Development of β-cyclodextrin/chitosan-co-poly (2-acrylamide-2-methylpropane sulphonic acid) cross-linked hybrid IPN-nanogels to enhance the solubility of rosuvastatin: An in vitro and in vivo attributes

Recent study designed to fabricate and analyse interpenetrating polymer network (IPN) nanogels using combination of hydrophilic polymers beta-cyclodextrin (beta-CD) and chitosan (CS) for enhancing the solubility of rosuvastatin (RST). Grafting was effectively conducted by freeradical polymerization method. Spongy nano matrices were evaluated by percentage drug entrapment, zeta sizer, solubility studies, sol-gel analysis, FTIR, powder X-ray diffraction, TGA, DSC, XRD, SEM, swelling studies, and in vitro studies. Acute oral toxicity evaluation were carried out to analyse the safety of oral administration of prepared beta-CD/CS-co- poly(AMPS) IPN nanogels. Porous and spongy network were confirmed by SEM images. Complex development and thermal constancy of components were analyzed by FTIR, TGA, and DSC spectra. XRD analysis discovered decrease in Rosuvastatin crystallinity in spongy matrices. Particle size of optimized preparation was calculated in the range of 182 +/- 3.48 nm. The significant modification with reference product approved that drug solubility and release parameters were evidently improved by the fabricated nanogels. Toxicity evaluation validated that prepared nanogels were non-toxic and well-suited to biological system. In vivo experiments on developed nanogels in hyperlipidemic induced animals were examined to observe the antihyperlipidic efficiency. Efficient method of fabrication, excellent physicochemical properties, improved dissolution, high solubilization, and nontoxic nanogels might be a capable methodology for the oral administration of poorly water-soluble drugs.

Automated summary

This study aimed to develop and analyze interpenetrating polymer network (IPN) nanogels using hydrophilic polymers beta-cyclodextrin (beta-CD) and chitosan (CS) to enhance the solubility of rosuvastatin (RST). The fabricated nanogels showed improved drug solubility and release parameters, as well as good physicochemical properties and biocompatibility. In vivo experiments demonstrated the antihyperlipidic efficiency of the developed nanogels in hyperlipidemic induced animals.