☆ 4.7 Article

Betulinic acid prevents liver fibrosis by binding Lck and suppressing Lck in HSC activation and proliferation

JOURNAL OF ETHNOPHARMACOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Pharmacology & Pharmacy

Betulinic acid-nucleoside hybrid prevents acute alcohol -induced liver damage by promoting anti-oxidative stress and autophagy

Li-yun Zheng et al.

Summary: Alcoholic abuse is a major cause of liver diseases globally, with oxidative stress being a critical factor. This study showed that BAN, a betulinic acid and nucleoside hybrid compound with good water solubility, effectively reversed acute alcohol-induced liver damages by reducing serum ALT level and liver oxidative stress. The protective role of BAN was mediated through hepatic FXR activation and the promotion of cellular autophagy.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

添加到收藏夹

Article Pathology

Identification of immune-infiltrating cell-related biomarkers in hepatocellular carcinoma based on gene co-expression network analysis

Yinghui Hou et al.

Summary: Nine hub genes were identified in HCC through RNA sequencing data analysis and immune cell infiltration scoring, with their expression levels positively correlated with CD8(+) T cell infiltration. Some of these genes showed decreased expression in cancer tissues, and low expression of LCK was associated with poor prognosis in patients with HCC.

DIAGNOSTIC PATHOLOGY (2021)

添加到收藏夹

Article Immunology

Tyr192 Regulates Lymphocyte-Specific Tyrosine Kinase Activity in T Cells

Pawel Borowicz et al.

Summary: The study reveals that Lck Tyr(192) regulates Lck pTyr(394) and pTyr(505) activity, playing a crucial role in maintaining a pool of already active Lck in resting T cells. This provides an additional mechanism for fine-tuning Lck and T cell activity.

JOURNAL OF IMMUNOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Effect of betulinic acid administration on TLR-9/NF-κB /IL-18 levels in experimental liver injury

Eda Dokumacioglu et al.

Summary: This study investigated the potential protective effects of betulinic acid on APAP-induced hepatotoxicity in rats. The results showed that betulinic acid significantly decreased the levels of TLR9, IL-18, NF-kappa B, and MDA in liver injury groups. This suggests that betulinic acid may be an effective agent for the prevention and treatment of acute liver diseases.

TURKISH JOURNAL OF MEDICAL SCIENCES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis

Yan Jiang et al.

Summary: In this study, it was found that EZH2 and JMJD3 antagonistically modulate HSCs activation. The therapeutic effects of DZNep as an epigenetic drug in liver fibrosis are associated with the regulation of EZH2 towards direct target genes encoding TGF-I31 pseudoreceptor BAMBI, anti-inflammatory cytokine IL10 and cell cycle regulators CDKN1A, GADD45A and GADD45B, which are also regulated by JMJD3. This study provides new mechanistic insight into the epigenetic modulation of EZH2 and JMJD3 in HSCs biology and hepatic fibrogenesis.

THERANOSTICS (2021)

添加到收藏夹

Article Substance Abuse

Moderate alcohol consumption is not associated with subclinical cardiovascular damage but with hepatic fibrosis in non-alcoholic fatty liver disease

Kazuhiro Kashiwagi et al.

ALCOHOL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Betulinic acid improves nonalcoholic fatty liver disease through YY1/FAS signaling pathway

Qian Mu et al.

FASEB JOURNAL (2020)

添加到收藏夹

Review Immunology

The role of competing mechanisms on Lck regulation

Sabin J. Bozso et al.

IMMUNOLOGIC RESEARCH (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Maurizio Parola et al.

MOLECULAR ASPECTS OF MEDICINE (2019)

添加到收藏夹

Article Oncology

Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1

Li Li et al.

LEUKEMIA RESEARCH (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy

Ursula Bommhardt et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

添加到收藏夹

Article Plant Sciences

New Pharmacological Opportunities for Betulinic Acid

Jose Luis Rios et al.

PLANTA MEDICA (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hypericum japonicum: a Double-Headed Sword to Combat Vector Control and Cancer

Sreedev Puthur et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2018)

添加到收藏夹

Article Plant Sciences

Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum

Yan-Ping Li et al.

JOURNAL OF NATURAL PRODUCTS (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Carvedilol attenuates liver fibrosis by suppressing autophagy and promoting apoptosis in hepatic stellate cells

Dongxiao Meng et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

添加到收藏夹

Review Nanoscience & Nanotechnology

Nanoparticles for the treatment of liver fibrosis

Suchithra Poilil Surendran et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

NLRC5 regulates TGF-β1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis

Tao Xu et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

添加到收藏夹

Article Immunology

Lck Inhibits Heat Shock Protein 65-Mediated Reverse Cholesterol Transport in T Cells

Tiantian Luo et al.

JOURNAL OF IMMUNOLOGY (2016)

添加到收藏夹

Article Gastroenterology & Hepatology

Recent advancement of molecular mechanisms of liver fibrosis

Ekihiro Seki et al.

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES (2015)

添加到收藏夹

Review Chemistry, Medicinal

Betulinic Acid and its Derivatives as Potential Antitumor Agents

Dong-Mei Zhang et al.

MEDICINAL RESEARCH REVIEWS (2015)

添加到收藏夹

Review Radiology, Nuclear Medicine & Medical Imaging

Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging

Dan Li et al.

EJNMMI RESEARCH (2015)

添加到收藏夹

Article Gastroenterology & Hepatology

Nanotechnology applications for the therapy of liver fibrosis

Lydia Giannitrapani et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

The Enhanced Liver Fibrosis (ELF) score: Normal values, influence factors and proposed cut-off values

Ralf Lichtinghagen et al.

JOURNAL OF HEPATOLOGY (2013)

添加到收藏夹

Article Pharmacology & Pharmacy

Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling

Agnieszka Szuster-Ciesielska et al.

TOXICOLOGY (2011)

添加到收藏夹

Review Food Science & Technology

Betulinic acid: A natural product with anticancer activity

Simone Fulda

MOLECULAR NUTRITION & FOOD RESEARCH (2009)

添加到收藏夹

Review Cell Biology

SOCS regulation of the JAK/STAT signalling pathway

Ben A. Croker et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2008)

添加到收藏夹

Article Pharmacology & Pharmacy

Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells

Wojciech Rzeski et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2006)

添加到收藏夹

Article Oncology

A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation

MJ Shi et al.

MOLECULAR CANCER RESEARCH (2006)

添加到收藏夹

Review Gastroenterology & Hepatology

Liver fibrosis - from bench to bedside

SL Friedman

JOURNAL OF HEPATOLOGY (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.