期刊
JOURNAL OF DERMATOLOGICAL TREATMENT
卷 34, 期 1, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2022.2131703
关键词
Atopic dermatitis; prebiotics; postbiotics; Quality of Life; PRURISCORE
类别
This study aimed to investigate the efficacy and tolerability of a cream containing a mixture of prebiotics and postbiotics, and validate the PRURISCORE itch scale for managing atopic dermatitis. The results showed that the cream demonstrated good efficacy and tolerability in all age groups, with significant decreases in SCORAD, PRURISCORE, and IGA scores over the course of the study. The majority of patients preferred using PRURISCORE over the VAS scale.
Aim: To investigate the efficacy and tolerability of a cream (Rilastil Xerolact PB) containing a mixture of prebiotics and postbiotics, and to validate the PRURISCORE itch scale in the management of atopic dermatitis. Methods: The study is based on 396 subjects of both sexes in three age groups (i.e., infants, children, adults) suffering from mild/moderate Atopic Dermatitis, recruited from 8 European countries and followed for 3 months. Results: The product demonstrated good efficacy combined with good/very good tolerability in all age groups. In particular, SCORAD, PRURISCORE and IGA scores decreased significantly over the course of the study. The PRURISCORE was preferred to VAS by the vast majority of patients. Conclusion: Even though the role of prebiotics and postbiotics was not formally demonstrated since these substances were part of a complex formulation, it can be reasonably stated that prebiotics and postbiotics have safety and standardization features that probiotics do not have. In addition they are authorized by regulatory authorities, whereas topical probiotics are not.
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