4.7 Review

Phytochemical and pharmacological review of diterpenoids from the genus Euphorbia Linn (2012-2021)

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Euphopanes A-C, three new diterpenoids from Euphorbia pekinensis

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Summary: Three new diterpenoids, euphopanes A-C (1-3), along with five known compounds were isolated from the roots of Euphorbia pekinensis. Compound 1, 2, and 4 showed significant cytotoxicity against human prostate cancer cells C4-2B.

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New diterpenoids from the stems of Euphorbia antiquorum growing in Vietnam

Thanh-Nha Tran et al.

Summary: This study analyzed the stem extracts of Euphorbia antiquorum and identified two new compounds, ent-3 alpha-acetoxy-16 beta,17,18-trihydroxyatisane (1) and ent-3 alpha,14,16 beta,17-tetrahydroxyatisane (2), along with three known compounds. The evaluation of these compounds revealed significant inhibition against alpha-glucosidase, but none showed cytotoxicity activity.

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Bioactive tigliane diterpenoids from the latex of Euphorbia fischeriana

Yan-Yan Deng et al.

Summary: Latex extracted from Euphorbia fischeriana resists the growth of cotton bollworm, Helicoverpa armigera, with the presence of six aliphatic tigliane diterpenoids. Among these compounds, three are newly discovered. Two major compounds demonstrate significant antifeedant activity against H. armigera.

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A new ent-atisane diterpenoid from the aerial parts of Euphorbia antiquorum L.

Thanh-Nha Tran et al.

Summary: A new ent-atisane diterpenoid, ent-3 alpha-acetoxy-1 beta,16 beta,17-trihydroxyatisane (1), was isolated from the aerial parts of Euphorbia antiquorum L, along with four known compounds. The structure of compound 1 was identified through interpretation of spectroscopic data and comparison with literature reports.

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Cytotoxic jatrophane diterpenoids from the aerial parts of Euphorbia helioscopia

Ming Zhou et al.

Summary: A phytochemical study of the aerial parts of Euphorbia helioscopia led to the isolation of three new jatrophane diterpenoids, euphoheliphanes A-C. These compounds exhibited cytotoxic activities against six renal cancer cell lines with IC50 values less than 50 μM.

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Antimicrobial ent-abietane-type diterpenoids from the roots of Euphorbia wallichii

He Li et al.

Summary: Three previously undescribed ent-abietane-type diterpenoids were isolated from the roots of Euphorbia wallichii, and their structures were elucidated by spectroscopic analysis. The isolated compounds exhibited antimicrobial activity against Gram positive bacteria in vitro, with minimum inhibitory concentration values less than 60 μg/ml.

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Three new diterpenoids fromEuphorbia peplus

Yan-Ni Chen et al.

Summary: Three new diterpenoids and four known compounds were isolated from Euphorbia peplus, and their structures were identified through spectroscopic analysis. The cytotoxic activities of the compounds against five human tumor cell lines were evaluated at a concentration of 40 μM, showing no activity. Compound 3 was found to enhance lysosomal biogenesis.

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Jia Meng et al.

Summary: Five new diterpenoids, named euphorfischerins A-E, were isolated from the roots of Euphorbia fischeriana. Euphorfischerin A and euphorfischerin B showed cytotoxicity against human cancer cell lines.

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Diterpenoids from the seeds of Euphorbia lathyris and their effects on microglial nitric oxide production

Quan Zuo et al.

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Jatrophane Diterpenoids from Euphorbia peplus as Multidrug Resistance Modulators with Inhibitory Effects on the ATR-Chk-1 Pathway

Yanlan Yang et al.

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Daphnane-type diterpenoids from Euphorbia fischeriana Steud and their cytotoxic activities

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Eupholides A-H, abietane diterpenoids from the roots of Euphorbia fischeriana, and their bioactivities

Da-Wei Li et al.

Summary: The roots of Euphorbia fischeriana contain 15 diterpenoids that show moderate inhibitory effects on the proliferation of Mycobacterium tuberculosis, with eupholides F-H being the most effective. Additionally, some of these compounds significantly inhibit the lyase activity of human carboxylesterase 2.

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Fischdiabietane A, an Antitumoral Diterpenoid Dimer Featuring an Unprecedented Carbon Skeleton from Euphorbia fischeriana

Jun He et al.

Summary: Fischdiabietane A is a novel asymmetric diterpenoid dimer isolated from Euphorbia fischeriana roots, possessing unique ring systems and structures. It exhibits higher activity against T47D cells compared to cisplatin, inducing apoptosis through caspase-3 activation and poly(ADP-ribose) polymerase degradation.

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Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway

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Diterpenoids from the Seeds of Euphorbia lathyris and their in Vitro Anti-HIV Activity

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A new tetracyclic diterpenoid from the seeds of Euphorbia lathyris

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Euphoresulanes A-M, structurally diverse jatrophane diterpenoids from Euphorbia esula

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Cytotoxic Lathyrane Diterpenoids from the Roots of Euphorbia fischeriana

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Jatrophane Diterpenoids from Euphorbia esula as Inhibitors of RANKL-Induced Osteoclastogenesis

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Ingenane and jatrophane diterpenoids from Euphorbia kansui and their antiproliferative effects

Xian-Hua Meng et al.

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Ye Ye et al.

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Jian-Chun Li et al.

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Diterpenoids from Euphorbia royleana reverse P-glycoprotein-mediated multidrug resistance in cancer cells

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Bioactive Diterpenoids from the Stems of Euphorbia royleana

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Jatrophane Diterpenoids from Euphorbia glomerulans

Aobulikasimu Hasan et al.

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Anti-inflammatory Lathyrane Diterpenoids from Euphorbia lathyris

Cui-Yun Zhang et al.

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Bioactive Diterpenoids from the Stems of Euphorbia antiquorum

Yue Liang et al.

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Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata

Ya-Si Huang et al.

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Macrocyclic Diterpenoids from Euphorbia helioscopia and Their Potential Anti-inflammatory Activity

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NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

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Diterpenoids from Euphorbia neriifolia and Their Related Anti-HIV and Cytotoxic Activity

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Sesquiterpenes and diterpenes from Euphorbia thymifolia

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Euphonoids A - G, cytotoxic diterpenoids from Euphorbia fischeriana

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Six new ent-abietane-type diterpenoids from the stem bark of Euphorbia neriifolia

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Quorumolides A-C, Three Cembranoids from Euphorbia antiquorum

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Pepluanols C-D, Two Diterpenoids with Two Skeletons from Euphorbia peplus

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Phytochemical and cytotoxic studies on the roots of Euphorbia fischeriana

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Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells

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Four New Diterpenoids from the Roots of Euphorbia pekinensis

Rui-Ying Tian et al.

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Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity

Luo-Sheng Wan et al.

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Euphorbesulins A-P, Structurally Diverse Diterpenoids from Euphorbia esula

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Three Minor Diterpenoids with Three Carbon Skeletons from Euphorbia peplus

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Two new myrinsol diterpenoids from Euphorbia dracunculoides Lam

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12,17-Cyclojatrophane and Jatrophane Constituents of Euphorbia welwitschiie

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Anti-HIV terpenoids from Daphne aurantiaca Diels. stems

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A New Lathyrane Diterpenoid from the Whole Plant of Euphorbia altotibetica

Zhan-Xin Zhang et al.

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Daphnane-Type Diterpenoid Glucosides and Further Constituents of Euphorbia pilosa

Xu-Dong Zhang et al.

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Secoeuphoractin, a minor diterpenoid with a new skeleton from Euphorbia micractina

Wen-Dong Xu et al.

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Diterpenes inhibiting NO production from Euphorbia helioscopia

Hongqiang Chen et al.

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Chemical constituents from Euphorbia stracheyi and their biological activities

Da-Song Yang et al.

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Eurifoloids A-R, Structurally Diverse Diterpenoids from Euphorbia neriifolia

Jin-Xin Zhao et al.

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Anti-inflammatory Diterpenoids from the Roots of Euphorbia ebracteolata

Zhi-Guo Liu et al.

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Jatrophanes from Euphorbia squamosa as Potent Inhibitors of Candida albicans Multidrug Transporters

Manpreet Kaur Rawal et al.

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Lathyrane-type diterpenoids from the seeds of Euphorbia lathyris

Jin Lu et al.

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Norlathyrane Diterpenes from the Root of Euphorbia kansuensis

Bei-Bei Zhang et al.

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Four new diterpenoids from the roots of Euphorbia fischeriana

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A new cytotoxic cembrane diterpene from the roots of Euphorbia pekinensis Rupr

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Two New Rosane-Type Diterpenoids from Euphorbia ebracteolata HAYATA

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