期刊
CARBOHYDRATE POLYMERS
卷 123, 期 -, 页码 39-45出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.12.076
关键词
Bioactive glass nanoparticles; Chitosan; Shape memory; Biomimetic; Bioactivity; Hydromechanical cyclic test
资金
- Portuguese Foundation for Science and Technology Foundation (FCT) [PTDC/FIS/115048/2009, SFRH/BD/73174/2010]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/73174/2010] Funding Source: FCT
We propose a combination of chitosan (CHT) with bioactive glass nanoparticles (BG-NPs) in order to produce CHT/BG-NPs scaffolds that combine the shape memory properties of chitosan and the biomin-eralization ability of BG-NPs for applications in bone regeneration. The addition of BG-NPs prepared by a sol-gel route to the CHT polymeric matrix improved the bioactivity of the nanocomposite scaffold, as seen by the precipitation of bone-like apatite layer upon immersion in simulated body fluid (SBF). Shape memory tests were carried out while the samples were immersed in varying compositions of water/ethanol mixtures. Dehydration with ethanol enables to fix a temporary shape of a deformed scaffold that recovers the initial geometry upon water uptake. The scaffolds present good shape memory properties characterized by a recovery ratio of 87.5% for CHT and 89.9% for CHT/BG-NPs and a fixity ratio of 97.2% for CHT and 98.2% for CHT/BG-NPs (for 30% compressive deformation). The applicability of such structures was demonstrated by a good geometrical accommodation of a previously compressed scaffold in a bone defect. The results indicate that the developed CHT/BG-NPs nanocomposite scaffolds have potential for being applied in bone tissue engineering. (C) 2015 Elsevier Ltd. All rights reserved.
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