4.8 Review

Advancements of Prussian blue-based nanoplatforms in biomedical fields: Progress and perspectives

期刊

JOURNAL OF CONTROLLED RELEASE
卷 351, 期 -, 页码 752-778

出版社

ELSEVIER
DOI: 10.1016/j.jconrel.2022.10.007

关键词

Prussian blue nanoparticles; Biomimetic enzyme; Diagnosis; Drug delivery; Therapies

资金

  1. National Natural Science Foundation of China [82204287]

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Prussian blue (PB) nanoparticles have shown great potential for a variety of biomedical applications, including tumor therapy, cardiovascular and cerebrovascular diseases, bacterial infections, and other inflammation-related diseases, with their excellent physicochemical properties and diverse functions.
Prussian blue (PB) nanoparticles possess excellent physicochemical properties, including imaging features, robust photothermal conversion ability, catalytic activity, surface modifiability, effective drug loading, good stability, biocompatibility and biodegradability. With the advancement of nanotechnology, diverse PB-based nanoplatforms have been developed for biomedical applications. This review systematically summarized recent studies on PB-based nanoplatforms in the treatment of tumor (photothermal therapy, photodynamic therapy, chemotherapy, immunotherapy, theranostics, etc.), cardiovascular and cerebrovascular diseases (restenosis, atherosclerosis, thrombosis, ischemic stroke, etc.), bacterial infections (photothermal sterilization, biofilms disruption, etc.), and other inflammation-related diseases (liver injury, acute pancreatitis, inflammatory bowel disease, osteoarthritis, etc.). Finally, the existing challenges associated with current studies are discussed, and the future possible research and application directions for PB-based nanoplatforms are proposed, providing paradigms for subsequent development.

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