (2018)

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Article Immunology

Cutting Edge: IL-2-Induced Expression of the Amino Acid Transporters SLC1A5 and CD98 Is a Prerequisite for NKG2D-Mediated Activation of Human NK Cells

Helle Jensen et al.

JOURNAL OF IMMUNOLOGY (2017)

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Review Biochemistry & Molecular Biology

Innate Lymphoid Cell Immunometabolism

Timothy E. O'Sullivan et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

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Article Immunology

Srebp-controlled glucose metabolism is essential for NK cell functional responses

Nadine Assmann et al.

NATURE IMMUNOLOGY (2017)

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Article Immunology

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

Victor S. Cortez et al.

NATURE IMMUNOLOGY (2017)

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Article Immunology

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells

Yulong Gao et al.

NATURE IMMUNOLOGY (2017)

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Review Immunology

Metabolic reprograming of anti-tumor immunity

Madhusudhanan Sukumar et al.

CURRENT OPINION IN IMMUNOLOGY (2017)

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Review Biochemistry & Molecular Biology

Metabolic Instruction of Immunity

Michael D. Buck et al.

CELL (2017)

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Correction Biochemistry & Molecular Biology

mTOR Signaling in Growth, Metabolism, and Disease (vol 168, pg 960, 2017)

Robert A. Saxton et al.

CELL (2017)

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Review Endocrinology & Metabolism

Regulation of metabolism by the innate immune system

Denise E. Lackey et al.

NATURE REVIEWS ENDOCRINOLOGY (2016)

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Article Biochemistry & Molecular Biology

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

Meital Gury-BenAri et al.

CELL (2016)

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Article Biochemistry & Molecular Biology

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

David Clever et al.

CELL (2016)

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Article Biochemistry & Molecular Biology

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Roger Geiger et al.

CELL (2016)

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Article Immunology

Allergen-Experienced Group 2 Innate Lymphoid Cells Acquire Memory-like Properties and Enhance Allergic Lung Inflammation

Itziar Martinez-Gonzalez et al.

IMMUNITY (2016)

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Article Immunology

Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection

Christoph Wilhelm et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

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Article Immunology

Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1

Celeste C. Goh et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Immunology

Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells

Sinead E. Keating et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

Wei Yang et al.

NATURE (2016)

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Article Multidisciplinary Sciences

Ionic immune suppression within the tumour microenvironment limits T cell effector function

Robert Eil et al.

NATURE (2016)

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Article Immunology

The evolution of innate lymphoid cells

Eric Vivier et al.

NATURE IMMUNOLOGY (2016)

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Article Immunology

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Shih-Chin Cheng et al.

NATURE IMMUNOLOGY (2016)

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Article Immunology

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

Laurel A. Monticelli et al.

NATURE IMMUNOLOGY (2016)

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Article Immunology

IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

Yoichiro Ohne et al.

NATURE IMMUNOLOGY (2016)

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Article Immunology

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

Suzanne M. Bal et al.

NATURE IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

Sebastien Viel et al.

SCIENCE SIGNALING (2016)

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Article Biochemistry & Molecular Biology

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

Sebastien Viel et al.

SCIENCE SIGNALING (2016)

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Review Immunology

A guide to immunometabolism for immunologists

Luke A. J. O'Neill et al.

NATURE REVIEWS IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ping-Chih Ho et al.

CELL (2015)

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Article Immunology

Interleukin-12 and-23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

Jochem H. Bernink et al.

IMMUNITY (2015)

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Review Immunology

The Cellular and Molecular Basis of Translational Immunometabolism

Giuseppe Danilo Norata et al.

IMMUNITY (2015)

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Article Immunology

Activation-Specific Metabolic Requirements for NK Cell IFN-γ Production

Molly P. Keppel et al.

JOURNAL OF IMMUNOLOGY (2015)

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Article Multidisciplinary Sciences

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

Nikolaos Patsoukis et al.

NATURE COMMUNICATIONS (2015)

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Article Medicine, Research & Experimental

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

Valerie A. Gerriets et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Article Immunology

IL-25-responsive, lineage-negative KLRG1hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells

Yuefeng Huang et al.

NATURE IMMUNOLOGY (2015)

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Review Immunology

Molecular and cellular insights into T cell exhaustion

E. John Wherry et al.

NATURE REVIEWS IMMUNOLOGY (2015)

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Review Immunology

Metabolic Regulation of Immune Responses

Kirthana Ganeshan et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

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Article Cell Biology

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

Andrew N. Macintyre et al.

CELL METABOLISM (2014)

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Article Immunology

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

Raymond P. Donnelly et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Immunology

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

Alfredo Caro-Maldonado et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Immunology

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

Antoine Marais et al.

NATURE IMMUNOLOGY (2014)

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Article Multidisciplinary Sciences

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity

Shih-Chin Cheng et al.

SCIENCE (2014)

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Article Immunology

The critical role of IL-15-PI3K-mTOR pathway in natural killer cell effector functions

Neethi Nandagopal et al.

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