☆ 4.8 Review

Progress and prospects of nanomaterials against resistant bacteria

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Engineering, Biomedical

Pd-Cu nanoalloy for dual stimuli-responsive chemo-photothermal therapy against pathogenic biofilm bacteria

Zefeng Wang et al.

Summary: The study developed a near infrared/pH dual stimuli-responsive activated procedural antibacterial system that combines enhanced antibiotic delivery with photothermal therapy, showing highly efficient antimicrobial activity. The system utilizes chemotherapy followed by photothermal therapy to achieve high inhibition rates for Staphylococcus aureus and Pseudomonas aeruginosa.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Multidisciplinary

Cascade-Targeting Poly(amino acid) Nanoparticles Eliminate Intracellular Bacteria via On-Site Antibiotic Delivery

Wenli Feng et al.

Summary: A cascade-targeting drug delivery system has been developed to sequentially target macrophages and intracellular bacteria, allowing on-site drug delivery. The system encapsulates rifampicin into mannose-decorated nanoparticles, which are designed to specifically target macrophages and then release the drug in acidic environments to effectively eliminate intracellular bacteria. The system also modulates the innate immune response of infected macrophages, enhancing antibacterial capacity.

ADVANCED MATERIALS (2022)

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Review Medicine, Research & Experimental

Nano drug delivery in intracellular bacterial infection treatments

Seyed Mostafa Hosseini et al.

Summary: This review discusses the potential mechanisms used by macrophages to kill intracellular bacteria, the entry of bacteria into cells, mechanisms of escape from cellular immunity, and the applications of various nano-particles. Nano drug-based therapeutics show promise in treating intracellular bacteria and preventing disease recurrence, thanks to their small size and ability to target specific locations.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Microbiology

Physical properties of the bacterial outer membrane

Jiawei Sun et al.

Summary: This review discusses the emerging physical and mechanical properties of the Gram-negative outer membrane, revealing a more expansive and versatile role in cellular physiology and viability. Recent studies have uncovered key molecular factors and interactions through experimental and computational research, while advancements in microfluidics and microscopy have contributed to a better understanding of the structural, rheological, and mechanical properties of the outer membrane. These findings suggest broader connections between cellular structure and physiology, with future prospects for elucidating the implications of outer membrane construction for cellular fitness and survival.

NATURE REVIEWS MICROBIOLOGY (2022)

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Review Microbiology

Tolerance and resistance of microbial biofilms

Oana Ciofu et al.

Summary: Chronic infections caused by microbial biofilms pose a significant clinical challenge due to the resistance of biofilms to antimicrobials and the immune system, leading to persistent and recurrent infections. This Review discusses the current understanding of the mechanisms underlying the tolerance of biofilms to the immune system and to antimicrobials, as well as their role in the development of antimicrobial resistance.

NATURE REVIEWS MICROBIOLOGY (2022)

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Article Chemistry, Multidisciplinary

Dual Drug Loaded pH-sensitive Micelles for Efficient Bacterial Infection Treatment

Yingxian Chen et al.

Summary: The micelles loaded with Quercetin and Rifampicin can penetrate the MRSA biofilm and kill bacteria, as well as improve drug delivery to epithelial cells. Compared with free drugs, the micelles have a stronger ability to promote cell migration and proliferation.

PHARMACEUTICAL RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Silver Peroxide Nanoparticles for Combined Antibacterial Sonodynamic and Photothermal Therapy

Xuelong Bi et al.

Summary: Silver peroxide nanoparticles are capable of controlled release of reactive oxygen species under external stimuli of ultrasound and near-infrared light. They exhibit enhanced antibacterial and antibiofilm capabilities, accelerate wound closure and kill multi-drug resistant Staphylococcus aureus. Additionally, they show excellent cytocompatibility and hemocompatibility.

SMALL (2022)

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Article Materials Science, Biomaterials

Te-Cefotaxime nanocomposites with restored antibiotic susceptibility and the LED light activated photothermal effect for rapid MRSA eradication

Shaomin Wu et al.

Summary: Te NPs loaded with cefotaxime (CTX) were able to restore the antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and perform photothermal therapy under LED irradiation. This combination provided an innovative way for the treatment of antibiotic-resistant bacterial infections.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Microbiology

Targeted Antimicrobial Photodynamic Therapy of Biofilm-Embedded and Intracellular Staphylococci with a Phage Endolysin’s Cell Binding Domain

Mafalda Bispo et al.

Microbiology Spectrum (2022)

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Article Nanoscience & Nanotechnology

Charge-Switchable CuxO Nanozyme with Peroxidase and Near-Infrared Light Enhanced Photothermal Activity for Wound Antibacterial Application

Shaoying He et al.

Summary: In this study, a multifunctional nanozyme, CuxO-PDA, was designed to enhance the antibacterial effect. CuxO-PDA showed enhanced catalytic activity under near-infrared irradiation, and had the ability to target bacteria and trap them together.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Environmental

Photothermally activated multifunctional MoS2 bactericidal nanoplatform for combined chemo/photothermal/photodynamic triple-mode therapy of bacterial and biofilm infections

Huan Li et al.

Summary: The study introduces a photothermal-activated multifunctional nano-antibacterial platform, which can perform triple-mode antibacterial therapy through combined chemo/photothermal/photodynamic capabilities under a single laser irradiation, effectively inhibiting biofilm formation and eradicating deep-seated bacteria.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Environmental

An electromagnetically actuated magneto-nanozyme mediated synergistic therapy for destruction and eradication of biofilm

Xinxin Ma et al.

Summary: The study proposes an electromagnetically actuated magneto-nanozyme mediated synergistic therapy (EMST) with powerful potential to eradicate biofilm. Through magnetic hyperthermia and generation of reactive oxygen species, this method effectively eliminates biofilm infections by combining physical and chemical bactericidal effects.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Chemistry, Multidisciplinary

NIR responsive nitric oxide nanogenerator for enhanced biofilm eradication and inflammation immunotherapy against periodontal diseases

Manlin Qi et al.

Summary: This study successfully developed a near-infrared light triggered nanoplatform with dual functions of antibacterial and anti-inflammatory effects. It can effectively treat periodontal disease by killing bacteria and dispersing biofilms, as well as inhibiting inflammation through the release of gas molecules. The nanoplatform shows promising therapeutic potential for periodontal diseases and other refractory infections in deep tissues.

NANO TODAY (2022)

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Article Biochemistry & Molecular Biology

Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus

Douglas N. Brawley et al.

Summary: This study identified synthetic antigen-binding fragments (Fabs) that inhibit the quinolone transporter NorA in methicillin-resistant Staphylococcus aureus (MRSA), effectively blocking MRSA growth. The Fabs interact with essential residues in NorA's substrate-binding pocket, inhibiting the efflux of antibiotics and enhancing the efficacy of existing drugs. These findings present a new class of peptide inhibitors that target specific residues in NorA, providing a potential strategy to combat antibiotic resistance in MRSA.

NATURE CHEMICAL BIOLOGY (2022)

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Article Engineering, Biomedical

Acid-Responsive Nanoporphyrin Evolution for Near-Infrared Fluorescence-Guided Photo-Ablation of Biofilm

Mengyao Yang et al.

Summary: This study develops an acid-responsive nanoporphyrin for accurate diagnosis and treatment of biofilm infections, avoiding damage to normal tissue and offering a promising alternative to antibiotics.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Functionalized Concave Cube Gold Nanoparticles as Potent Antimicrobial Agents against Pathogenic Bacteria

Satya Ranjan Sarker et al.

Summary: In this study, functionalized concave cube gold nanoparticles (CCAuNPs) were prepared and modified with natural antioxidant lipoic acid and tripeptide glutathione. The functionalized nanoparticles exhibited high antibacterial activity against bacteria by damaging the bacterial cell wall and causing oxidation of bacterial cell membrane fatty acids. Additionally, the nanoparticles showed excellent hemocompatibility and biocompatibility to human red blood cells and various cell lines.

ACS APPLIED BIO MATERIALS (2022)

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Article Materials Science, Biomaterials

Graphitic-N-doped graphene quantum dots for photothermal eradication of multidrug-resistant bacteria in the second near-infrared window

Bijiang Geng et al.

Summary: In this study, highly graphitic-N-doped graphene quantum dots with efficient NIR-II photothermal conversion properties were synthesized for the first time and used for photothermal antibacterial therapy. In vivo investigations showed that these quantum dots can effectively combat multidrug-resistant bacterial infections and accelerate wound healing.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Biochemistry & Molecular Biology

In Vivo and In Vitro Assessments of the Antibacterial Potential of Chitosan-Silver Nanocomposite Against Methicillin-Resistant Staphylococcus aureus-Induced Infection in Rats

Eman Hassanen et al.

Summary: The study compared the bactericidal effects of nanoparticles of chitosan, silver, and chitosan-silver nanocomposites against MRSA, showing that Ch-Ag NCs exhibited the strongest bactericidal effect and may be a potential alternative to antibiotics.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Article Engineering, Environmental

Recoverable peroxidase-like Fe3O4@MoS2-Ag nanozyme with enhanced antibacterial ability

Feng Wei et al.

Summary: The study successfully demonstrated the efficient antibacterial performance of Fe3O4@MoS2-Ag nanozyme against E. coli, and revealed a synergistic disinfection effect. Through the collaborative work of peroxidase-like activity, photothermal effect, and Ag+ leakage, the nanozyme could accurately and rapidly attack bacterial membranes, showing broad-spectrum antibacterial capabilities.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Biology

Osmotic stress and vesiculation as key mechanisms controlling bacterial sensitivity and resistance to TiO2 nanoparticles

Christophe Pagnout et al.

Summary: This study investigates the response of lipopolysaccharide-truncated Escherichia coli mutants to TiO2 nanoparticles, showing that different lipopolysaccharide surface phenotypes can affect bacterial sensitivity to the nanoparticles. TiO2 nanoparticles strip the cell membrane, leading to osmotic stress, oxidative stress, and the formation of membrane vesicles, which can act as electrostatic baits for the nanoparticles, highlighting an antagonistic bacterial response to nanoparticle toxicity.

COMMUNICATIONS BIOLOGY (2021)

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Review Nanoscience & Nanotechnology

Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents

Stephen Amankwah et al.

Summary: Biofilms are bacterial communities that pose a major threat causing chronic infections on both biotic and abiotic surfaces, including human tissue and medical device surfaces. The use of phages and phage-derived enzymes can combat bacteria in biofilm structures, but may not completely eradicate all bacterial cells. Combining phages and/or phage-derived products with other antimicrobial agents like antibiotics, nanoparticles, and antimicrobial peptides could be an effective approach to remove biofilms and treat associated infections.

NANOTECHNOLOGY SCIENCE AND APPLICATIONS (2021)

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Review Microbiology

Mechano-bactericidal actions of nanostructured surfaces

Denver P. Linklater et al.

Summary: Antibiotic resistance poses a global health threat, while newly developed antibacterial nanostructured surfaces demonstrate promising prospects in medicine, showing potential for playing a crucial role in preventing bacterial infections.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Biochemical Research Methods

Zinc oxide nanoparticles inhibit bacterial biofilm formation via altering cell membrane permeability

Tanvir Kaur et al.

Summary: The biogenic synthesis of zinc oxide nanoparticles showed significant antibacterial and anti-biofilm activity against various bacterial strains. The nanoparticles caused changes in bacterial cell membrane permeability, leading to leakage of nucleic acid, which likely contributed to their anti-biofilm potential.

PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY (2021)

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Article Instruments & Instrumentation

Inhalable solid lipid nanoparticles for intracellular tuberculosis infection therapy: macrophage-targeting and pH-sensitive properties

Cheng Ma et al.

Summary: A mannose-modified macrophage-targeting solid lipid nanoparticle loaded with a pH-sensitive prodrug of isoniazid was designed to treat latent tuberculosis infection, demonstrating a promising platform for the disease.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Nanoscience & Nanotechnology

A pH-Responsive Persistent Luminescence Nanozyme for Selective Imaging and Killing of Helicobacter pylori and Common Resistant Bacteria

Li-Xia Yan et al.

Summary: A novel pH-responsive nanozyme was reported for in vivo imaging and inactivation of H. pylori, showing multifunctional properties for targeted imaging and activated deactivation of the bacteria under extreme gastric acid conditions. This promising nanozyme platform has the potential to combat other bacterial infections as well.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Microbiology

A Novel Transferable Resistance-Nodulation-Division Pump Gene Cluster, tmexCD2-toprJ2, Confers Tigecycline Resistance in Raoultella ornithinolytica

Cheng-Zhen Wang et al.

Summary: The study identified a novel mobile gene cluster, tmexCD2-toprJ2, present in Raoultella ornithinolytica, which confers resistance to multiple antimicrobials and may have originated from a Pseudomonas species. The expression of tmexCD2-toprJ2 in Escherichia coli resulted in increased resistance to tigecycline and decreased susceptibility to other antimicrobials. Genetic context analyses demonstrated that tmexCD2-toprJ2 might have been captured and mobilized by a XerD-like tyrosine recombinase system.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Article Chemistry, Physical

Construction of silver nanoparticles anchored flower-like magnetic Fe3O4@SiO2@MnO2 hybrids with antibacterial and wound healing activity

Hang Jia et al.

Summary: The study reported the application of flower-like silver nanoparticles anchored hybrids in controlling pathogenic bacteria and promoting wound healing. Experimental results showed that the material exhibited high inhibitory effects against Escherichia coli and Staphylococcus aureus.

APPLIED SURFACE SCIENCE (2021)

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Article Chemistry, Applied

Composite inclusion complexes containing hyaluronic acid/chitosan nanosystems for dual responsive enrofloxacin release

Yuda Liu et al.

Summary: This study explores a pH/hyaluronidase dual-responsive nano-system for targeted treatment of Staphylococcus aureus infections. The nano-system shows excellent stability and responsive release, displaying strong surface adsorption on S. aureus and enhanced activity against it.

CARBOHYDRATE POLYMERS (2021)

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Article Biochemistry & Molecular Biology

Single-Chain Nanoparticle-Based Coatings with Improved Bactericidal Activity and Antifouling Properties

Xinyun Tian et al.

Summary: The study reported the preparation and properties of a novel antibacterial coating with improved bactericidal and antifouling properties. Experimental results demonstrated that the coating exhibited superior bactericidal activity and antifouling properties against Staphylococcus aureus and Escherichia coli.

BIOMACROMOLECULES (2021)

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Article Engineering, Environmental

Effective adsorption of dyes on an activated carbon prepared from carboxymethyl cellulose: Experiments, characterization and advanced modelling

Huifeng Wang et al.

Summary: An activated carbon with high surface area and outstanding adsorption properties was prepared for dye removal from water, obtained from the chemical activation and pyrolysis of sodium carboxymethyl cellulose. Different characterization techniques and experimental adsorption isotherms at different temperatures were utilized to interpret the dye adsorption mechanism. Overall, the new adsorbent showed competitive performance for dye removal in aqueous solution.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Photodynamic and photothermal co-driven CO-enhanced multi-mode synergistic antibacterial nanoplatform to effectively fight against biofilm infections

Xiaojun Cai et al.

Summary: A CO-enhanced multi-mode synergistic antibacterial nanoplatform (ICG&CO@G3KBPY) has been successfully developed to combat biofilm infections, with enhanced biofilm penetration, antibacterial activity, and anti-inflammatory effects. The platform rapidly generates CO under the co-driven effects of PTT and PDT, significantly improving the efficacy of biofilm eradication while alleviating inflammation caused by bacterial infection, PTT, and PDT. This study provides an efficient and safe multi-mode synergistic antibacterial strategy for treating biofilm infections.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Biophysics

Polyethylene imine conjugated supramolecular stereocomplexed nanomicelles for intracellular delivery of rifampicin against Mycobacterium bovis

Maria Hassan Kiani et al.

Summary: This study investigated PEI-based stereocomplexed nanomicelles for intracellular delivery of rifampicin against M. bovis. The synthesized StM showed higher encapsulation efficiency, drug release performance, and antimycobacterial activity compared to isotactic nanomicelles. In vivo evaluation demonstrated that drug-loaded StM had higher distribution in macrophage rich organs with longer half-life and improved efficacy, indicating maximum bioavailability and reduced dosing frequency.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Biochemistry & Molecular Biology

Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance

Maxim S. Svetlov et al.

Summary: Structural analysis reveals the resistance mechanism of macrolide antibiotics, mainly through A2058 dimethylation. The study found that the desosamine moiety plays a crucial role in drug binding, providing a foundation for the rational design of macrolides to overcome Erm-mediated resistance.

NATURE CHEMICAL BIOLOGY (2021)

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Article Chemistry, Physical

Gold nanocluster surface ligand exchange: An oxidative stress amplifier for combating multidrug resistance bacterial infection

Jie Meng et al.

Summary: The development of an oxidative stress amplifier using a ligand exchange strategy on gold nanoclusters has shown promising antibacterial effects against methicillin-resistant Staphylococcus aureus. This innovative approach disrupts the redox balance in bacteria and offers a potential antibacterial therapy.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Engineering, Biomedical

PAMAM dendrimers with dual-conjugated vancomycin and Ag-nanoparticles do not induce bacterial resistance and kill vancomycin-resistant Staphylococci

Guimei Jiang et al.

Summary: The decreasing effective life-time of new antimicrobials before the appearance of resistant strains discourages commercialization, highlighting the importance of developing antimicrobials that prevent resistance induction. Heterofunctionalized dendrimers have shown the ability to kill resistant pathogens without inducing resistance in susceptible strains, providing a promising strategy for using existing antibiotics effectively. This approach may lead to better utilization of antibiotics and facilitate their clinical translation.

ACTA BIOMATERIALIA (2021)

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Article Nanoscience & Nanotechnology

Enzyme-Functionalized Mesoporous Silica Nanoparticles to Target Staphylococcus aureus Disperse Biofilms

Henry Devlin et al.

Summary: The study demonstrates that enzyme-functionalized mesoporous silica nanoparticles can significantly enhance the efficacy of three enzymes against Staphylococcus aureus cells and biofilms. The combined use of these enzymes further improves treatment efficacy, particularly for methicillin-resistant Staphylococcus aureus infections, showing potential for clinical applications.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Chemistry, Physical

Enhanced photodynamic inactivation for Gram-negative bacteria by branched polyethylenimine-containing nanoparticles under visible light irradiation

Qian Wang et al.

Summary: In this study, a chlorine-loaded polyethyleneimine-based micelle photosensitizer was constructed for enhanced photoinactivation activities on Gram-negative bacteria through electrostatic and hydrophobic interactions between nanoparticles and the bacterial surface. The light-triggered generation of reactive oxygen species caused irreversible damage to the bacterial outer membrane, achieving enhanced bactericidal efficiency. This antimicrobial alternative holds great potential for human healthcare and environmental remediation.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Reversing Bacterial Resistance to Gold Nanoparticles by Size Modulation

Wenshu Zheng et al.

Summary: One major obstacle in antibiotic development is bacterial resistance, but this study demonstrates a novel gold nanoparticle with antibacterial properties that can slow down the development of resistance, providing a new approach for treating multidrug-resistant bacterial infections.

NANO LETTERS (2021)

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Review Chemistry, Physical

New Perspectives of Using Chitosan, Silver, and Chitosan-Silver Nanoparticles against Multidrug-Resistant Bacteria

Marcos A. Polinarski et al.

Summary: Nanomaterials with antimicrobial activity, such as CsNPs and AgNPs, have shown great potential in overcoming microbial resistance in medical devices. The synergistic effect between chitosan and silver in Cs-AgNPs makes them more effective against various microorganisms, including multidrug-resistant bacteria. Various synthesis methods and physicochemical characteristics of these nanoparticles are discussed in this review, highlighting their antimicrobial properties in medical, pharmaceutical, and biotechnological applications.

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (2021)

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Article Environmental Sciences

Resistance of multidrug resistant Escherichia coli to environmental nanoscale TiO2 and ZnO

Wei Yuan et al.

Summary: The study shows that multidrug-resistant E. coli LM13 can counteract the antibacterial activities of TiO2 and ZnO NPs through an efflux pump and other regulatory genes, while also exhibiting higher resistance to NPs compared to susceptible E. coli strain ATCC25922. Additionally, the research demonstrates that the intensity of side-scatter light parameter increases with TiO2 and ZnO NPs in a dose-dependent manner, indicating NP uptake by both strains.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Biotechnology & Applied Microbiology

Evolution of biofilm-forming pathogenic bacteria in the presence of nanoparticles and antibiotic: adaptation phenomena and cross-resistance

Riti Mann et al.

Summary: The study found that silver nanoparticles can inhibit the formation and eradication of Pseudomonas aeruginosa biofilms, but the biofilm-forming bacteria may develop reduced sensitivity and even persister cells. Prolonged exposure to silver may lead to adaptation and potential cross-resistance to antibiotics. Furthermore, silver formulations cannot eradicate gentamicin-resistant P. aeruginosa biofilms, but they can inhibit the formation of the resistant strain, showing promise in controlling antibiotic-resistant bacteria in biofilms.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Materials Science, Multidisciplinary

Modulation of virulence factors of Staphylococcus aureus by nanostructured surfaces

Paola San-Martin-Galindo et al.

Summary: Investigating microbial response to different surfaces requires versatile parameters, including surface chemistry and topography. Surface roughness parameters influence microbial viability and exopolysaccharide abundance, with valley structures potentially increasing viability.

MATERIALS & DESIGN (2021)

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Review Pharmacology & Pharmacy

Nanotechnology-based lipid systems applied to resistant bacterial control: A review of their use in the past two decades

Matheus Aparecido dos Santos Ramos et al.

Summary: The rate of infections caused by resistant bacteria to available antimicrobials is growing exponentially, impacting human health and the global economy. Nanotechnology-based lipid systems have emerged as an innovative tool in improving bacterial infections treatment, offering potential for new antibacterial therapeutic strategies.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Infectious Diseases

Prevalence of RND efflux pump regulator variants associated with tigecycline resistance in carbapenem-resistant Acinetobacter baumannii from a worldwide survey

Kai Lucassen et al.

Summary: The most prevalent tigecycline resistance mechanisms in carbapenem-resistant Acinetobacter baumannii isolates were caused by alterations in the regulators of RND-type efflux pumps, with disruption of the adeN gene being the most common. Mutations and IS element disruptions in the adeRS regulatory system from Southern European countries were associated with higher tigecycline MICs, although less commonly observed.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

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Article Chemistry, Physical

Analysis of the structure, loading and activity of six antimicrobial peptides encapsulated in cubic phase lipid nanoparticles

Thomas G. Meikle et al.

Summary: This study utilized lipid-based cubosomes as delivery vehicles for antimicrobial peptides, increasing AMP loading efficiency by manipulating electrostatic charge and enhancing antimicrobial activity of nanoparticles. This approach provides a foundation for designing more effective and targeted antibiotic therapies.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Engineering, Chemical

Multifunctional metal-chelated phosphonate/Fe3O4 magnetic nanocomposite particles for defeating antibiotic-resistant bacteria

Neda Akhlaghi et al.

Summary: A new nanocomposite particle was synthesized and characterized to inhibit serine beta-lactamase activities, a common antibiotic resistance mechanism in bacteria. The particle was based on an ultra-small iron oxide nanocore coated with a hydrophilic and biodegradable compound, and further conjugated with a tetra-dentate molecule through chemical reactions. The resulting nanostructure showed significant inhibition of enzyme activity towards class C beta-lactamase and demonstrated synergistic effects when used in combination with cephalexin against Escherichia coli.

POWDER TECHNOLOGY (2021)

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Article Infectious Diseases

A novel mechanism of streptomycin resistance in Yersinia pestis: Mutation in the rpsL gene

Ruixia Dai et al.

Summary: This study reported high-level streptomycin resistance in a clinical Y. pestis isolate from a pneumonic patient in Tibet Autonomous Region, China, and identified a novel mechanism of streptomycin resistance. Streptomycin susceptibility monitoring of Y. pestis isolates should include not only plasmid-mediated resistance but also ribosomal protein S12 gene (rpsL) mutation.

PLOS NEGLECTED TROPICAL DISEASES (2021)

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Article Biotechnology & Applied Microbiology

On-demand pH-sensitive surface charge-switchable polymeric micelles for targeting Pseudomonas aeruginosa biofilms development

Xiangjun Chen et al.

Summary: This study developed a novel pH-sensitive micelle system that can release azithromycin-loaded cationic micelles in acidic biofilm microenvironment, enhancing drug penetration and retention within biofilms. The system showed potential as an anti-biofilm agent by improving drug-bacterium interactions and in vivo therapeutic performance.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection

Rabia Arshad et al.

Summary: The hyaluronic acid-functionalized self-nano emulsifying drug delivery system (HA-CIP-SNEDDS) effectively improved the biopharmaceutical parameters of CIP, demonstrating enhanced permeation ability through goat intestinal mucus. Compared to free CIP, HA-CIP-SNEDDS exhibited stronger anti-biofilm activity, improved biocompatibility, and enhanced oral pharmacokinetics.

NANOMATERIALS (2021)

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Article Pharmacology & Pharmacy

Bactericidal Properties of Rod-, Peanut-, and Star-Shaped Gold Nanoparticles Coated with Ceragenin CSA-131 against Multidrug-Resistant Bacterial Strains

Sylwia Joanna Chmielewska et al.

Summary: By linking cationic steroid antimicrobial ceragenin CSA-131 with gold nanoparticles Au NPs, a new class of potent nanoantibiotics with strong bactericidal activity against multidrug-resistant bacteria has been developed, showing potential for effective eradication of MDR strains.

PHARMACEUTICS (2021)

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Review Infectious Diseases

Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus

Harshad Lade et al.

Summary: MRSA is a prevalent bacterial pathogen worldwide, and finding new antibiotic targets is crucial for successful treatment. Most antibiotics target essential biochemical processes of S. aureus, such as cell wall synthesis. Further research into novel antibiotics targeting bacterial cellular processes could lead to new therapeutic strategies against antibiotic-resistant pathogens.

ANTIBIOTICS-BASEL (2021)

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Article Infectious Diseases

Biofilm and Spore Formation of Clostridium perfringens and Its Resistance to Disinfectant and Oxidative Stress

Wen Si Hu et al.

Summary: This study revealed the resistance of sessile cells and spores of C. perfringens upon exposure to stress conditions after biofilm formation.

ANTIBIOTICS-BASEL (2021)

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Article Chemistry, Multidisciplinary

Bacterial Outer Membrane-Coated Mesoporous Silica Nanoparticles for Targeted Delivery of Antibiotic Rifampicin against Gram-Negative Bacterial Infection In Vivo

Shuang Wu et al.

Summary: This study introduces a biomimetic nanodelivery system consisting of outer membrane vesicles isolated from E. coli as shell and rifampicin-loaded mesoporous silica nanoparticles as core, aiming to enhance bacterial targeting and uptake, thus improving antimicrobial activity against Gram-negative bacteria.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Chemistry, Physical

Current progress and prospects of organic nanoparticles against bacterial biofilm

Xinyao Li et al.

Summary: Biofilm plays a crucial role in bacterial pathogenicity and resistance, and exploring effective strategies to control it has become a hot research topic. Organic nanomaterials show great prospects in overcoming bacterial biofilm problems, and their unique properties make them promising in this area.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Polymers for Biomedical Applications: The Importance of Hydrophobicity in Directing Biological Interactions and Application Efficacy

Amanda K. Pearce et al.

Summary: Significant research efforts have been dedicated to exploring the potential of polymers for biomedical applications in recent decades. The properties of polymers, including chemistry, charge, and self-assembly characteristics, play a crucial role in their interactions with cells and biological membranes. Specifically, the hydrophobicity of polymers has been identified as a key property influencing their efficacy in biomedicine applications.

BIOMACROMOLECULES (2021)

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Article Engineering, Environmental

Biocidal chitosan-magnesium oxide nanoparticles via a green precipitation process

Chandrasekaran Karthikeyan et al.

Summary: This study successfully synthesized magnesium oxide and chitosan-modified magnesium oxide nanoparticles with antibacterial and anticancer activities via a green precipitation process. Results showed that CMgO NPs exhibited superior performance in both antibacterial and anticancer properties compared to MgO NPs, while also demonstrating lower toxicity to healthy cells.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Multidisciplinary Sciences

Outer membrane permeability: Antimicrobials and diverse nutrients bypass porins in Pseudomonas aeruginosa

Johanna Ude et al.

Summary: This study found that all porins in Pseudomonas aeruginosa were not essential for bacterial growth in rich medium and consumption of diverse hydrophilic nutrients. However, nutrients with multiple carboxylate groups permeated poorly in the absence of porins. Porins provided efficient pathways for nutrient uptake while effectively excluding most antibiotics except carbapenems, with outer-membrane lipid bilayer serving as a major pathway for nutrient and drug entry into the bacterial cell.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Multidisciplinary Sciences

Varied-shaped gold nanoparticles with nanogram killing efficiency as potential antimicrobial surface coatings for the medical devices

Ewelina Piktel et al.

Summary: The study synthesized a series of varied-morphology gold nanoparticles with potent antibacterial activity against a spectrum of clinical strains, including Candida albicans, Pseudomonas aeruginosa, Staphylococcus aureus, and uropathogenic Escherichia coli. The optimized synthesis of gold nanoparticles allowed for the development of nanomaterials significantly more potent than previous formulations, with antimicrobial spectrum covering strains with different drug resistance mechanisms. The research highlights the potential for using non-spherical gold nanoparticles as new coatings targeting multidrug-resistant pathogens causing device-associated infections.

SCIENTIFIC REPORTS (2021)

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Article Polymer Science

Capsule Independent Antimicrobial Activity Induced by Nanochitosan against Streptococcus pneumoniae

Fulwah Y. Alqahtani et al.

Summary: This study prepared polymeric nanoparticles (CNPs) with wide-spectrum antimicrobial activity against Streptococcus pneumoniae TIGR4 and its capsular mutant. The CNPs showed concentration-dependent reduction in bacterial hemolysis and were cytocompatible at lower concentrations, suggesting their potential in treating pneumococcal diseases.

POLYMERS (2021)

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Article Chemistry, Multidisciplinary

Hybrid Materials Based on Multi-Walled Carbon Nanotubes and Nanoparticles with Antimicrobial Properties

Madalina Elena David et al.

Summary: Multi-walled carbon nanotubes (MWCNTs) were decorated with different types of nanoparticles (NPs) to obtain hybrid materials with improved antimicrobial activity, showing good antimicrobial properties in clinically relevant microbial strains. The presence of NPs on the surface of MWCNTs enhanced the nanocomposites' activity, with zinc oxide and silver nanoparticles improving the antimicrobial properties of the material.

NANOMATERIALS (2021)

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Article Biochemistry & Molecular Biology

Selenium Nanoparticles as Candidates for Antibacterial Substitutes and Supplements against Multidrug-Resistant Bacteria

Hee-Won Han et al.

Summary: The study identified the antibacterial activity of selenium nanoparticles (SeNPs) against multidrug-resistant bacteria, particularly when combined with the conventional antibiotic linezolid. SeNPs demonstrated synergistic effects with linezolid through protein degradation against MRSA and MSSA. These results suggest the potential of SeNPs as antibacterial substitutes and supplements against MDR bacteria.

BIOMOLECULES (2021)

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Article Chemistry, Multidisciplinary

DNA Aptamer-Conjugated Magnetic Graphene Oxide for Pathogenic Bacteria Aggregation: Selective and Enhanced Photothermal Therapy for Effective and Rapid Killing

Muserref A. Ocsoy et al.

Summary: Apt@MGO is a novel nanoplatform developed for selective and rapid eradication of MRSA, showing high efficiency in killing MRSA cells under NIR laser irradiation by converting light to heat. This targeted and biocompatible photothermal agent resulted in >97% MRSA cell inactivation in the aggregated state within 200 seconds of exposure, demonstrating its potential for efficient MRSA treatment.

ACS OMEGA (2021)

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Article Microbiology

Escherichia coli: placing resistance to third-generation cephalosporins and fluoroquinolones in Australia and New Zealand into perspective

Rhys T. White

Summary: Urinary tract infections caused by uropathogenic Escherichia coli are a major global health concern, with at least 300 million cases occurring annually. The misuse of antibiotics has led to the emergence of antimicrobial resistance, particularly driven by UPEC. Evidence-based interventions using data are crucial for reducing resistance to first-line antibiotics and combating the global threat of antibiotic resistance.

MICROBIOLOGY AUSTRALIA (2021)

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Article Nanoscience & Nanotechnology

Advanced Alcalase-Coated Clindamycin-Loaded Carbopol Nanogels for Removal of Persistent Bacterial Biofilms

Paul J. Weldrick et al.

Summary: The study demonstrates the development of a highly effective agent for eradicating persistent bacterial biofilms by surface-functionalizing clindamycin-loaded nanogel particles with the cationic protease, Alcalase 2.4 L FG. The dual-functionalized antibiotic nanocarrier is capable of breaking down the extracellular polymer matrix of bacterial biofilms, attaching to bacterial cells, and delivering antibiotics directly to their cell walls. This innovative approach shows promise for enhanced antibiotic treatments of diabetic foot and chronically infected surface wounds.

ACS APPLIED NANO MATERIALS (2021)

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Review Pharmacology & Pharmacy

Insights on recent approaches in drug discovery strategies and untapped drug targets against drug resistance

Ramalingam Peraman et al.

Summary: Despite various strategies being implemented in clinical practice, the mortality rate due to antibiotic-resistant microbes is on the rise globally. In addition to multidrug-resistant microbes, ESKAPE bacteria are also becoming a concern. Drug resistance is now a prevalent issue across various therapies. The research on new antibiotics is extensive, but there is still a long way to go in finding effective solutions.

FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Insight into single-element nobel metal anisotropic silver nanoparticle shape-dependent selective ROS generation and quantification

Jabran Ahmad et al.

Summary: The study investigated the bactericidal capacity of different shapes of silver nanoparticles, with triangular shape demonstrating the best antibacterial performance at a low concentration compared to cube and rod shapes. Oxygen radicals (ROS) were found to play a crucial role in microbial mutilation, with O-2(-) identified as the dominant species among ROS. Geometrical shape and attachment to bacterial surface were found to be of paramount significance in physically deteriorating bacterial cells.

RSC ADVANCES (2021)

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Article Biochemistry & Molecular Biology

The Efficacy of Imipenem Conjugated with Synthesized Silver Nanoparticles Against Acinetobacter baumannii Clinical Isolates, Iran

Elham Zendegani et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2020)

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Article Nanoscience & Nanotechnology

Nanosilver Targets the Bacterial Cell Envelope: The Link with Generation of Reactive Oxygen Radicals

Cindy Gunawan et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination

Zhang Yuan et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Light-Activatable Synergistic Therapy of Drug-Resistant Bacteria-Infected Cutaneous Chronic Wounds and Nonhealing Keratitis by Cupriferous Hollow Nanoshells

Yue Qiao et al.

ACS NANO (2020)

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Article Biophysics

Amphiphilic p-sulfonatocalix[6]arene based self-assembled nanostructures for enhanced clarithromycin activity against resistant Streptococcus Pneumoniae

Imdad Ali et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Pharmacology & Pharmacy

Preparation of PLGA-chitosan based nanocarriers for enhancing antibacterial effect of ciprofloxacin in root canal infection

Mona G. Arafa et al.

DRUG DELIVERY (2020)

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Article Chemistry, Physical

Novel g-C3N4 assisted metal organic frameworks derived high efficiency oxygen reduction catalyst in microbial fuel cells

Yan Wang et al.

JOURNAL OF POWER SOURCES (2020)

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Article Infectious Diseases

Prevalence of Genes Involved in Colistin Resistance inAcinetobacter baumannii:First Report from Iraq

Israa M. S. Al-Kadmy et al.

MICROBIAL DRUG RESISTANCE (2020)

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Article Chemistry, Multidisciplinary

Biocompatible Hybrid Organic/Inorganic Microhydrogels Promote Bacterial Adherence and Eradication in Vitro and in Vivo

Lee Schnaider et al.

NANO LETTERS (2020)

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Article Nanoscience & Nanotechnology

Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis

Xucheng Hou et al.

NATURE NANOTECHNOLOGY (2020)

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Article Nanoscience & Nanotechnology

Submicrometer-Sized Roughness Suppresses Bacteria Adhesion

Noemi Encinas et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Size and Charge Adaptive Clustered Nanoparticles Targeting the Biofilm Microenvironment for Chronic Lung Infection Management

Yifan Gao et al.

ACS NANO (2020)

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Article Biotechnology & Applied Microbiology

Inhibition of methicillin-resistant Staphylococcus aureus (MRSA) biofilm by cationic poly (D, L-lactide-co-glycolide) nanoparticles

Yang Qiu et al.

BIOFOULING (2020)

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Review Immunology

Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus

Yunlei Guo et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Chemistry, Multidisciplinary

Combating Antibiotic Resistance through the Synergistic Effects of Mesoporous Silica-Based Hierarchical Nanocomposites

Ranjith Kumar Kankala et al.

NANOMATERIALS (2020)

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Article Biochemistry & Molecular Biology

Biofilm Eradication Using Biogenic Silver Nanoparticles

Maria Belen Estevez et al.

MOLECULES (2020)

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Article Chemistry, Multidisciplinary

Intracellular bacteria destruction via traceable enzymes-responsive release and deferoxamine-mediated ingestion of antibiotics

Maohua Chen et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Biology

Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance

Andrew J. Gasparrini et al.

COMMUNICATIONS BIOLOGY (2020)

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Article Chemistry, Physical

Biofilm-Responsive Polymeric Nanoparticles with Self-Adaptive Deep Penetration for In Vivo Photothermal Treatment of Implant Infection

Congyu Wang et al.

CHEMISTRY OF MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Self-Propelled Active Photothermal Nanoswimmer for Deep-Layered Elimination of Biofilm In Vivo

Tingting Cui et al.

NANO LETTERS (2020)

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Article Engineering, Biomedical

Antibacterial nanotruffles for treatment of intracellular bacterial infection

Marwa G. Elnaggar et al.

BIOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

Antibacterial Effect of Chitosan-Gold Nanoparticles and Computational Modeling of the Interaction between Chitosan and a Lipid Bilayer Model

M. G. Fuster et al.

NANOMATERIALS (2020)

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Article Multidisciplinary Sciences

Nano-MOFs as targeted drug delivery agents to combat antibiotic-resistant bacterial infections

Saleh A. Ahmed et al.

ROYAL SOCIETY OPEN SCIENCE (2020)

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Article Nanoscience & Nanotechnology

Size-Dependent Bioactivity of Silver Nanoparticles: Antibacterial Properties, Influence on Copper Status in Mice, and Whole-Body Turnover

Ekaterina A. Skomorokhova et al.

NANOTECHNOLOGY SCIENCE AND APPLICATIONS (2020)

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Review Biochemistry & Molecular Biology

Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy

Maxime Klausen et al.

MOLECULES (2020)

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Article Materials Science, Biomaterials

Silver-decorated, light-activatable polymeric antimicrobials for combined chemo-photodynamic therapy of drug-resistant bacterial infection

Xiaoxue Hou et al.

BIOMATERIALS SCIENCE (2020)

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Article Infectious Diseases

Carbapenemase-producing Enterobacteriaceae in a Portuguese hospital - a five-year retrospective study

Ana Gorgulho et al.

GERMS (2020)

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Review Chemistry, Multidisciplinary

Antibiotic resistance: bioinformatics-based understanding as a functional strategy for drug design

Umar Ndagi et al.

RSC ADVANCES (2020)

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Article Materials Science, Biomaterials

Hybrid silver-gold nanoparticles suppress drug resistant polymicrobial biofilm formation and intracellular infection

Eshant Bhatia et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Nanoscience & Nanotechnology

Leveraging metal oxide nanoparticles for bacteria tracing and eradicating

En Ren et al.

VIEW (2020)

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Article Chemistry, Applied

Mucoadhesive guargum hydrogel inter-connected chitosan-g-polycaprolactone micelles for rifampicin delivery

Xiaozhi Yuan et al.

CARBOHYDRATE POLYMERS (2019)

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Article Nanoscience & Nanotechnology

Antibacterial activity and mechanism of silver nanoparticles against multidrug-resistant Pseudomonas aeruginosa

Shijing Lia et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Infectious Diseases

Silver nanoparticles present high intracellular and extracellular killing against Staphylococcus aureus

Jason Kang et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2019)

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Article Biotechnology & Applied Microbiology

Effects of iron oxide (Fe3O4) nanoparticles on Escherichia coli antibiotic-resistant strains

L. Gabrielyan et al.

JOURNAL OF APPLIED MICROBIOLOGY (2019)

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Article Engineering, Environmental

Biosurfactant coated silver and iron oxide nanoparticles with enhanced anti-biofilm and anti-adhesive properties

Hafiza Faiza Khalid et al.

JOURNAL OF HAZARDOUS MATERIALS (2019)

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Article Biotechnology & Applied Microbiology

Improved antibacterial function of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus

Jalal Ghaderkhani et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

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Article Microbiology

Photocatalytic Protein Damage by Silver Nanoparticles Circumvents Bacterial Stress Response and Multidrug Resistance

Tianyuan Shi et al.

MSPHERE (2019)

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Article Materials Science, Multidisciplinary

Preparation of silver nanoparticles as antibacterial agents through DNA damage

Walaa Saeed Abbas et al.

MATERIALS TECHNOLOGY (2019)

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Article Engineering, Biomedical

An Ag-loaded photoactive nano-metal organic framework as a promising biofilm treatment

Ana Arenas-Vivo et al.

ACTA BIOMATERIALIA (2019)

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Article Public, Environmental & Occupational Health

The drivers of antibiotic use and misuse: the development and investigation of a theory driven community measure

Mitchell K. Byrne et al.

BMC PUBLIC HEALTH (2019)

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Review Biochemistry & Molecular Biology

Overcoming Hurdles in Nanoparticle Clinical Translation: The Influence of Experimental Design and Surface Modification

Jacob W. Shreffler et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Medicine, Research & Experimental

pH-Responsive Lipid-Dendrimer Hybrid Nanoparticles: An Approach To Target and Eliminate Intracellular Pathogens

Ruma Maji et al.

MOLECULAR PHARMACEUTICS (2019)

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Article Multidisciplinary Sciences

Thermo-responsive triple-function nanotransporter for efficient chemo-photothermal therapy of multidrug-resistant bacterial infection

Guangchao Qing et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Endogenous stimulus-powered antibiotic release from nanoreactors for a combination therapy of bacterial infections

Yang Wu et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Antimicrobial activity of Titanium dioxide and Zinc oxide nanoparticles supported in 4A zeolite and evaluation the morphological characteristic

Maryam Azizi-Lalabadi et al.

SCIENTIFIC REPORTS (2019)

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Article Infectious Diseases

The Anti-Mycobacterial Activity Of Ag, ZnO, And Ag- ZnO Nanoparticles Against MDR- And XDR-Mycobacterium tuberculosis

Mohsen Heidary et al.

INFECTION AND DRUG RESISTANCE (2019)

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Article Infectious Diseases

Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

Alessandro Cassini et al.

LANCET INFECTIOUS DISEASES (2019)

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Article Chemistry, Medicinal

Kill the Real with the Fake: Eliminate Intracellular Staphylococcus aureus Using Nanoparticle Coated with Its Extracellular Vesicle Membrane as Active-Targeting Drug Carrier

Feng Gao et al.

ACS INFECTIOUS DISEASES (2019)

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Article Chemistry, Multidisciplinary

Rutile nano-bio-interactions mediate dissimilar intracellular destiny in human skin cells

P. L. Sanches et al.

NANOSCALE ADVANCES (2019)

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Article Infectious Diseases

Rifampicin-Loaded Mesoporous Silica Nanoparticles for the Treatment of Intracellular Infections

Santhni Subramaniam et al.

ANTIBIOTICS-BASEL (2019)

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Article Biochemistry & Molecular Biology

Antibacterial mechanism of gold nanoparticles on Streptococcus pneumoniae

Edgar Augusto Ortiz-Benitez et al.

METALLOMICS (2019)

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Article Chemistry, Multidisciplinary

pH-Responsive, Light-Triggered on-Demand Antibiotic Release from Functional Metal-Organic Framework for Bacterial Infection Combination Therapy

Zhiyong Song et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Gold Nanoclusters for Targeting Methicillin-Resistant Staphylococcusaureus InVivo

Yangzhouyun Xie et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Article Immunology

Antimicrobial activity of nanoemulsion on drug-resistant bacterial pathogens

Rajapandiyan Krishnamoorthy et al.

MICROBIAL PATHOGENESIS (2018)

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Article Engineering, Biomedical

Antibacterial Activity of Silver Nanoparticles: Structural Effects

Shaoheng Tang et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Gold Coating of Silver Nanoplates for Enhanced Dispersion Stability and Efficient Antimicrobial Activity against Intracellular Bacteria

Hiroaki Ichimaru et al.

LANGMUIR (2018)

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Article Chemistry, Multidisciplinary

MoS2@polydopamine-Ag nanosheets with enhanced antibacterial activity for effective treatment of Staphylococcus aureus biofilms and wound infection

Lihui Yuwen et al.

NANOSCALE (2018)

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Article Chemistry, Multidisciplinary

Pretreated Macrophage-Membrane-Coated Gold Nanocages for Precise Drug Delivery for Treatment of Bacterial Infections

Can Wang et al.

ADVANCED MATERIALS (2018)

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Article Chemistry, Physical

Physico-chemistry from initial bacterial adhesion to surface-programmed biofilm growth

Vera Carniello et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2018)

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Article Nanoscience & Nanotechnology

Insights into the antibacterial mechanism of PEGylated nano-bacitracin A against Streptococcus pneumonia: both penicillin-sensitive and penicillin-resistant strains

Wei Hong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Oncology

Antimicrobial photodynamic activity of rose bengal conjugated multi walled carbon nanotubes against planktonic cells and biofilm of Escherichia coli

V. T. Anju et al.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2018)

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Article Chemistry, Multidisciplinary

Cross-Linked Polymer-Stabilized Nanocomposites for the Treatment of Bacteria Biofilms

Ryan F. Landis et al.

ACS NANO (2017)

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Article Chemistry, Multidisciplinary

Multivalent gold nanoparticle-peptide conjugates for targeting intracellular bacterial infections

Rimi Chowdhury et al.

NANOSCALE (2017)

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Article Multidisciplinary Sciences

Platinum nanoparticles induce damage to DNA and inhibit DNA replication

Lukas Nejdl et al.

PLOS ONE (2017)

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Article Biophysics

Trimethyl chitosan-capped silver nanoparticles with positive surface charge: Their catalytic activity and antibacterial spectrum including multidrug-resistant strains of Acinetobacter baumannii

T. Y. Chang et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

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Review Chemistry, Multidisciplinary

Chemical Strategies To Target Bacterial Virulence

Megan Garland et al.

CHEMICAL REVIEWS (2017)

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Article Nanoscience & Nanotechnology

Nanoparticle-Mediated Photodynamic Therapy for Mixed Biofilms

Marina Usacheva et al.

JOURNAL OF NANOMATERIALS (2016)

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Article Biotechnology & Applied Microbiology

Antimicrobial potentials of Helicteres isora silver nanoparticles against extensively drug-resistant (XDR) clinical isolates of Pseudomonas aeruginosa

Nikunj Mapara et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Poly(Propylene Imine) Dendrimers and Amoxicillin as Dual-Action Antibacterial Agents

Natalia Wronska et al.

MOLECULES (2015)

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Article Nanoscience & Nanotechnology

An environmentally benign antimicrobial nanoparticle based on a silver-infused lignin core

Alexander P. Richter et al.

NATURE NANOTECHNOLOGY (2015)

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Article Multidisciplinary Sciences

Alteration of intracellular protein expressions as a key mechanism of the deterioration of bacterial denitrification caused by copper oxide nanoparticles

Yinglong Su et al.

SCIENTIFIC REPORTS (2015)

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Review Chemistry, Multidisciplinary

Biodegradable nanoparticles for intracellular delivery of antimicrobial agents

Shuyu Xie et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Article Biochemistry & Molecular Biology

Controllable synthesis of ZnO nanoparticles and their morphology-dependent antibacterial and optical properties

Nasrin Talebian et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2013)

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Article Biochemical Research Methods

Composite nanoparticles: the best of two worlds

Colleen M. Janczak et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2012)

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Article Chemistry, Multidisciplinary

Superparamagnetic Iron Oxide Nanoparticles (SPION) for the Treatment of Antibiotic-Resistant Biofilms

Erik N. Taylor et al.

SMALL (2012)

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Article Chemistry, Multidisciplinary

Bacterial Toxin-Triggered Drug Release from Gold Nanoparticle-Stabilized Liposomes for the Treatment of Bacterial Infection

Dissaya Pornpattananangkul et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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