期刊
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
卷 77, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jddst.2022.103842
关键词
Fucoxanthin; Mesoporous silica; Metal -polyphenol network; Nano -carrier
资金
- General research project of education department of Zhejiang Province [Y202147540]
- National Natural Science Foundation of China [21476212]
- National undergraduate training program for innovation and entrepreneurship [202110340002]
Fucoxanthin, a natural carotenoid pigment found in brown seaweed, has shown antitumor activity. However, its effectiveness as a therapeutic agent is limited due to low bioavailability, poor water solubility, and poor physicochemical stability. In this study, a targeted magnetic, acid-labile nano-carrier was designed and constructed to improve the bioactivity of Fucoxanthin based on the acidic nature of the tumor microenvironment. The nano-carrier exhibited sustained and pH-dependent drug release, leading to improved stability and bioavailability of Fucoxanthin.
Fucoxanthin (FX) is a natural carotenoid pigment that exhibits antitumor activity and is found primarily in brown seaweed. However, its effectiveness as a therapeutic agent varies owing to low bioavailability, poor water solubility, and poor physicochemical stability. The acidic nature of the tumor microenvironment may be utilized to design and construct a targeted magnetic, acid-labile nano-carrier (FX@Fe3O4-mSiO2-TA) with improved FX bioactivity. A nano-drug delivery system composed of magnetic mesoporous silica coated with a tannic acid-iron network (TA/Fe3+) was designed and constructed to improve FX bioactivity based on pH and magnetic targeting in a tumor microenvironment. The external magnetic field guided the carrier to the tumor site. TA/Fe3+ in the outer coating of the carrier was decomposed, resulting in FX release, which was attributed to the low pH of the tumor microenvironment. Drug release was sustained and pH-dependent in vitro, which significantly improved the stability and bioavailability of FX. The simplicity of its preparation and efficacy of the targeted therapeutic suggest the potential of this nano-carrier for application in tumor therapy.
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