期刊
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
卷 921, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jelechem.2022.116686
关键词
Abused drugs; Methamphetamine; Biosensors; Electrochemical biosensors; Aptasensors
资金
- Republic of Turkey, Ministry of Development [2016 K121190]
- Ege University Scienti fi c Research Projects Coordination Unit [18 -FEN -006]
An aptamer-based electrochemical biosensor was developed for the analysis of methamphetamine. The sensor exhibited good selectivity and a low limit of detection, making it suitable for the detection of methamphetamine in synthetic urine samples.
An aptamer-based electrochemical biosensor was designed and fabricated for methamphetamine (METH) anal-ysis. Several aptamer sequences developed by the GO-SELEX method were immobilized onto gold electrodes (GE) via gold-thiol affinity. Surface characterizations were performed by electrochemical methods including cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectrometry (EIS). GE/Apta-4/METH aptasensor was selected for further studies since the best results were obtained with the Apta-4 sequence in terms of analytical parameters. Accordingly, it exhibited good selectivity for METH analysis with a wide linear range of 0.1-50 ng/mL and a low limit of detection (LOD) which was found to be 0.467 ng/mL. The proposed aptasensor platform displayed good selectivity for the detection of METH in synthetic urine samples spiked with METH.
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