期刊
ADVANCED FUNCTIONAL MATERIALS
卷 25, 期 38, 页码 6122-6130出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201502420
关键词
cell capture; circulating tumor cells; nanostructures; poly(aminophenylboronic acid); synergistic effects
类别
资金
- National 973 Basic Research Program [2012CB933800]
- National Natural Science Foundation of China [21275070, 21275071, 21327902]
A strategy is proposed to achieve an enhanced capture efficiency of and low damage to human leukemic lymphoblasts (CCRF-CEM) by the synergistic effect of topographical interactions and phenylboronic acid functional groups on nanostructures. To realize this purpose, a simple and template free method to synthesize boronic acid derivative polyaniline bioinspired nanostructures with controlled morphology is established. Different nanostructured morphologies such as nanotexture, nanofibers, nanoparticles, microsphere, and 3D porous network have been prepared by controlling the nucleation and growth rate for polymerization. The phenylboronic acid functional groups on the surface of the nanostructures during polymerization are used as artificial lectins to reversibly capture and release circulating tumor cells (CTCs) with little damage to the cells. The method presented here is simple, rapid, and highly efficient for CTC capture and release with low cost in materials and instruments.
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