期刊
JOURNAL OF EUKARYOTIC MICROBIOLOGY
卷 69, 期 6, 页码 -出版社
WILEY
DOI: 10.1111/jeu.12947
关键词
apicoplast; malaria; metabolism; Plasmodium; plastid
类别
资金
- University of Melbourne
This article discusses the roles of a crucial cellular compartment, the apicoplast, in the different stages of the malaria parasite's life cycle, with a focus on two species of Plasmodium.
Malaria parasites are diheteroxenous, requiring two hosts-a vertebrate and a mosquito-to complete their life cycle. Mosquitoes are the definitive host where malaria parasite sex occurs, and vertebrates are the intermediate host, supporting asexual amplification and more significant geographic spread. In this review, we examine the roles of a single malaria parasite compartment, the relict plastid known as the apicoplast, at each life cycle stage. We focus mainly on two malaria parasite species-Plasmodium falciparum and P. berghei-comparing the changing, yet ever crucial, roles of their apicoplasts.
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