4.1 Article

Line-field confocal optical coherence tomography of lentigo maligna with horizontal and vertical histopathologic correlations

期刊

JOURNAL OF CUTANEOUS PATHOLOGY
卷 50, 期 2, 页码 118-122

出版社

WILEY
DOI: 10.1111/cup.14321

关键词

dermoscopy; diagnosis; histopathology; lentigo maligna; line-field confocal optical coherence tomography

向作者/读者索取更多资源

Lentigo maligna is a subtype of melanoma that typically affects elderly patients and may progress into invasive melanoma. Line-field confocal optical coherence tomography (LC-OCT) is a promising non-invasive technique for real-time skin imaging, showing high-resolution features of LM which correlate strongly with histopathological findings. This study demonstrates the potential of LC-OCT to enhance the non-invasive diagnosis of LM.
Lentigo maligna (LM) is a subtype of in situ melanoma that classically presents in elderly patients as a slowly growing lesion on sun-exposed areas that may evolve to invasive melanoma. Line-field confocal optical coherence tomography (LC-OCT) is a new non-invasive technique for a real-time, vertical, and horizontal skin imaging with high resolution close to conventional histopathology. We present the LC-OCT features of an LM of the nose in a 49-year-old white man along with their horizontal and vertical histopathological correlations. LC-OCT was able to detect in vivo, in both horizontal and vertical imaging, the main microscopic features typical of LM by showing, in the epidermis and around the hair follicles, the presence of large, bright roundish, or dendritic atypical cells, with evident nuclei, corresponding to atypical melanocytes with a tendency toward folliculotropism. A strong correspondence between LC-OCT images and vertical and horizontal histopathological sections was observed. Our study, although related to a single case, is indicative of the great potential of LC-OCT to improve the non-invasive diagnosis of LM.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.1
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据