Diabetes and the treatment of ischemic stroke

This white paper examines the current challenges for treating ischemic stroke in diabetic patients. The need for a greater understanding of the mechanisms that underlie the relationship between diabetes and the cerebral vascular responses to ischemia is discussed. The critical need to improve the efficacy and safety of thrombolysis is addressed, as is the need for a better characterization the off-target actions of tPA, the only currently approved thrombolytic for the treatment of ischemic stroke.

Automated summary

This white paper examines the current challenges in treating ischemic stroke in diabetic patients, emphasizing the need for a greater understanding of the mechanisms underlying the relationship between diabetes and cerebral vascular responses to ischemia. It also addresses the critical need to improve the efficacy and safety of thrombolysis, as well as the need for better characterization of the off-target actions of tPA, the only currently approved thrombolytic for ischemic stroke treatment.